Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA–derived small RNAs (tsRNAs), mainly from 5’ transfer RNA...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2016-01, Vol.351 (6271), p.397-400
Hauptverfasser:	Chen, Qi, Yan, Menghong, Cao, Zhonghong, Li, Xin, Zhang, Yunfang, Shi, Junchao, Feng, Gui-hai, Peng, Hongying, Zhang, Xudong, Zhang, Ying, Qian, Jingjing, Duan, Enkui, Zhai, Qiwei, Zhou, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet Diet, High-Fat - adverse effects DNA Methylation Epigenesis, Genetic Fathers Fractions GC Rich Sequence Genotype & phenotype Male Metabolic Diseases - genetics Metabolic disorders Mice Mice, Inbred C57BL Models, Animal Ribonucleic acid RNA RNA, Transfer - genetics Sperm Spermatozoa
Online-Zugang:	Volltext
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