Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer
Background Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer...
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| Veröffentlicht in: | Annals of surgical oncology 2016-02, Vol.23 (2), p.525-533 |
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| container_title | Annals of surgical oncology |
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| creator | Sakurai, Katsunobu Ohira, Masaichi Tamura, Tatsuro Toyokawa, Takahiro Amano, Ryosuke Kubo, Naoshi Tanaka, Hiroaki Muguruma, Kazuya Yashiro, Masakazu Maeda, Kiyoshi Hirakawa, Kosei |
| description | Background
Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigated.
Methods
The study reviewed 594 patients treated for GC by gastrectomy at the authors’ hospital between January, 2004 and December, 2010. Onodera’s prognostic nutritional index (PNI) was invoked, using an optimal cut point to group patients as having high (PNI > 45;
n
= 449) or low (PNI ≤ 45;
n
= 145) nutritional status. Clinicopathologic features, perioperative results, and long-term outcomes, including cause of death, were compared.
Results
Multivariate analysis of 5-year overall survival (OS) and disease-specific survival (DSS) indicated that low PNI was independently associated with unfavorable outcomes for patients with GC. In subgroup analysis, the 5-year OS and DSS rates for patients with GC at stages 1 and 2 were significantly worse in the low PNI group than in the high PNI group. Although wound and extrasurgical field infections also tended to be more frequent in the low PNI group, postoperative intraabdominal infections did not differ significantly by group.
Conclusions
Preoperative PNI may have merit as a gauge of prognosis for patients with GC at stages 1 and 2, but PNI and postoperative morbidity showed no correlation in this setting. |
| doi_str_mv | 10.1245/s10434-015-4814-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1760910016</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3925950691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-a798c1e70d4cab4de91873715c4a0a50009928a32b23c0e5ea193ed92f0acfb33</originalsourceid><addsrcrecordid>eNp1kd1rFDEUxYMo9kP_AF8k4EtfRm--JpPHsmhbWOyC9TlkM3dqlp3JNsko_e-b7VYpBZ8S7vmdc0kOIR8YfGZcqi-ZgRSyAaYa2THZ6FfkmKk6kW3HXtc7tF1jeKuOyEnOGwCmBai35Ii3AjQXcEzuVwn74Ev4jXQVC04luC2NA63zuMPkHpXvc0mhhDhV7UdxZc40THQZp9vmBtNIr-fi41gTUtyg34OZDjHRVbXXyEz_hPKLXrhcYzxduMljekfeDG6b8f3TeUp-fvt6s7hsltcXV4vzZeOl5KVx2nSeoYZeereWPRrWaaGZ8tKBUwBgDO-c4GsuPKBCx4zA3vABnB_WQpySs0PuLsW7GXOxY8get1s3YZyzZboFw-rftBX99ALdxDnVR-8p1YGpEKsUO1A-xZwTDnaXwujSvWVg973YQy-29mL3vVhdPR-fkuf1iP0_x98iKsAPQK7SdIvp2er_pj4AonyZHw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1758090161</pqid></control><display><type>article</type><title>Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Sakurai, Katsunobu ; Ohira, Masaichi ; Tamura, Tatsuro ; Toyokawa, Takahiro ; Amano, Ryosuke ; Kubo, Naoshi ; Tanaka, Hiroaki ; Muguruma, Kazuya ; Yashiro, Masakazu ; Maeda, Kiyoshi ; Hirakawa, Kosei</creator><creatorcontrib>Sakurai, Katsunobu ; Ohira, Masaichi ; Tamura, Tatsuro ; Toyokawa, Takahiro ; Amano, Ryosuke ; Kubo, Naoshi ; Tanaka, Hiroaki ; Muguruma, Kazuya ; Yashiro, Masakazu ; Maeda, Kiyoshi ; Hirakawa, Kosei</creatorcontrib><description>Background
Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigated.
Methods
The study reviewed 594 patients treated for GC by gastrectomy at the authors’ hospital between January, 2004 and December, 2010. Onodera’s prognostic nutritional index (PNI) was invoked, using an optimal cut point to group patients as having high (PNI > 45;
n
= 449) or low (PNI ≤ 45;
n
= 145) nutritional status. Clinicopathologic features, perioperative results, and long-term outcomes, including cause of death, were compared.
Results
Multivariate analysis of 5-year overall survival (OS) and disease-specific survival (DSS) indicated that low PNI was independently associated with unfavorable outcomes for patients with GC. In subgroup analysis, the 5-year OS and DSS rates for patients with GC at stages 1 and 2 were significantly worse in the low PNI group than in the high PNI group. Although wound and extrasurgical field infections also tended to be more frequent in the low PNI group, postoperative intraabdominal infections did not differ significantly by group.
Conclusions
Preoperative PNI may have merit as a gauge of prognosis for patients with GC at stages 1 and 2, but PNI and postoperative morbidity showed no correlation in this setting.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-015-4814-7</identifier><identifier>PMID: 26307230</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Female ; Follow-Up Studies ; Gastrectomy - adverse effects ; Gastrointestinal Oncology ; Humans ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Neoplasm Invasiveness ; Neoplasm Staging ; Nutrition Assessment ; Nutritional Status ; Oncology ; Postoperative Complications ; Preoperative Period ; Prognosis ; Risk Factors ; Stomach Neoplasms - secondary ; Stomach Neoplasms - surgery ; Surgery ; Surgical Oncology ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2016-02, Vol.23 (2), p.525-533</ispartof><rights>Society of Surgical Oncology 2015</rights><rights>Society of Surgical Oncology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-a798c1e70d4cab4de91873715c4a0a50009928a32b23c0e5ea193ed92f0acfb33</citedby><cites>FETCH-LOGICAL-c442t-a798c1e70d4cab4de91873715c4a0a50009928a32b23c0e5ea193ed92f0acfb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-015-4814-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-015-4814-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26307230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakurai, Katsunobu</creatorcontrib><creatorcontrib>Ohira, Masaichi</creatorcontrib><creatorcontrib>Tamura, Tatsuro</creatorcontrib><creatorcontrib>Toyokawa, Takahiro</creatorcontrib><creatorcontrib>Amano, Ryosuke</creatorcontrib><creatorcontrib>Kubo, Naoshi</creatorcontrib><creatorcontrib>Tanaka, Hiroaki</creatorcontrib><creatorcontrib>Muguruma, Kazuya</creatorcontrib><creatorcontrib>Yashiro, Masakazu</creatorcontrib><creatorcontrib>Maeda, Kiyoshi</creatorcontrib><creatorcontrib>Hirakawa, Kosei</creatorcontrib><title>Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigated.
Methods
The study reviewed 594 patients treated for GC by gastrectomy at the authors’ hospital between January, 2004 and December, 2010. Onodera’s prognostic nutritional index (PNI) was invoked, using an optimal cut point to group patients as having high (PNI > 45;
n
= 449) or low (PNI ≤ 45;
n
= 145) nutritional status. Clinicopathologic features, perioperative results, and long-term outcomes, including cause of death, were compared.
Results
Multivariate analysis of 5-year overall survival (OS) and disease-specific survival (DSS) indicated that low PNI was independently associated with unfavorable outcomes for patients with GC. In subgroup analysis, the 5-year OS and DSS rates for patients with GC at stages 1 and 2 were significantly worse in the low PNI group than in the high PNI group. Although wound and extrasurgical field infections also tended to be more frequent in the low PNI group, postoperative intraabdominal infections did not differ significantly by group.
Conclusions
Preoperative PNI may have merit as a gauge of prognosis for patients with GC at stages 1 and 2, but PNI and postoperative morbidity showed no correlation in this setting.</description><subject>Aged</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrectomy - adverse effects</subject><subject>Gastrointestinal Oncology</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Oncology</subject><subject>Postoperative Complications</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - secondary</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kd1rFDEUxYMo9kP_AF8k4EtfRm--JpPHsmhbWOyC9TlkM3dqlp3JNsko_e-b7VYpBZ8S7vmdc0kOIR8YfGZcqi-ZgRSyAaYa2THZ6FfkmKk6kW3HXtc7tF1jeKuOyEnOGwCmBai35Ii3AjQXcEzuVwn74Ev4jXQVC04luC2NA63zuMPkHpXvc0mhhDhV7UdxZc40THQZp9vmBtNIr-fi41gTUtyg34OZDjHRVbXXyEz_hPKLXrhcYzxduMljekfeDG6b8f3TeUp-fvt6s7hsltcXV4vzZeOl5KVx2nSeoYZeereWPRrWaaGZ8tKBUwBgDO-c4GsuPKBCx4zA3vABnB_WQpySs0PuLsW7GXOxY8get1s3YZyzZboFw-rftBX99ALdxDnVR-8p1YGpEKsUO1A-xZwTDnaXwujSvWVg973YQy-29mL3vVhdPR-fkuf1iP0_x98iKsAPQK7SdIvp2er_pj4AonyZHw</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Sakurai, Katsunobu</creator><creator>Ohira, Masaichi</creator><creator>Tamura, Tatsuro</creator><creator>Toyokawa, Takahiro</creator><creator>Amano, Ryosuke</creator><creator>Kubo, Naoshi</creator><creator>Tanaka, Hiroaki</creator><creator>Muguruma, Kazuya</creator><creator>Yashiro, Masakazu</creator><creator>Maeda, Kiyoshi</creator><creator>Hirakawa, Kosei</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer</title><author>Sakurai, Katsunobu ; Ohira, Masaichi ; Tamura, Tatsuro ; Toyokawa, Takahiro ; Amano, Ryosuke ; Kubo, Naoshi ; Tanaka, Hiroaki ; Muguruma, Kazuya ; Yashiro, Masakazu ; Maeda, Kiyoshi ; Hirakawa, Kosei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-a798c1e70d4cab4de91873715c4a0a50009928a32b23c0e5ea193ed92f0acfb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrectomy - adverse effects</topic><topic>Gastrointestinal Oncology</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Oncology</topic><topic>Postoperative Complications</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - secondary</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakurai, Katsunobu</creatorcontrib><creatorcontrib>Ohira, Masaichi</creatorcontrib><creatorcontrib>Tamura, Tatsuro</creatorcontrib><creatorcontrib>Toyokawa, Takahiro</creatorcontrib><creatorcontrib>Amano, Ryosuke</creatorcontrib><creatorcontrib>Kubo, Naoshi</creatorcontrib><creatorcontrib>Tanaka, Hiroaki</creatorcontrib><creatorcontrib>Muguruma, Kazuya</creatorcontrib><creatorcontrib>Yashiro, Masakazu</creatorcontrib><creatorcontrib>Maeda, Kiyoshi</creatorcontrib><creatorcontrib>Hirakawa, Kosei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakurai, Katsunobu</au><au>Ohira, Masaichi</au><au>Tamura, Tatsuro</au><au>Toyokawa, Takahiro</au><au>Amano, Ryosuke</au><au>Kubo, Naoshi</au><au>Tanaka, Hiroaki</au><au>Muguruma, Kazuya</au><au>Yashiro, Masakazu</au><au>Maeda, Kiyoshi</au><au>Hirakawa, Kosei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>23</volume><issue>2</issue><spage>525</spage><epage>533</epage><pages>525-533</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigated.
Methods
The study reviewed 594 patients treated for GC by gastrectomy at the authors’ hospital between January, 2004 and December, 2010. Onodera’s prognostic nutritional index (PNI) was invoked, using an optimal cut point to group patients as having high (PNI > 45;
n
= 449) or low (PNI ≤ 45;
n
= 145) nutritional status. Clinicopathologic features, perioperative results, and long-term outcomes, including cause of death, were compared.
Results
Multivariate analysis of 5-year overall survival (OS) and disease-specific survival (DSS) indicated that low PNI was independently associated with unfavorable outcomes for patients with GC. In subgroup analysis, the 5-year OS and DSS rates for patients with GC at stages 1 and 2 were significantly worse in the low PNI group than in the high PNI group. Although wound and extrasurgical field infections also tended to be more frequent in the low PNI group, postoperative intraabdominal infections did not differ significantly by group.
Conclusions
Preoperative PNI may have merit as a gauge of prognosis for patients with GC at stages 1 and 2, but PNI and postoperative morbidity showed no correlation in this setting.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26307230</pmid><doi>10.1245/s10434-015-4814-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2016-02, Vol.23 (2), p.525-533 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Female Follow-Up Studies Gastrectomy - adverse effects Gastrointestinal Oncology Humans Lymphatic Metastasis Male Medicine Medicine & Public Health Neoplasm Invasiveness Neoplasm Staging Nutrition Assessment Nutritional Status Oncology Postoperative Complications Preoperative Period Prognosis Risk Factors Stomach Neoplasms - secondary Stomach Neoplasms - surgery Surgery Surgical Oncology Survival Rate |
| title | Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer |
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