Association of COPD exacerbation frequency with gene expression of pattern recognition receptors in inflammatory cells in induced sputum

Background Bacteria and viruses are major causes of chronic obstructive pulmonary disease (COPD) exacerbations. Molecular components of these pathogens are recognized by pattern‐recognition receptors (PRRs) expressed by various cells in the airway, which leads to initiation of inflammatory processes...

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Veröffentlicht in:	The clinical respiratory journal 2016-01, Vol.10 (1), p.11-21
Hauptverfasser:	Kinose, Daisuke, Ogawa, Emiko, Kudo, Megumi, Marumo, Satoshi, Kiyokawa, Hirofumi, Hoshino, Yuma, Hirai, Toyohiro, Chin, Kazuo, Muro, Shigeo, Mishima, Michiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Chronic obstructive pulmonary disease COPD exacerbation Gene expression Humans induced sputum Inflammation - metabolism innate immune system Male Neutrophils Prospective Studies Pulmonary Disease, Chronic Obstructive - immunology Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - microbiology Receptors, Pattern Recognition - genetics Receptors, Pattern Recognition - immunology Receptors, Pattern Recognition - metabolism Sputum - immunology Sputum - metabolism Sputum - microbiology TLR3 Toll-Like Receptor 3 - immunology Toll-Like Receptor 3 - metabolism
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