Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study

Summary Objective To investigate the efficacy of bevacizumab and trastuzumab combined with docetaxel, oxaliplatin, and capecitabine (B-DOCT) as first-line treatment of advanced human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC). Methods In this multicentre, single-arm, phas...

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Veröffentlicht in:	Investigational new drugs 2016-02, Vol.34 (1), p.119-128
Hauptverfasser:	Meulendijks, Didier, Beerepoot, Laurens V., Boot, Henk, de Groot, Jan Willem B., Los, Maartje, Boers, James E., Vanhoutvin, Steven A. L. W., Polee, Marco B., Beeker, Aart, Portielje, Johanna E. A., de Jong, Robert S., Goey, Swan H., Kuiper, Maria, Sikorska, Karolina, Beijnen, Jos H., Tesselaar, Margot E., Schellens, Jan H. M., Cats, Annemieke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Adult Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab - administration & dosage Cancer therapies Capecitabine - administration & dosage Chemotherapy Clinical trials Disease-Free Survival Epidermal growth factor Esophagogastric Junction - pathology Female Gastric cancer Hospitals Humans Immunohistochemistry Internal medicine Investigations Male Medical prognosis Medicine Medicine & Public Health Metastasis Middle Aged Monoclonal antibodies Neutropenia Oncology Organoplatinum Compounds - administration & dosage Pathology Patients Pharmaceuticals Pharmacology Pharmacology/Toxicology Phase II Studies Prescription drugs R&D Receptor, ErbB-2 - genetics Research & development Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Studies Taxoids - administration & dosage Trastuzumab - administration & dosage Tumors Vascular endothelial growth factor
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