Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Mice

A healthy conjunctiva secreting mucins is essential for maintaining the integrity of the ocular surface epithelium. We used Cu, Zn-superoxide dismutase 1-deficient mice (Sod1-/- mice) and investigated the effect of oxidative stress on the tear function, conjunctival phenotype, and ocular surface muc...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2015-12, Vol.56 (13), p.8382-8391
Hauptverfasser:	Kojima, Takashi, Dogru, Murat, Ibrahim, Osama M A, Wakamatsu, Tais Hitomi, Ito, Masataka, Igarashi, Ayako, Inaba, Takaaki, Shimizu, Takahiko, Shirasawa, Takuji, Shimazaki, Jun, Tsubota, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Conjunctiva - cytology Conjunctiva - metabolism Copper - metabolism Male Mice Mice, Knockout Mucins - biosynthesis Oxidative Stress Superoxide Dismutase - metabolism Superoxide Dismutase-1 Tears - metabolism Zinc - metabolism
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