Molecular Dissection of the Homotrimeric Sliding Clamp of T4 Phage: Two Domains of a Subunit Display Asymmetric Characteristics

Sliding clamp proteins are circular dimers or trimers that encircle DNA and serve as processivity factors during DNA replication. Their presence in all the three domains of life and in bacteriophages clearly indicates their high level of significance. T4 gp45, besides functioning as the DNA polymera...

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Veröffentlicht in:	Biochemistry (Easton) 2016-01, Vol.55 (3), p.588-596
Hauptverfasser:	Singh, Manika Indrajit, Jain, Vikas
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophage T4 - metabolism Protein Denaturation Protein Multimerization Protein Structure, Tertiary Protein Subunits - chemistry Solutions Trans-Activators - chemistry Viral Proteins - chemistry
Online-Zugang:	Volltext
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