Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

In contrast to mammals, zebrafish regenerate heart injuries via proliferation of cardiomyocytes located near the wound border. To identify regulators of cardiomyocyte proliferation, we used spatially resolved RNA sequencing (tomo-seq) and generated a high-resolution genome-wide atlas of gene express...

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Veröffentlicht in:	Developmental cell 2016-01, Vol.36 (1), p.36-49
Hauptverfasser:	Wu, Chi-Chung, Kruse, Fabian, Vasudevarao, Mohankrishna Dalvoy, Junker, Jan Philipp, Zebrowski, David C., Fischer, Kristin, Noël, Emily S., Grün, Dominic, Berezikov, Eugene, Engel, Felix B., van Oudenaarden, Alexander, Weidinger, Gilbert, Bakkers, Jeroen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell Differentiation Cell Proliferation - genetics Gene Expression Regulation - genetics Genome - genetics Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Regeneration - physiology Signal Transduction - genetics Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - metabolism
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