Anatomical and molecular reinvestigation of lamprey endostyle development provides new insight into thyroid gland evolution
The thyroid gland of vertebrates is considered to be homologous to the endostyle of non-vertebrate chordates (cephalochordates, urochordates), a key character for understanding the origin and evolution of the chordate body plan. In lampreys, the larval endostyle transforms into an adult thyroid glan...
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| Veröffentlicht in: | Development genes and evolution 2005-01, Vol.215 (1), p.32-40 |
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| creator | Kluge, Bernhard Renault, Nathalie Rohr, Klaus B |
| description | The thyroid gland of vertebrates is considered to be homologous to the endostyle of non-vertebrate chordates (cephalochordates, urochordates), a key character for understanding the origin and evolution of the chordate body plan. In lampreys, the larval endostyle transforms into an adult thyroid gland during metamorphosis, reflecting evolutionary changes that occurred in the vertebrate lineage. Focussing on thyroid-like cells in the endostyle, we here relate morphologically visible steps of lamprey (Lampetra fluviatilis) endostyle differentiation to embryonic stages and determine the onset of thyroid-like function. Analysing lamprey endostyle development using semi-thin histological sections, immunohistochemical detection of thyroid hormone, and the molecular marker thyroid transcription factor1 (Ttf1) refines our current view of the homology between endostyle and thyroid gland. In contrast to earlier literature, we find that a duct always persists to connect the endostyle lumen to the pharynx, a structure that resembles the thyroglossal duct in thyroid development and could further support the homology between endostyle and thyroid. Before the onset of thyroid-like function, Ttf1 expression becomes restricted to the ventral part of the endostyle, on the one hand showing that dorsal thyroid-like cells produce thyroid hormone in the absence of Ttf1, and on the other suggesting that Ttf1 was initially involved in specifying ventral fates in the endostyle. |
| doi_str_mv | 10.1007/s00427-004-0450-0 |
| format | Article |
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In lampreys, the larval endostyle transforms into an adult thyroid gland during metamorphosis, reflecting evolutionary changes that occurred in the vertebrate lineage. Focussing on thyroid-like cells in the endostyle, we here relate morphologically visible steps of lamprey (Lampetra fluviatilis) endostyle differentiation to embryonic stages and determine the onset of thyroid-like function. Analysing lamprey endostyle development using semi-thin histological sections, immunohistochemical detection of thyroid hormone, and the molecular marker thyroid transcription factor1 (Ttf1) refines our current view of the homology between endostyle and thyroid gland. In contrast to earlier literature, we find that a duct always persists to connect the endostyle lumen to the pharynx, a structure that resembles the thyroglossal duct in thyroid development and could further support the homology between endostyle and thyroid. Before the onset of thyroid-like function, Ttf1 expression becomes restricted to the ventral part of the endostyle, on the one hand showing that dorsal thyroid-like cells produce thyroid hormone in the absence of Ttf1, and on the other suggesting that Ttf1 was initially involved in specifying ventral fates in the endostyle.</description><identifier>ISSN: 0949-944X</identifier><identifier>EISSN: 1432-041X</identifier><identifier>DOI: 10.1007/s00427-004-0450-0</identifier><identifier>PMID: 15592682</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological Evolution ; Cell Differentiation ; Embryo, Nonmammalian ; Female ; Gene Expression Regulation, Developmental ; Homeodomain Proteins - chemistry ; Homeodomain Proteins - genetics ; Immunohistochemistry ; In Situ Hybridization ; Lampreys - anatomy & histology ; Larva ; Male ; Metamorphosis, Biological ; Models, Biological ; Molecular Biology ; Molecular Sequence Data ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Thyroid Gland - cytology ; Thyroid Gland - embryology ; Thyroid Gland - metabolism ; Thyroxine - biosynthesis ; Time Factors ; Transcription Factors - chemistry ; Transcription Factors - genetics</subject><ispartof>Development genes and evolution, 2005-01, Vol.215 (1), p.32-40</ispartof><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-fe332b68ee7c4b026d866201e6792a25cb44d197fe968db81e9fdc2aa418a7a33</citedby><cites>FETCH-LOGICAL-c326t-fe332b68ee7c4b026d866201e6792a25cb44d197fe968db81e9fdc2aa418a7a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15592682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kluge, Bernhard</creatorcontrib><creatorcontrib>Renault, Nathalie</creatorcontrib><creatorcontrib>Rohr, Klaus B</creatorcontrib><title>Anatomical and molecular reinvestigation of lamprey endostyle development provides new insight into thyroid gland evolution</title><title>Development genes and evolution</title><addtitle>Dev Genes Evol</addtitle><description>The thyroid gland of vertebrates is considered to be homologous to the endostyle of non-vertebrate chordates (cephalochordates, urochordates), a key character for understanding the origin and evolution of the chordate body plan. 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Before the onset of thyroid-like function, Ttf1 expression becomes restricted to the ventral part of the endostyle, on the one hand showing that dorsal thyroid-like cells produce thyroid hormone in the absence of Ttf1, and on the other suggesting that Ttf1 was initially involved in specifying ventral fates in the endostyle.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological Evolution</subject><subject>Cell Differentiation</subject><subject>Embryo, Nonmammalian</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Homeodomain Proteins - chemistry</subject><subject>Homeodomain Proteins - genetics</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Lampreys - anatomy & histology</subject><subject>Larva</subject><subject>Male</subject><subject>Metamorphosis, Biological</subject><subject>Models, Biological</subject><subject>Molecular Biology</subject><subject>Molecular Sequence Data</subject><subject>RNA, Messenger - 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Before the onset of thyroid-like function, Ttf1 expression becomes restricted to the ventral part of the endostyle, on the one hand showing that dorsal thyroid-like cells produce thyroid hormone in the absence of Ttf1, and on the other suggesting that Ttf1 was initially involved in specifying ventral fates in the endostyle.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15592682</pmid><doi>10.1007/s00427-004-0450-0</doi><tpages>9</tpages></addata></record> |
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| ispartof | Development genes and evolution, 2005-01, Vol.215 (1), p.32-40 |
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| subjects | Amino Acid Sequence Animals Base Sequence Biological Evolution Cell Differentiation Embryo, Nonmammalian Female Gene Expression Regulation, Developmental Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Immunohistochemistry In Situ Hybridization Lampreys - anatomy & histology Larva Male Metamorphosis, Biological Models, Biological Molecular Biology Molecular Sequence Data RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Thyroid Gland - cytology Thyroid Gland - embryology Thyroid Gland - metabolism Thyroxine - biosynthesis Time Factors Transcription Factors - chemistry Transcription Factors - genetics |
| title | Anatomical and molecular reinvestigation of lamprey endostyle development provides new insight into thyroid gland evolution |
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