Neuroendocrine differentiation in breast carcinoma: clinicopathological features and outcome
Aims Primary neuroendocrine (NE) breast carcinoma (BC) is an entity with a wide range of prevalence and poorly defined clinical behaviour. We evaluated the prevalence, clinicopathological features and clinical outcome of NEBC. Methods and results Immunohistochemical staining for synaptophysin and ch...
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| Veröffentlicht in: | Histopathology 2016-02, Vol.68 (3), p.422-432 |
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| creator | Bogina, Giuseppe Munari, Enrico Brunelli, Matteo Bortesi, Laura Marconi, Marcella Sommaggio, Marco Lunardi, Gianluigi Gori, Stefania Massocco, Alberto Pegoraro, Maria C Zamboni, Giuseppe |
| description | Aims
Primary neuroendocrine (NE) breast carcinoma (BC) is an entity with a wide range of prevalence and poorly defined clinical behaviour. We evaluated the prevalence, clinicopathological features and clinical outcome of NEBC.
Methods and results
Immunohistochemical staining for synaptophysin and chromogranin A was performed on whole sections from 1232 consecutive cases of invasive BC. We divided NEBC into focal (10–49% positive cells) and diffuse (≥50% positive cells) and compared the outcome of patients with NEBC with strictly matched non‐NEBC. A total of 128 BC showed NE differentiation (10.4%): 84 diffuse (6.8%) and 44 focal (3.6%). NE differentiation showed a significant association with T4 stage (P = 0.001), solid‐papillary and mucinous histotype (P |
| doi_str_mv | 10.1111/his.12766 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1760917706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1760917706</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5276-6eec29d977f1052cde2f330ca2946f9c4241a4fa8904dab0f587710a98c831523</originalsourceid><addsrcrecordid>eNp1kE1PFTEUhhsjkSu68A-YSdzIYqAf03bqzlyRS0IgfrIxac7tnEpxpr22M1H-PQMXWJh4NmfzvE_evIS8YvSAzXd4GcoB41qpJ2TBhJI1l9I8JQsqqKkpU3qXPC_lilKmBefPyC5XjDWNbhfkxxlOOWHsksshYtUF7zFjHAOMIcUqxGqdEcpYOcguxDTAu8r1IQaXNjBepj79DA76yiOMU8ZSQeyqNI0uDfiC7HjoC768_3vk28ejr8tVfXp-fLJ8f1o7ObeuFaLjpjNae0Yldx1yLwR1wE2jvHENbxg0HlpDmw7W1MtWa0bBtK4VTHKxR95uvZucfk9YRjuE4rDvIWKaimVaUcO0pmpG3_yDXqUpx7ndTEnZUCbvhPtbyuVUSkZvNzkMkK8to_Z2cjtPbu8mn9nX98ZpPWD3SD5sPAOHW-BP6PH6_ya7OvnyoKy3iVBG_PuYgPzLKi20tBdnx3Z18f2T-LBc2c_iBhNRmjo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1755401552</pqid></control><display><type>article</type><title>Neuroendocrine differentiation in breast carcinoma: clinicopathological features and outcome</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bogina, Giuseppe ; Munari, Enrico ; Brunelli, Matteo ; Bortesi, Laura ; Marconi, Marcella ; Sommaggio, Marco ; Lunardi, Gianluigi ; Gori, Stefania ; Massocco, Alberto ; Pegoraro, Maria C ; Zamboni, Giuseppe</creator><creatorcontrib>Bogina, Giuseppe ; Munari, Enrico ; Brunelli, Matteo ; Bortesi, Laura ; Marconi, Marcella ; Sommaggio, Marco ; Lunardi, Gianluigi ; Gori, Stefania ; Massocco, Alberto ; Pegoraro, Maria C ; Zamboni, Giuseppe</creatorcontrib><description>Aims
Primary neuroendocrine (NE) breast carcinoma (BC) is an entity with a wide range of prevalence and poorly defined clinical behaviour. We evaluated the prevalence, clinicopathological features and clinical outcome of NEBC.
Methods and results
Immunohistochemical staining for synaptophysin and chromogranin A was performed on whole sections from 1232 consecutive cases of invasive BC. We divided NEBC into focal (10–49% positive cells) and diffuse (≥50% positive cells) and compared the outcome of patients with NEBC with strictly matched non‐NEBC. A total of 128 BC showed NE differentiation (10.4%): 84 diffuse (6.8%) and 44 focal (3.6%). NE differentiation showed a significant association with T4 stage (P = 0.001), solid‐papillary and mucinous histotype (P < 0.0001), G2 grading (P = 0.002), positive oestrogen receptor (ER) (P = 0.003) and progesterone receptor (PR) (P = 0.002). Almost 90% of NEBC were ER+/HER2− and more than half ER+/HER2−/Ki67≥14%. Kaplan–Meier analysis revealed that patients with NEBC showed worse disease‐free survival (DFS) (P = 0.04) compared to matched non‐NEBC. We did not find significant differences regarding clinicopathological features, DFS and CSS between diffuse and focal neuroendocrine BC.
Conclusions
This study demonstrates that NEBC represents 7–10% of invasive BC and that NE differentiation does not affect the prognosis of BC in terms of CSS.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.12766</identifier><identifier>PMID: 26114478</identifier><identifier>CODEN: HISTDD</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; breast ; Breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; cancer ; Carcinoma, Neuroendocrine - metabolism ; Carcinoma, Neuroendocrine - pathology ; Chromogranin A - metabolism ; Clinical outcomes ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Medical prognosis ; Middle Aged ; neuroendocrine ; outcome ; Prognosis ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Synaptophysin - metabolism</subject><ispartof>Histopathology, 2016-02, Vol.68 (3), p.422-432</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5276-6eec29d977f1052cde2f330ca2946f9c4241a4fa8904dab0f587710a98c831523</citedby><cites>FETCH-LOGICAL-c5276-6eec29d977f1052cde2f330ca2946f9c4241a4fa8904dab0f587710a98c831523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhis.12766$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhis.12766$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26114478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bogina, Giuseppe</creatorcontrib><creatorcontrib>Munari, Enrico</creatorcontrib><creatorcontrib>Brunelli, Matteo</creatorcontrib><creatorcontrib>Bortesi, Laura</creatorcontrib><creatorcontrib>Marconi, Marcella</creatorcontrib><creatorcontrib>Sommaggio, Marco</creatorcontrib><creatorcontrib>Lunardi, Gianluigi</creatorcontrib><creatorcontrib>Gori, Stefania</creatorcontrib><creatorcontrib>Massocco, Alberto</creatorcontrib><creatorcontrib>Pegoraro, Maria C</creatorcontrib><creatorcontrib>Zamboni, Giuseppe</creatorcontrib><title>Neuroendocrine differentiation in breast carcinoma: clinicopathological features and outcome</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Primary neuroendocrine (NE) breast carcinoma (BC) is an entity with a wide range of prevalence and poorly defined clinical behaviour. We evaluated the prevalence, clinicopathological features and clinical outcome of NEBC.
Methods and results
Immunohistochemical staining for synaptophysin and chromogranin A was performed on whole sections from 1232 consecutive cases of invasive BC. We divided NEBC into focal (10–49% positive cells) and diffuse (≥50% positive cells) and compared the outcome of patients with NEBC with strictly matched non‐NEBC. A total of 128 BC showed NE differentiation (10.4%): 84 diffuse (6.8%) and 44 focal (3.6%). NE differentiation showed a significant association with T4 stage (P = 0.001), solid‐papillary and mucinous histotype (P < 0.0001), G2 grading (P = 0.002), positive oestrogen receptor (ER) (P = 0.003) and progesterone receptor (PR) (P = 0.002). Almost 90% of NEBC were ER+/HER2− and more than half ER+/HER2−/Ki67≥14%. Kaplan–Meier analysis revealed that patients with NEBC showed worse disease‐free survival (DFS) (P = 0.04) compared to matched non‐NEBC. We did not find significant differences regarding clinicopathological features, DFS and CSS between diffuse and focal neuroendocrine BC.
Conclusions
This study demonstrates that NEBC represents 7–10% of invasive BC and that NE differentiation does not affect the prognosis of BC in terms of CSS.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>breast</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>cancer</subject><subject>Carcinoma, Neuroendocrine - metabolism</subject><subject>Carcinoma, Neuroendocrine - pathology</subject><subject>Chromogranin A - metabolism</subject><subject>Clinical outcomes</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>neuroendocrine</subject><subject>outcome</subject><subject>Prognosis</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Synaptophysin - metabolism</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PFTEUhhsjkSu68A-YSdzIYqAf03bqzlyRS0IgfrIxac7tnEpxpr22M1H-PQMXWJh4NmfzvE_evIS8YvSAzXd4GcoB41qpJ2TBhJI1l9I8JQsqqKkpU3qXPC_lilKmBefPyC5XjDWNbhfkxxlOOWHsksshYtUF7zFjHAOMIcUqxGqdEcpYOcguxDTAu8r1IQaXNjBepj79DA76yiOMU8ZSQeyqNI0uDfiC7HjoC768_3vk28ejr8tVfXp-fLJ8f1o7ObeuFaLjpjNae0Yldx1yLwR1wE2jvHENbxg0HlpDmw7W1MtWa0bBtK4VTHKxR95uvZucfk9YRjuE4rDvIWKaimVaUcO0pmpG3_yDXqUpx7ndTEnZUCbvhPtbyuVUSkZvNzkMkK8to_Z2cjtPbu8mn9nX98ZpPWD3SD5sPAOHW-BP6PH6_ya7OvnyoKy3iVBG_PuYgPzLKi20tBdnx3Z18f2T-LBc2c_iBhNRmjo</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Bogina, Giuseppe</creator><creator>Munari, Enrico</creator><creator>Brunelli, Matteo</creator><creator>Bortesi, Laura</creator><creator>Marconi, Marcella</creator><creator>Sommaggio, Marco</creator><creator>Lunardi, Gianluigi</creator><creator>Gori, Stefania</creator><creator>Massocco, Alberto</creator><creator>Pegoraro, Maria C</creator><creator>Zamboni, Giuseppe</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201602</creationdate><title>Neuroendocrine differentiation in breast carcinoma: clinicopathological features and outcome</title><author>Bogina, Giuseppe ; Munari, Enrico ; Brunelli, Matteo ; Bortesi, Laura ; Marconi, Marcella ; Sommaggio, Marco ; Lunardi, Gianluigi ; Gori, Stefania ; Massocco, Alberto ; Pegoraro, Maria C ; Zamboni, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5276-6eec29d977f1052cde2f330ca2946f9c4241a4fa8904dab0f587710a98c831523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>breast</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>cancer</topic><topic>Carcinoma, Neuroendocrine - metabolism</topic><topic>Carcinoma, Neuroendocrine - pathology</topic><topic>Chromogranin A - metabolism</topic><topic>Clinical outcomes</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>neuroendocrine</topic><topic>outcome</topic><topic>Prognosis</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Synaptophysin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bogina, Giuseppe</creatorcontrib><creatorcontrib>Munari, Enrico</creatorcontrib><creatorcontrib>Brunelli, Matteo</creatorcontrib><creatorcontrib>Bortesi, Laura</creatorcontrib><creatorcontrib>Marconi, Marcella</creatorcontrib><creatorcontrib>Sommaggio, Marco</creatorcontrib><creatorcontrib>Lunardi, Gianluigi</creatorcontrib><creatorcontrib>Gori, Stefania</creatorcontrib><creatorcontrib>Massocco, Alberto</creatorcontrib><creatorcontrib>Pegoraro, Maria C</creatorcontrib><creatorcontrib>Zamboni, Giuseppe</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bogina, Giuseppe</au><au>Munari, Enrico</au><au>Brunelli, Matteo</au><au>Bortesi, Laura</au><au>Marconi, Marcella</au><au>Sommaggio, Marco</au><au>Lunardi, Gianluigi</au><au>Gori, Stefania</au><au>Massocco, Alberto</au><au>Pegoraro, Maria C</au><au>Zamboni, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroendocrine differentiation in breast carcinoma: clinicopathological features and outcome</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2016-02</date><risdate>2016</risdate><volume>68</volume><issue>3</issue><spage>422</spage><epage>432</epage><pages>422-432</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><coden>HISTDD</coden><abstract>Aims
Primary neuroendocrine (NE) breast carcinoma (BC) is an entity with a wide range of prevalence and poorly defined clinical behaviour. We evaluated the prevalence, clinicopathological features and clinical outcome of NEBC.
Methods and results
Immunohistochemical staining for synaptophysin and chromogranin A was performed on whole sections from 1232 consecutive cases of invasive BC. We divided NEBC into focal (10–49% positive cells) and diffuse (≥50% positive cells) and compared the outcome of patients with NEBC with strictly matched non‐NEBC. A total of 128 BC showed NE differentiation (10.4%): 84 diffuse (6.8%) and 44 focal (3.6%). NE differentiation showed a significant association with T4 stage (P = 0.001), solid‐papillary and mucinous histotype (P < 0.0001), G2 grading (P = 0.002), positive oestrogen receptor (ER) (P = 0.003) and progesterone receptor (PR) (P = 0.002). Almost 90% of NEBC were ER+/HER2− and more than half ER+/HER2−/Ki67≥14%. Kaplan–Meier analysis revealed that patients with NEBC showed worse disease‐free survival (DFS) (P = 0.04) compared to matched non‐NEBC. We did not find significant differences regarding clinicopathological features, DFS and CSS between diffuse and focal neuroendocrine BC.
Conclusions
This study demonstrates that NEBC represents 7–10% of invasive BC and that NE differentiation does not affect the prognosis of BC in terms of CSS.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26114478</pmid><doi>10.1111/his.12766</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism breast Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology cancer Carcinoma, Neuroendocrine - metabolism Carcinoma, Neuroendocrine - pathology Chromogranin A - metabolism Clinical outcomes Disease-Free Survival Female Humans Immunohistochemistry Kaplan-Meier Estimate Medical prognosis Middle Aged neuroendocrine outcome Prognosis Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Synaptophysin - metabolism |
| title | Neuroendocrine differentiation in breast carcinoma: clinicopathological features and outcome |
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