Safety of a thickened extensive casein hydrolysate formula
Abstract Objectives Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. Methods...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2016-02, Vol.32 (2), p.206-212 |
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| creator | Vandenplas, Yvan, M.D., Ph.D De Greef, Elisabeth, M.D Xinias, I., M.S Vrani, O., M.D Mavroudi, A., M.D Hammoud, M., M.D Al Refai, F., M.D Khalife, M.C., M.D Sayad, A., M.D Noun, P., M.D Farah, A., M.D Makhoul, G., M.D Orel, R., M.D., Ph.D Sokhn, M., M.D L'Homme, A., M.D Mohring, M.P., M.D Merhi, B. Abou, M.D Boulos, J., M.D El Masri, H., M.D Halut, C., M.D |
| description | Abstract Objectives Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. Methods Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF. Results A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study. Conclusions The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range. |
| doi_str_mv | 10.1016/j.nut.2015.08.008 |
| format | Article |
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Abou, M.D ; Boulos, J., M.D ; El Masri, H., M.D ; Halut, C., M.D</creator><creatorcontrib>Vandenplas, Yvan, M.D., Ph.D ; De Greef, Elisabeth, M.D ; Xinias, I., M.S ; Vrani, O., M.D ; Mavroudi, A., M.D ; Hammoud, M., M.D ; Al Refai, F., M.D ; Khalife, M.C., M.D ; Sayad, A., M.D ; Noun, P., M.D ; Farah, A., M.D ; Makhoul, G., M.D ; Orel, R., M.D., Ph.D ; Sokhn, M., M.D ; L'Homme, A., M.D ; Mohring, M.P., M.D ; Merhi, B. Abou, M.D ; Boulos, J., M.D ; El Masri, H., M.D ; Halut, C., M.D ; Allar Study Group</creatorcontrib><description>Abstract Objectives Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. Methods Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF. Results A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study. Conclusions The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2015.08.008</identifier><identifier>PMID: 26704966</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>(Extensive) hydrolysate ; Allergies ; Animals ; Antiregurgitation formula ; Babies ; Baby foods ; Body Height ; Body Weight ; Casein ; Caseins - administration & dosage ; Cattle ; Child Development ; Children ; Cow's milk ; Cow's milk allergy ; Dietary Carbohydrates - analysis ; Dietary Fats - analysis ; Dietary Fiber - analysis ; Dietary Proteins - analysis ; Double-Blind Method ; Energy Intake ; Female ; Food allergies ; Gastroenterology and Hepatology ; Humans ; Immunoglobulin E ; Immunoglobulin E - blood ; Infant ; Infant Formula - administration & dosage ; Infant nutrition ; Infants ; Laryngopharyngeal Reflux - prevention & control ; Male ; Milk ; Milk Hypersensitivity - prevention & control ; Pediatrics ; Prospective Studies ; Protein Hydrolysates - administration & dosage ; Proteins ; Safety ; Skin tests ; Thickened formula ; Viscosity ; Vomiting</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2016-02, Vol.32 (2), p.206-212</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 1, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-f7b2377154050d5cd7d6b363d53474830836915b9e4eb64dc3411ca3182b6513</citedby><cites>FETCH-LOGICAL-c506t-f7b2377154050d5cd7d6b363d53474830836915b9e4eb64dc3411ca3182b6513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0899900715003433$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26704966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vandenplas, Yvan, M.D., Ph.D</creatorcontrib><creatorcontrib>De Greef, Elisabeth, M.D</creatorcontrib><creatorcontrib>Xinias, I., M.S</creatorcontrib><creatorcontrib>Vrani, O., M.D</creatorcontrib><creatorcontrib>Mavroudi, A., M.D</creatorcontrib><creatorcontrib>Hammoud, M., M.D</creatorcontrib><creatorcontrib>Al Refai, F., M.D</creatorcontrib><creatorcontrib>Khalife, M.C., M.D</creatorcontrib><creatorcontrib>Sayad, A., M.D</creatorcontrib><creatorcontrib>Noun, P., M.D</creatorcontrib><creatorcontrib>Farah, A., M.D</creatorcontrib><creatorcontrib>Makhoul, G., M.D</creatorcontrib><creatorcontrib>Orel, R., M.D., Ph.D</creatorcontrib><creatorcontrib>Sokhn, M., M.D</creatorcontrib><creatorcontrib>L'Homme, A., M.D</creatorcontrib><creatorcontrib>Mohring, M.P., M.D</creatorcontrib><creatorcontrib>Merhi, B. Abou, M.D</creatorcontrib><creatorcontrib>Boulos, J., M.D</creatorcontrib><creatorcontrib>El Masri, H., M.D</creatorcontrib><creatorcontrib>Halut, C., M.D</creatorcontrib><creatorcontrib>Allar Study Group</creatorcontrib><title>Safety of a thickened extensive casein hydrolysate formula</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objectives Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. Methods Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF. Results A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study. Conclusions The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.</description><subject>(Extensive) hydrolysate</subject><subject>Allergies</subject><subject>Animals</subject><subject>Antiregurgitation formula</subject><subject>Babies</subject><subject>Baby foods</subject><subject>Body Height</subject><subject>Body Weight</subject><subject>Casein</subject><subject>Caseins - administration & dosage</subject><subject>Cattle</subject><subject>Child Development</subject><subject>Children</subject><subject>Cow's milk</subject><subject>Cow's milk allergy</subject><subject>Dietary Carbohydrates - analysis</subject><subject>Dietary Fats - analysis</subject><subject>Dietary Fiber - analysis</subject><subject>Dietary Proteins - analysis</subject><subject>Double-Blind Method</subject><subject>Energy Intake</subject><subject>Female</subject><subject>Food allergies</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Infant</subject><subject>Infant Formula - administration & dosage</subject><subject>Infant nutrition</subject><subject>Infants</subject><subject>Laryngopharyngeal Reflux - prevention & control</subject><subject>Male</subject><subject>Milk</subject><subject>Milk Hypersensitivity - prevention & control</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Protein Hydrolysates - administration & dosage</subject><subject>Proteins</subject><subject>Safety</subject><subject>Skin tests</subject><subject>Thickened formula</subject><subject>Viscosity</subject><subject>Vomiting</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1r3DAQhkVpaTYfP6CXYuilFzsz1pfVQqCEtA0EekjuQpbGRBuvnUp2qP99vWzaQg49zeV5X2aeYewdQoWA6nxbDfNU1YCygqYCaF6xDTaal1gL8ZptoDGmNAD6iB3nvAUANMq8ZUe10iCMUhv26dZ1NC3F2BWumO6jf6CBQkG_JhpyfKLCu0xxKO6XkMZ-yW6iohvTbu7dKXvTuT7T2fM8YXdfr-4uv5c3P75dX365Kb0ENZWdbmuuNUoBEoL0QQfVcsWD5EKLhkPDlUHZGhLUKhE8F4jecWzqVknkJ-zjofYxjT9nypPdxeyp791A45wtagWG1xLkin54gW7HOQ3rcislDXCUElYKD5RPY86JOvuY4s6lxSLYvVe7tatXu_dqobGr1zXz_rl5bncU_ib-iFyBzweAVhNPkZLNPtLgKcREfrJhjP-tv3iR9n0conf9Ay2U_11hc23B3u4fu_8rSgAuOOe_AcJLmsM</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Vandenplas, Yvan, M.D., Ph.D</creator><creator>De Greef, Elisabeth, M.D</creator><creator>Xinias, I., M.S</creator><creator>Vrani, O., M.D</creator><creator>Mavroudi, A., M.D</creator><creator>Hammoud, M., M.D</creator><creator>Al Refai, F., M.D</creator><creator>Khalife, M.C., M.D</creator><creator>Sayad, A., M.D</creator><creator>Noun, P., M.D</creator><creator>Farah, A., M.D</creator><creator>Makhoul, G., M.D</creator><creator>Orel, R., M.D., Ph.D</creator><creator>Sokhn, M., M.D</creator><creator>L'Homme, A., M.D</creator><creator>Mohring, M.P., M.D</creator><creator>Merhi, B. 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Abou, M.D ; Boulos, J., M.D ; El Masri, H., M.D ; Halut, C., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-f7b2377154050d5cd7d6b363d53474830836915b9e4eb64dc3411ca3182b6513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>(Extensive) hydrolysate</topic><topic>Allergies</topic><topic>Animals</topic><topic>Antiregurgitation formula</topic><topic>Babies</topic><topic>Baby foods</topic><topic>Body Height</topic><topic>Body Weight</topic><topic>Casein</topic><topic>Caseins - administration & dosage</topic><topic>Cattle</topic><topic>Child Development</topic><topic>Children</topic><topic>Cow's milk</topic><topic>Cow's milk allergy</topic><topic>Dietary Carbohydrates - analysis</topic><topic>Dietary Fats - analysis</topic><topic>Dietary Fiber - analysis</topic><topic>Dietary Proteins - analysis</topic><topic>Double-Blind Method</topic><topic>Energy Intake</topic><topic>Female</topic><topic>Food allergies</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Infant</topic><topic>Infant Formula - administration & dosage</topic><topic>Infant nutrition</topic><topic>Infants</topic><topic>Laryngopharyngeal Reflux - prevention & control</topic><topic>Male</topic><topic>Milk</topic><topic>Milk Hypersensitivity - prevention & control</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Protein Hydrolysates - administration & dosage</topic><topic>Proteins</topic><topic>Safety</topic><topic>Skin tests</topic><topic>Thickened formula</topic><topic>Viscosity</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vandenplas, Yvan, M.D., Ph.D</creatorcontrib><creatorcontrib>De Greef, Elisabeth, M.D</creatorcontrib><creatorcontrib>Xinias, I., M.S</creatorcontrib><creatorcontrib>Vrani, O., M.D</creatorcontrib><creatorcontrib>Mavroudi, A., M.D</creatorcontrib><creatorcontrib>Hammoud, M., M.D</creatorcontrib><creatorcontrib>Al Refai, F., M.D</creatorcontrib><creatorcontrib>Khalife, M.C., M.D</creatorcontrib><creatorcontrib>Sayad, A., M.D</creatorcontrib><creatorcontrib>Noun, P., M.D</creatorcontrib><creatorcontrib>Farah, A., M.D</creatorcontrib><creatorcontrib>Makhoul, G., M.D</creatorcontrib><creatorcontrib>Orel, R., M.D., Ph.D</creatorcontrib><creatorcontrib>Sokhn, M., M.D</creatorcontrib><creatorcontrib>L'Homme, A., M.D</creatorcontrib><creatorcontrib>Mohring, M.P., M.D</creatorcontrib><creatorcontrib>Merhi, B. Abou, M.D</creatorcontrib><creatorcontrib>Boulos, J., M.D</creatorcontrib><creatorcontrib>El Masri, H., M.D</creatorcontrib><creatorcontrib>Halut, C., M.D</creatorcontrib><creatorcontrib>Allar Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vandenplas, Yvan, M.D., Ph.D</au><au>De Greef, Elisabeth, M.D</au><au>Xinias, I., M.S</au><au>Vrani, O., M.D</au><au>Mavroudi, A., M.D</au><au>Hammoud, M., M.D</au><au>Al Refai, F., M.D</au><au>Khalife, M.C., M.D</au><au>Sayad, A., M.D</au><au>Noun, P., M.D</au><au>Farah, A., M.D</au><au>Makhoul, G., M.D</au><au>Orel, R., M.D., Ph.D</au><au>Sokhn, M., M.D</au><au>L'Homme, A., M.D</au><au>Mohring, M.P., M.D</au><au>Merhi, B. Abou, M.D</au><au>Boulos, J., M.D</au><au>El Masri, H., M.D</au><au>Halut, C., M.D</au><aucorp>Allar Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety of a thickened extensive casein hydrolysate formula</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>32</volume><issue>2</issue><spage>206</spage><epage>212</epage><pages>206-212</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>Abstract Objectives Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. Methods Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF. Results A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study. Conclusions The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26704966</pmid><doi>10.1016/j.nut.2015.08.008</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2016-02, Vol.32 (2), p.206-212 |
| issn | 0899-9007 1873-1244 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1760932505 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | (Extensive) hydrolysate Allergies Animals Antiregurgitation formula Babies Baby foods Body Height Body Weight Casein Caseins - administration & dosage Cattle Child Development Children Cow's milk Cow's milk allergy Dietary Carbohydrates - analysis Dietary Fats - analysis Dietary Fiber - analysis Dietary Proteins - analysis Double-Blind Method Energy Intake Female Food allergies Gastroenterology and Hepatology Humans Immunoglobulin E Immunoglobulin E - blood Infant Infant Formula - administration & dosage Infant nutrition Infants Laryngopharyngeal Reflux - prevention & control Male Milk Milk Hypersensitivity - prevention & control Pediatrics Prospective Studies Protein Hydrolysates - administration & dosage Proteins Safety Skin tests Thickened formula Viscosity Vomiting |
| title | Safety of a thickened extensive casein hydrolysate formula |
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