Propionic Acid Produced by Propionibacterium acnes Strains Contri-butes to Their Pathogenicity
Propionibacterium acnes is an important member of the skin microbiome. The bacterium can initiate signalling events and changes in cellular properties in keratinocytes. The aim of this study was to analyse the effect of the bacterium on an immortalized human keratinocyte cell line. The results show...
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| Veröffentlicht in: | Acta dermato-venereologica 2016-01, Vol.96 (1), p.43-49 |
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| container_title | Acta dermato-venereologica |
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| creator | Tax, Gábor Urbán, Edit Palotás, Zsuzsanna Puskás, Róbert Kónya, Zoltán Bíró, Tamás Kemény, Lajos Szabó, Kornélia |
| description | Propionibacterium acnes is an important member of the skin microbiome. The bacterium can initiate signalling events and changes in cellular properties in keratinocytes. The aim of this study was to analyse the effect of the bacterium on an immortalized human keratinocyte cell line. The results show that various P. acnes strains affect the cell-growth properties of these cells differentially, inducing cytotoxicity in a strain-specific and dose-dependent manner. We propose that bacterially secreted propionic acid may contribute to the cytotoxic effect. This acid has a role in maintaining skin pH and exhibits antimicrobial properties, but may also have deleterious effects when the local concentration rises due to excessive bacterial growth and metabolism. These results, together with available data from the literature, may provide insight into the dual role of P. acnes in healthy skin and during pathogenic conditions, as well as the key molecules involved in these functions. |
| doi_str_mv | 10.2340/00015555-2154 |
| format | Article |
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These results, together with available data from the literature, may provide insight into the dual role of P. acnes in healthy skin and during pathogenic conditions, as well as the key molecules involved in these functions.</description><subject>Bacterial Load</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Keratinocytes - metabolism</subject><subject>Keratinocytes - microbiology</subject><subject>Keratinocytes - pathology</subject><subject>Propionates - metabolism</subject><subject>Propionibacterium acnes - classification</subject><subject>Propionibacterium acnes - growth & development</subject><subject>Propionibacterium acnes - metabolism</subject><subject>Propionibacterium acnes - pathogenicity</subject><subject>Time Factors</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1PwzAQxS0EoqUwsiKPLAbbSexkrCq-pEpUoqxEjn2hRk1cbGfof4-jttxyevd-94aH0C2jDzzL6SOllBVpCGdFfoamTBSMcFrIczQdPTKaE3QVwk-SvGDlJZpwQbMqk2yKvlbe7azrrcZzbQ1O0gwaDG72-GQ1Skfwduiw0j0E_BG9sn3AC9dHb0kzxHSMDq83YD1eqbhx35ASbdxfo4tWbQPcHPcMfT4_rRevZPn-8raYL4lmUuZE8krLkuVNVUCrBEhhZMHzvKVGF0pwEE0FxgjGWlWC4E3eCKMULbVR6QuyGbo_5O68-x0gxLqzQcN2q3pwQ6iZFLTKmBAsoeSAau9C8NDWO2875fc1o_VYaX2qtB4rTfzdMXpoOjD_9KnD7A9zZXHO</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Tax, Gábor</creator><creator>Urbán, Edit</creator><creator>Palotás, Zsuzsanna</creator><creator>Puskás, Róbert</creator><creator>Kónya, Zoltán</creator><creator>Bíró, Tamás</creator><creator>Kemény, Lajos</creator><creator>Szabó, Kornélia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Propionic Acid Produced by Propionibacterium acnes Strains Contri-butes to Their Pathogenicity</title><author>Tax, Gábor ; Urbán, Edit ; Palotás, Zsuzsanna ; Puskás, Róbert ; Kónya, Zoltán ; Bíró, Tamás ; Kemény, Lajos ; Szabó, Kornélia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1774-729c7814b95efa6e76d75244f0dc5a62e6b9edd611fa8e62b4b6daa08cda14be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Bacterial Load</topic><topic>Cell Line</topic><topic>Cell Proliferation</topic><topic>Host-Pathogen Interactions</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Keratinocytes - metabolism</topic><topic>Keratinocytes - microbiology</topic><topic>Keratinocytes - pathology</topic><topic>Propionates - metabolism</topic><topic>Propionibacterium acnes - classification</topic><topic>Propionibacterium acnes - growth & development</topic><topic>Propionibacterium acnes - metabolism</topic><topic>Propionibacterium acnes - pathogenicity</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tax, Gábor</creatorcontrib><creatorcontrib>Urbán, Edit</creatorcontrib><creatorcontrib>Palotás, Zsuzsanna</creatorcontrib><creatorcontrib>Puskás, Róbert</creatorcontrib><creatorcontrib>Kónya, Zoltán</creatorcontrib><creatorcontrib>Bíró, Tamás</creatorcontrib><creatorcontrib>Kemény, Lajos</creatorcontrib><creatorcontrib>Szabó, Kornélia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tax, Gábor</au><au>Urbán, Edit</au><au>Palotás, Zsuzsanna</au><au>Puskás, Róbert</au><au>Kónya, Zoltán</au><au>Bíró, Tamás</au><au>Kemény, Lajos</au><au>Szabó, Kornélia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Propionic Acid Produced by Propionibacterium acnes Strains Contri-butes to Their Pathogenicity</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2016-01</date><risdate>2016</risdate><volume>96</volume><issue>1</issue><spage>43</spage><epage>49</epage><pages>43-49</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><abstract>Propionibacterium acnes is an important member of the skin microbiome. 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| subjects | Bacterial Load Cell Line Cell Proliferation Host-Pathogen Interactions Humans Hydrogen-Ion Concentration Keratinocytes - metabolism Keratinocytes - microbiology Keratinocytes - pathology Propionates - metabolism Propionibacterium acnes - classification Propionibacterium acnes - growth & development Propionibacterium acnes - metabolism Propionibacterium acnes - pathogenicity Time Factors |
| title | Propionic Acid Produced by Propionibacterium acnes Strains Contri-butes to Their Pathogenicity |
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