Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation

Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can serve as the loci of drug-drug interactions (DDI). To support the evaluation of cynomolgus monkey as a surrogate model for studying human organ...

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Veröffentlicht in:	Drug metabolism and disposition 2016-02, Vol.44 (2), p.238-249
Hauptverfasser:	Shen, Hong, Liu, Tongtong, Jiang, Hao, Titsch, Craig, Taylor, Kristin, Kandoussi, Hamza, Qiu, Xi, Chen, Cliff, Sukrutharaj, Sunil, Kuit, Kathy, Mintier, Gabe, Krishnamurthy, Prasad, Fancher, R. Marcus, Zeng, Jianing, Rodrigues, A. David, Marathe, Punit, Lai, Yurong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cations - metabolism Cell Line Drug Interactions - physiology HEK293 Cells Humans Kidney - metabolism Kinetics Macaca fascicularis Metformin - metabolism Organic Cation Transport Proteins - metabolism Pyrimethamine - metabolism
Online-Zugang:	Volltext
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