Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Initiation and Promotion of GST-P-Positive Foci in Rat Liver: A Quantitative Analysis of Experimental Data Using a Stochastic Model

We use a stochastic model describing initiation and clonal growth of altered cells to analyze data from an initiation–promotion hepatocarcinogenesis experiment in female Wistar rats. Starting at 7 weeks of age, the animals were treated for 10 days with the initiating agent diethylnitrosamine (DEN, 1...

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Veröffentlicht in:	Toxicology and applied pharmacology 2000-08, Vol.167 (1), p.63-73
Hauptverfasser:	Luebeck, E.Georg, Buchmann, Albrecht, Stinchcombe, Stefan, Moolgavkar, Suresh H., Schwarz, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Female Glutathione Transferase - metabolism Liver - enzymology Liver Neoplasms, Experimental - chemically induced Medical sciences Polychlorinated Dibenzodioxins - toxicity Precancerous Conditions - chemically induced Rats Rats, Wistar Stochastic Processes Tumors
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