Up‐regulation of P2X7 receptor–mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex

Summary Objective Thirty percent of patients with epilepsy are refractory to medication. The majority of these patients have mesial temporal lobe epilepsy (MTLE). This prompts for new pharmacologic targets, like ATP‐mediated signaling pathways, since the extracellular levels of the nucleotide dramat...

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Veröffentlicht in:Epilepsia (Copenhagen) 2016-01, Vol.57 (1), p.99-110
Hauptverfasser: Barros‐Barbosa, Aurora R., Fonseca, Ana L., Guerra‐Gomes, Sónia, Ferreirinha, Fátima, Santos, Agostinho, Rangel, Rui, Lobo, M. Graça, Correia‐de‐Sá, Paulo, Cordeiro, J. Miguel
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Sprache:eng
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