2-Acetyl-7-hydroxy-6-methoxy-1-methyl-1,2,3,4,-tetrahydroisoquinoline exhibits anti-inflammatory properties and protects the nigral dopaminergic neurons

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by degeneration of dopamine(DA)ergic neurons. Neuroinflammation caused by microglial activation is believed to be involved in the pathogenesis of neurodegenerative diseases including PD. In the present study, we tested the effect...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2016-01, Vol.771, p.152-161
Hauptverfasser:	Son, Hyo Jin, Han, Se Hee, Lee, Ji Ae, Lee, Cheol Soon, Seo, Jai Woong, Chi, Dae Yoon, Hwang, Onyou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacokinetics Anti-Inflammatory Agents - pharmacology Antiparkinson Agents - pharmacokinetics Antiparkinson Agents - pharmacology Blood-Brain Barrier - metabolism Brain - metabolism Cell Line Cytokines - biosynthesis Cytokines - genetics Dopaminergic Neurons - drug effects Humans In Vitro Techniques Isoquinolines - pharmacokinetics Isoquinolines - pharmacology Macrophage Activation - drug effects Male Mice Mice, Inbred C57BL Mice, Inbred ICR Microglia Microglia - drug effects Microsomes, Liver - drug effects Microsomes, Liver - enzymology Motor deficits Neuroinflammation Neuroprotective Agents - pharmacokinetics Neuroprotective Agents - pharmacology Nitric Oxide - metabolism Parkinson’s disease Substantia nigra Substantia Nigra - cytology Substantia Nigra - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!