Small-Molecule-Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity

The fine control of enzyme activity is essential for the regulation of many important cellular and organismal functions. The light-regulation of proteins serves as an important method for the spatiotemporal control over the production and degradation of an enzyme product. This area is of intense int...

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Veröffentlicht in:	Journal of the American Chemical Society 2016-01, Vol.138 (3), p.955-961
Hauptverfasser:	Tian, Tian, Song, Yanyan, Wang, Jiaqi, Fu, Boshi, He, Zhiyong, Xu, Xianqun, Li, Anling, Zhou, Xin, Wang, Shaoru, Zhou, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Azo Compounds - chemistry Azo Compounds - metabolism Blood Coagulation - drug effects Circular Dichroism DNA - chemistry DNA - metabolism Dose-Response Relationship, Drug Enzyme Activation - drug effects Humans Light Molecular Structure Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure-Activity Relationship Telomere - chemistry Telomere - metabolism Thrombin - antagonists & inhibitors Thrombin - metabolism
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