A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves Aβ25–35-impaired mouse cognitive function

Rationale The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD thera...

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Veröffentlicht in:	Psychopharmacology 2016-02, Vol.233 (4), p.599-613
Hauptverfasser:	Zhang, Zhengping, Chen, Rong, An, Wenji, Wang, Chunmei, Liao, Gaoyong, Dong, Xiaoliang, Bi, Aijing, Yin, Zhimin, Luo, Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - toxicity Animals Biomedical and Life Sciences Biomedicine Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Cell Line, Tumor CHO Cells Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Cognition - drug effects Cognition - physiology Cognition Disorders - chemically induced Cognition Disorders - drug therapy Cognition Disorders - metabolism Cricetinae Cricetulus Dose-Response Relationship, Drug HEK293 Cells Humans Male Maze Learning - drug effects Maze Learning - physiology Mice Mice, Inbred ICR Neurosciences Original Investigation Peptide Fragments - antagonists & inhibitors Peptide Fragments - toxicity Pharmacology/Toxicology Psychiatry Rats Rats, Wistar Tacrine - analogs & derivatives Tacrine - pharmacology Tacrine - therapeutic use
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