Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a

Vitamin B 12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B 12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membra...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2016-03, Vol.80 (3), p.510-513
Hauptverfasser:	Shiga, Takahiro, Kimira, Yoshifumi, Mano, Hiroshi, Kawata, Tetsunori, Tadokoro, Tadahiro, Suzuki, Tsukasa, Yamamoto, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bone disorder Bone Resorption Homeostasis inorganic phosphorus Kidney - metabolism Napi2a Osteoclasts - pathology Phosphates - metabolism Rats Sodium-Phosphate Cotransporter Proteins, Type IIa - physiology Vitamin B 12 Deficiency - physiopathology
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