Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a
Vitamin B 12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B 12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membra...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2016-03, Vol.80 (3), p.510-513 |
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| container_issue | 3 |
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| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 80 |
| creator | Shiga, Takahiro Kimira, Yoshifumi Mano, Hiroshi Kawata, Tetsunori Tadokoro, Tadahiro Suzuki, Tsukasa Yamamoto, Yuji |
| description | Vitamin B
12
deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B
12
deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B
12
deficiency suggests that vitamin B
12
plays an important role in Pi homeostasis. |
| doi_str_mv | 10.1080/09168451.2015.1095071 |
| format | Article |
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12
deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B
12
deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B
12
deficiency suggests that vitamin B
12
plays an important role in Pi homeostasis.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1080/09168451.2015.1095071</identifier><identifier>PMID: 26460967</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; bone disorder ; Bone Resorption ; Homeostasis ; inorganic phosphorus ; Kidney - metabolism ; Napi2a ; Osteoclasts - pathology ; Phosphates - metabolism ; Rats ; Sodium-Phosphate Cotransporter Proteins, Type IIa - physiology ; Vitamin B 12 Deficiency - physiopathology</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2016-03, Vol.80 (3), p.510-513</ispartof><rights>2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4181-fa8c8fd996e9b24d347d16cbbf72ccacfbb65536ba45d06f798c55f0a52495bd3</citedby><cites>FETCH-LOGICAL-c4181-fa8c8fd996e9b24d347d16cbbf72ccacfbb65536ba45d06f798c55f0a52495bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26460967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shiga, Takahiro</creatorcontrib><creatorcontrib>Kimira, Yoshifumi</creatorcontrib><creatorcontrib>Mano, Hiroshi</creatorcontrib><creatorcontrib>Kawata, Tetsunori</creatorcontrib><creatorcontrib>Tadokoro, Tadahiro</creatorcontrib><creatorcontrib>Suzuki, Tsukasa</creatorcontrib><creatorcontrib>Yamamoto, Yuji</creatorcontrib><title>Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Vitamin B
12
deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B
12
deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B
12
deficiency suggests that vitamin B
12
plays an important role in Pi homeostasis.</description><subject>Animals</subject><subject>bone disorder</subject><subject>Bone Resorption</subject><subject>Homeostasis</subject><subject>inorganic phosphorus</subject><subject>Kidney - metabolism</subject><subject>Napi2a</subject><subject>Osteoclasts - pathology</subject><subject>Phosphates - metabolism</subject><subject>Rats</subject><subject>Sodium-Phosphate Cotransporter Proteins, Type IIa - physiology</subject><subject>Vitamin B 12 Deficiency - physiopathology</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi1ERZfCI4B85JJiZ2MnvgFVC0hVuQBXazy2wSixg52A9iV4Zhx22yMH29LMN__I_0_IC84uORvYa6a4HDrBL1vGRS0pwXr-iOz4vusbqbr-MdltTLNB5-RpKT8YqwXBn5DzVnaSKdnvyJ-vYYEpRPqOt9Q6HzC4iIcmRLuiszREzA6Ko8nTVBaXcISyBKQmRUezKynPS0iRIqyl8uZAwcSUJxhrN_67H5iqEWrvG8QqMH9PpZ68FvorAL2DObTwjJx5GIt7fnovyJeb689XH5rbT-8_Xr29bbDjA288DDh4q5R0yrSdrX-2XKIxvm8RAb0xUoi9NNAJy6Tv1YBCeAai7ZQwdn9BXh1155x-rq4segoF3ThCdGktmvdy84oNvKLiiGJOpWTn9ZzDBPmgOdNbFPo-Cr1FoU9R1LmXpxWrmZx9mLr3vgJvjkCIfjPsd8qj1QscxpR9hoih6P3_d_wF4vebhQ</recordid><startdate>20160303</startdate><enddate>20160303</enddate><creator>Shiga, Takahiro</creator><creator>Kimira, Yoshifumi</creator><creator>Mano, Hiroshi</creator><creator>Kawata, Tetsunori</creator><creator>Tadokoro, Tadahiro</creator><creator>Suzuki, Tsukasa</creator><creator>Yamamoto, Yuji</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160303</creationdate><title>Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a</title><author>Shiga, Takahiro ; Kimira, Yoshifumi ; Mano, Hiroshi ; Kawata, Tetsunori ; Tadokoro, Tadahiro ; Suzuki, Tsukasa ; Yamamoto, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4181-fa8c8fd996e9b24d347d16cbbf72ccacfbb65536ba45d06f798c55f0a52495bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>bone disorder</topic><topic>Bone Resorption</topic><topic>Homeostasis</topic><topic>inorganic phosphorus</topic><topic>Kidney - metabolism</topic><topic>Napi2a</topic><topic>Osteoclasts - pathology</topic><topic>Phosphates - metabolism</topic><topic>Rats</topic><topic>Sodium-Phosphate Cotransporter Proteins, Type IIa - physiology</topic><topic>Vitamin B 12 Deficiency - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiga, Takahiro</creatorcontrib><creatorcontrib>Kimira, Yoshifumi</creatorcontrib><creatorcontrib>Mano, Hiroshi</creatorcontrib><creatorcontrib>Kawata, Tetsunori</creatorcontrib><creatorcontrib>Tadokoro, Tadahiro</creatorcontrib><creatorcontrib>Suzuki, Tsukasa</creatorcontrib><creatorcontrib>Yamamoto, Yuji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiga, Takahiro</au><au>Kimira, Yoshifumi</au><au>Mano, Hiroshi</au><au>Kawata, Tetsunori</au><au>Tadokoro, Tadahiro</au><au>Suzuki, Tsukasa</au><au>Yamamoto, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2016-03-03</date><risdate>2016</risdate><volume>80</volume><issue>3</issue><spage>510</spage><epage>513</epage><pages>510-513</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Vitamin B
12
deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B
12
deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B
12
deficiency suggests that vitamin B
12
plays an important role in Pi homeostasis.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>26460967</pmid><doi>10.1080/09168451.2015.1095071</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2016-03, Vol.80 (3), p.510-513 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1760915081 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles |
| subjects | Animals bone disorder Bone Resorption Homeostasis inorganic phosphorus Kidney - metabolism Napi2a Osteoclasts - pathology Phosphates - metabolism Rats Sodium-Phosphate Cotransporter Proteins, Type IIa - physiology Vitamin B 12 Deficiency - physiopathology |
| title | Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a |
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