Extracellular 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-ζ chain down-regulation via caspase-3 activation in oral cancer

Decreased expression of CD3-ζ chain, an adaptor protein associated with T-cell signalling, is well documented in patients with oral cancer, but the mechanistic justifications are fragmentary. Previous studies in patients with oral cancer have shown that decreased expression of CD3-ζ chain was associ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology 2016-02, Vol.147 (2), p.251-264
Hauptverfasser:	Dar, Asif A, Pradhan, Trupti N, Kulkarni, Dakshayni P, Shah, Sagar U, Rao, Kanury V, Chaukar, Devendra A, D'Cruz, Anil K, Chiplunkar, Shubhada V
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - genetics 2',5'-Oligoadenylate Synthetase - metabolism Case-Control Studies Caspase 3 - genetics Caspase 3 - metabolism CD3 Complex - immunology CD3 Complex - metabolism Cell Line, Tumor Down-Regulation Enzyme Activation Gene Expression Regulation, Neoplastic HEK293 Cells Humans Lymphocytes, Tumor-Infiltrating - enzymology Lymphocytes, Tumor-Infiltrating - immunology Mouth Neoplasms - enzymology Mouth Neoplasms - genetics Mouth Neoplasms - immunology Mouth Neoplasms - pathology Paracrine Communication Proteomics - methods Recombinant Proteins - metabolism RNA Interference Signal Transduction T-Lymphocytes - enzymology T-Lymphocytes - immunology Time Factors Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!