Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA–derived small RNAs (tsRNAs), mainly from 5’ transfer RNA...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2016-01, Vol.351 (6271), p.397-400 |
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| creator | Chen, Qi Yan, Menghong Cao, Zhonghong Li, Xin Zhang, Yunfang Shi, Junchao Feng, Gui-hai Peng, Hongying Zhang, Xudong Zhang, Ying Qian, Jingjing Duan, Enkui Zhai, Qiwei Zhou, Qi |
| description | Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA–derived small RNAs (tsRNAs), mainly from 5’ transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modifications. Injection of sperm tsRNA fractions from HFD males into normal zygotes generated metabolic disorders in the F₁ offspring and altered gene expression of metabolic pathways in early embryos and islets of F₁ offspring, which was unrelated to DNA methylation at CpG-enriched regions. Hence, sperm tsRNAs represent a paternal epigenetic factor that may mediate intergenerational inheritance of diet-induced metabolic disorders. |
| doi_str_mv | 10.1126/science.aad7977 |
| format | Article |
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In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA–derived small RNAs (tsRNAs), mainly from 5’ transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modifications. Injection of sperm tsRNA fractions from HFD males into normal zygotes generated metabolic disorders in the F₁ offspring and altered gene expression of metabolic pathways in early embryos and islets of F₁ offspring, which was unrelated to DNA methylation at CpG-enriched regions. Hence, sperm tsRNAs represent a paternal epigenetic factor that may mediate intergenerational inheritance of diet-induced metabolic disorders.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.aad7977</identifier><identifier>PMID: 26721680</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Diet ; Diet, High-Fat - adverse effects ; DNA Methylation ; Epigenesis, Genetic ; Fathers ; Fractions ; GC Rich Sequence ; Genotype & phenotype ; Male ; Metabolic Diseases - genetics ; Metabolic disorders ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Ribonucleic acid ; RNA ; RNA, Transfer - genetics ; Sperm ; Spermatozoa</subject><ispartof>Science (American Association for the Advancement of Science), 2016-01, Vol.351 (6271), p.397-400</ispartof><rights>Copyright © 2016 American Association for the Advancement of Science</rights><rights>Copyright © 2016, American Association for the Advancement of Science.</rights><rights>Copyright © 2016, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-f0015ddfc7d108c9d4787f8181fe51424520fe32ac0aa41a69a6f19de50dcb383</citedby><cites>FETCH-LOGICAL-c454t-f0015ddfc7d108c9d4787f8181fe51424520fe32ac0aa41a69a6f19de50dcb383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24741359$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24741359$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26721680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Yan, Menghong</creatorcontrib><creatorcontrib>Cao, Zhonghong</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Zhang, Yunfang</creatorcontrib><creatorcontrib>Shi, Junchao</creatorcontrib><creatorcontrib>Feng, Gui-hai</creatorcontrib><creatorcontrib>Peng, Hongying</creatorcontrib><creatorcontrib>Zhang, Xudong</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Qian, Jingjing</creatorcontrib><creatorcontrib>Duan, Enkui</creatorcontrib><creatorcontrib>Zhai, Qiwei</creatorcontrib><creatorcontrib>Zhou, Qi</creatorcontrib><title>Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA–derived small RNAs (tsRNAs), mainly from 5’ transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modifications. Injection of sperm tsRNA fractions from HFD males into normal zygotes generated metabolic disorders in the F₁ offspring and altered gene expression of metabolic pathways in early embryos and islets of F₁ offspring, which was unrelated to DNA methylation at CpG-enriched regions. Hence, sperm tsRNAs represent a paternal epigenetic factor that may mediate intergenerational inheritance of diet-induced metabolic disorders.</description><subject>Animals</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>DNA Methylation</subject><subject>Epigenesis, Genetic</subject><subject>Fathers</subject><subject>Fractions</subject><subject>GC Rich Sequence</subject><subject>Genotype & phenotype</subject><subject>Male</subject><subject>Metabolic Diseases - genetics</subject><subject>Metabolic disorders</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Models, Animal</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Transfer - genetics</subject><subject>Sperm</subject><subject>Spermatozoa</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFP3TAMgCO0CR6MMyemSLtwKdht0rRHhAabhDaJbRcuVV7ijDy1zSNJD_v3BL3HJu1kyf5sy58ZO0O4RKzbq2Q8zYYutbaqV-qArRB6WfU1NO_YCqBpqw6UPGLHKW0ASq1vDtlR3aoa2w5W7PHHluLEc3r4dp24CXOOfr1k4jlwP2eKv2mmqLMPsx5L5omiz7qs5MFxPXNtnhcfyfKJsl6H0RtufQrRUvzA3js9JjrdxxP26_bzz5sv1f33u6831_eVEVLkygGgtNYZZRE601uhOuU67NCRRFELWYOjptYGtBao2163DntLEqxZN11zwi52c7cxPC-U8jD5ZGgc9UxhSQOqFnoU0KqCfvoP3YQllsteKdkVg0Jioa52lIkhpUhu2EY_6fhnQBhetQ977cNee-n4uJ-7rCeyf_k3zwU43wGblEP8VxdKYFN-8gKO84p4</recordid><startdate>20160122</startdate><enddate>20160122</enddate><creator>Chen, Qi</creator><creator>Yan, Menghong</creator><creator>Cao, Zhonghong</creator><creator>Li, Xin</creator><creator>Zhang, Yunfang</creator><creator>Shi, Junchao</creator><creator>Feng, Gui-hai</creator><creator>Peng, Hongying</creator><creator>Zhang, Xudong</creator><creator>Zhang, Ying</creator><creator>Qian, Jingjing</creator><creator>Duan, Enkui</creator><creator>Zhai, Qiwei</creator><creator>Zhou, Qi</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20160122</creationdate><title>Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder</title><author>Chen, Qi ; Yan, Menghong ; Cao, Zhonghong ; Li, Xin ; Zhang, Yunfang ; Shi, Junchao ; Feng, Gui-hai ; Peng, Hongying ; Zhang, Xudong ; Zhang, Ying ; Qian, Jingjing ; Duan, Enkui ; Zhai, Qiwei ; Zhou, Qi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-f0015ddfc7d108c9d4787f8181fe51424520fe32ac0aa41a69a6f19de50dcb383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Diet</topic><topic>Diet, High-Fat - 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In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA–derived small RNAs (tsRNAs), mainly from 5’ transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modifications. Injection of sperm tsRNA fractions from HFD males into normal zygotes generated metabolic disorders in the F₁ offspring and altered gene expression of metabolic pathways in early embryos and islets of F₁ offspring, which was unrelated to DNA methylation at CpG-enriched regions. Hence, sperm tsRNAs represent a paternal epigenetic factor that may mediate intergenerational inheritance of diet-induced metabolic disorders.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>26721680</pmid><doi>10.1126/science.aad7977</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Diet Diet, High-Fat - adverse effects DNA Methylation Epigenesis, Genetic Fathers Fractions GC Rich Sequence Genotype & phenotype Male Metabolic Diseases - genetics Metabolic disorders Mice Mice, Inbred C57BL Models, Animal Ribonucleic acid RNA RNA, Transfer - genetics Sperm Spermatozoa |
| title | Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder |
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