Clinical characteristics and pertussis costs in cases reported to epidemiological services and cases detected in household contacts in Catalonia (Spain)
Purpose To assess the clinical characteristics and direct health costs associated with pertussis cases reported to and confirmed by epidemiological services and cases detected among household contacts in Catalonia (Spain) in 2012–2013. Methods All pertussis cases confirmed by the epidemiological ser...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2016-02, Vol.35 (2), p.285-292 |
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| creator | Plans, P. Muñoz-Almagro, C. Godoy, P. Jané, M. Carmona, G. |
| description | Purpose
To assess the clinical characteristics and direct health costs associated with pertussis cases reported to and confirmed by epidemiological services and cases detected among household contacts in Catalonia (Spain) in 2012–2013.
Methods
All pertussis cases confirmed by the epidemiological services (
n
= 641) and all cases detected among the household contacts (
n
= 422) were included in the study. The chi-square test and odds ratios were used to compare percentages and the
t
-test was used to compare mean pertussis costs, with
p
|
| doi_str_mv | 10.1007/s10096-015-2542-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1760924001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3930919101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-b4c0c3fa9626395121bb9aebe588ac5331c86cb62240183f3b33485f944531153</originalsourceid><addsrcrecordid>eNp1kU1rFTEUhoMo9lr9AW4k4KZdjOZzZrKUi19QcKGuQyZzpjdlbjLmZAr9J_5ccztVRHCTLM7zPufAS8hLzt5wxrq3WF_TNozrRmglGvmI7LiSulGyk4_JjhmpGtMJeUaeId6wmum77ik5E23HeyPNjvzczyEG72bqDy47XyAHLMEjdXGkC-SyIgakPmFBGiL1DgFphiXlAiMticISRjiGNKfrexFCvg0eNsOGj1DAn_AqOKQV4ZDmOkux1I332r0rbk4xOHrxdXEhXj4nTyY3I7x4-M_J9w_vv-0_NVdfPn7ev7tqvFKiNIPyzMvJmVa00mgu-DAYBwPovndeS8l93_qhFUIx3stJDlKqXk9GKS051_KcXGzeJacfK2Cxx4Ae5tlFqJda3rXM1DDjFX39D3qT1hzrdZXSRghuTFcpvlE-J8QMk11yOLp8Zzmzp9rsVputtdlTbVbWzKsH8zocYfyT-N1TBcQGYB3Fa8h_rf6v9RfRTqPs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1759221997</pqid></control><display><type>article</type><title>Clinical characteristics and pertussis costs in cases reported to epidemiological services and cases detected in household contacts in Catalonia (Spain)</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><creator>Plans, P. ; Muñoz-Almagro, C. ; Godoy, P. ; Jané, M. ; Carmona, G.</creator><creatorcontrib>Plans, P. ; Muñoz-Almagro, C. ; Godoy, P. ; Jané, M. ; Carmona, G.</creatorcontrib><description>Purpose
To assess the clinical characteristics and direct health costs associated with pertussis cases reported to and confirmed by epidemiological services and cases detected among household contacts in Catalonia (Spain) in 2012–2013.
Methods
All pertussis cases confirmed by the epidemiological services (
n
= 641) and all cases detected among the household contacts (
n
= 422) were included in the study. The chi-square test and odds ratios were used to compare percentages and the
t
-test was used to compare mean pertussis costs, with
p
< 0.05 being considered statistically significant.
Results
Cases reported to epidemiological services had a higher percentage of hospitalizations (OR = 32.2,
p
< 0.001) and severe disease (OR = 27.7,
p
< 0.001) than cases detected among the household contacts. The total health costs associated with pertussis cases were €871,648, €799,704 (92 %) for cases reported to epidemiological services and €71,944 (8 %) for cases detected among the household contacts. Total treatment, detection, and quimiprophylaxis costs were € 809,702, € 44,312, and € 17,635, representing 92.5 %, 5.5 %, and 2 % of total pertussis costs respectively. The mean costs were significantly higher (
p
< 0.001) in cases reported to epidemiological services than in cases detected among the household contacts, for all cases (€1248 vs €170), and for severe (€4546 vs €1073), moderate (€204 vs €165), and mild (€153 vs €133) disease.
Conclusions
The burden of pertussis in Catalonia was high in terms of health costs, especially in infants aged less than 1 year. Active epidemiological surveillance activities could prevent pertussis transmisison and reduce pertussis costs.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-015-2542-3</identifier><identifier>PMID: 26718939</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Child ; Child, Preschool ; Cost of Illness ; Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage ; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology ; Epidemiological Monitoring ; Epidemiology ; Female ; Health Care Costs - statistics & numerical data ; Health surveillance ; Hospitalization - economics ; Hospitalization - statistics & numerical data ; Households ; Humans ; Illnesses ; Infant ; Internal Medicine ; Male ; Medical Microbiology ; Middle Aged ; Original Article ; Public health ; Spain - epidemiology ; Surveys and Questionnaires ; Vaccines ; Whooping cough ; Whooping Cough - diagnosis ; Whooping Cough - economics ; Whooping Cough - epidemiology ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2016-02, Vol.35 (2), p.285-292</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-b4c0c3fa9626395121bb9aebe588ac5331c86cb62240183f3b33485f944531153</citedby><cites>FETCH-LOGICAL-c442t-b4c0c3fa9626395121bb9aebe588ac5331c86cb62240183f3b33485f944531153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-015-2542-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-015-2542-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26718939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plans, P.</creatorcontrib><creatorcontrib>Muñoz-Almagro, C.</creatorcontrib><creatorcontrib>Godoy, P.</creatorcontrib><creatorcontrib>Jané, M.</creatorcontrib><creatorcontrib>Carmona, G.</creatorcontrib><title>Clinical characteristics and pertussis costs in cases reported to epidemiological services and cases detected in household contacts in Catalonia (Spain)</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Purpose
To assess the clinical characteristics and direct health costs associated with pertussis cases reported to and confirmed by epidemiological services and cases detected among household contacts in Catalonia (Spain) in 2012–2013.
Methods
All pertussis cases confirmed by the epidemiological services (
n
= 641) and all cases detected among the household contacts (
n
= 422) were included in the study. The chi-square test and odds ratios were used to compare percentages and the
t
-test was used to compare mean pertussis costs, with
p
< 0.05 being considered statistically significant.
Results
Cases reported to epidemiological services had a higher percentage of hospitalizations (OR = 32.2,
p
< 0.001) and severe disease (OR = 27.7,
p
< 0.001) than cases detected among the household contacts. The total health costs associated with pertussis cases were €871,648, €799,704 (92 %) for cases reported to epidemiological services and €71,944 (8 %) for cases detected among the household contacts. Total treatment, detection, and quimiprophylaxis costs were € 809,702, € 44,312, and € 17,635, representing 92.5 %, 5.5 %, and 2 % of total pertussis costs respectively. The mean costs were significantly higher (
p
< 0.001) in cases reported to epidemiological services than in cases detected among the household contacts, for all cases (€1248 vs €170), and for severe (€4546 vs €1073), moderate (€204 vs €165), and mild (€153 vs €133) disease.
Conclusions
The burden of pertussis in Catalonia was high in terms of health costs, especially in infants aged less than 1 year. Active epidemiological surveillance activities could prevent pertussis transmisison and reduce pertussis costs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cost of Illness</subject><subject>Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage</subject><subject>Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology</subject><subject>Epidemiological Monitoring</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health Care Costs - statistics & numerical data</subject><subject>Health surveillance</subject><subject>Hospitalization - economics</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Households</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Infant</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Public health</subject><subject>Spain - epidemiology</subject><subject>Surveys and Questionnaires</subject><subject>Vaccines</subject><subject>Whooping cough</subject><subject>Whooping Cough - diagnosis</subject><subject>Whooping Cough - economics</subject><subject>Whooping Cough - epidemiology</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1rFTEUhoMo9lr9AW4k4KZdjOZzZrKUi19QcKGuQyZzpjdlbjLmZAr9J_5ccztVRHCTLM7zPufAS8hLzt5wxrq3WF_TNozrRmglGvmI7LiSulGyk4_JjhmpGtMJeUaeId6wmum77ik5E23HeyPNjvzczyEG72bqDy47XyAHLMEjdXGkC-SyIgakPmFBGiL1DgFphiXlAiMticISRjiGNKfrexFCvg0eNsOGj1DAn_AqOKQV4ZDmOkux1I332r0rbk4xOHrxdXEhXj4nTyY3I7x4-M_J9w_vv-0_NVdfPn7ev7tqvFKiNIPyzMvJmVa00mgu-DAYBwPovndeS8l93_qhFUIx3stJDlKqXk9GKS051_KcXGzeJacfK2Cxx4Ae5tlFqJda3rXM1DDjFX39D3qT1hzrdZXSRghuTFcpvlE-J8QMk11yOLp8Zzmzp9rsVputtdlTbVbWzKsH8zocYfyT-N1TBcQGYB3Fa8h_rf6v9RfRTqPs</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Plans, P.</creator><creator>Muñoz-Almagro, C.</creator><creator>Godoy, P.</creator><creator>Jané, M.</creator><creator>Carmona, G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Clinical characteristics and pertussis costs in cases reported to epidemiological services and cases detected in household contacts in Catalonia (Spain)</title><author>Plans, P. ; Muñoz-Almagro, C. ; Godoy, P. ; Jané, M. ; Carmona, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-b4c0c3fa9626395121bb9aebe588ac5331c86cb62240183f3b33485f944531153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cost of Illness</topic><topic>Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage</topic><topic>Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology</topic><topic>Epidemiological Monitoring</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health Care Costs - statistics & numerical data</topic><topic>Health surveillance</topic><topic>Hospitalization - economics</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Households</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Infant</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Public health</topic><topic>Spain - epidemiology</topic><topic>Surveys and Questionnaires</topic><topic>Vaccines</topic><topic>Whooping cough</topic><topic>Whooping Cough - diagnosis</topic><topic>Whooping Cough - economics</topic><topic>Whooping Cough - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plans, P.</creatorcontrib><creatorcontrib>Muñoz-Almagro, C.</creatorcontrib><creatorcontrib>Godoy, P.</creatorcontrib><creatorcontrib>Jané, M.</creatorcontrib><creatorcontrib>Carmona, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plans, P.</au><au>Muñoz-Almagro, C.</au><au>Godoy, P.</au><au>Jané, M.</au><au>Carmona, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and pertussis costs in cases reported to epidemiological services and cases detected in household contacts in Catalonia (Spain)</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>35</volume><issue>2</issue><spage>285</spage><epage>292</epage><pages>285-292</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Purpose
To assess the clinical characteristics and direct health costs associated with pertussis cases reported to and confirmed by epidemiological services and cases detected among household contacts in Catalonia (Spain) in 2012–2013.
Methods
All pertussis cases confirmed by the epidemiological services (
n
= 641) and all cases detected among the household contacts (
n
= 422) were included in the study. The chi-square test and odds ratios were used to compare percentages and the
t
-test was used to compare mean pertussis costs, with
p
< 0.05 being considered statistically significant.
Results
Cases reported to epidemiological services had a higher percentage of hospitalizations (OR = 32.2,
p
< 0.001) and severe disease (OR = 27.7,
p
< 0.001) than cases detected among the household contacts. The total health costs associated with pertussis cases were €871,648, €799,704 (92 %) for cases reported to epidemiological services and €71,944 (8 %) for cases detected among the household contacts. Total treatment, detection, and quimiprophylaxis costs were € 809,702, € 44,312, and € 17,635, representing 92.5 %, 5.5 %, and 2 % of total pertussis costs respectively. The mean costs were significantly higher (
p
< 0.001) in cases reported to epidemiological services than in cases detected among the household contacts, for all cases (€1248 vs €170), and for severe (€4546 vs €1073), moderate (€204 vs €165), and mild (€153 vs €133) disease.
Conclusions
The burden of pertussis in Catalonia was high in terms of health costs, especially in infants aged less than 1 year. Active epidemiological surveillance activities could prevent pertussis transmisison and reduce pertussis costs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26718939</pmid><doi>10.1007/s10096-015-2542-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2016-02, Vol.35 (2), p.285-292 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1760924001 |
| source | MEDLINE; SpringerNature Complete Journals |
| subjects | Adolescent Adult Aged Biomedical and Life Sciences Biomedicine Child Child, Preschool Cost of Illness Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology Epidemiological Monitoring Epidemiology Female Health Care Costs - statistics & numerical data Health surveillance Hospitalization - economics Hospitalization - statistics & numerical data Households Humans Illnesses Infant Internal Medicine Male Medical Microbiology Middle Aged Original Article Public health Spain - epidemiology Surveys and Questionnaires Vaccines Whooping cough Whooping Cough - diagnosis Whooping Cough - economics Whooping Cough - epidemiology Young Adult |
| title | Clinical characteristics and pertussis costs in cases reported to epidemiological services and cases detected in household contacts in Catalonia (Spain) |
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