Poly(ADP-ribose)polymerase 1 inhibition protects against age-dependent endothelial dysfunction

Summary Age‐related endothelial dysfunction is closely associated with the local production of reactive oxygen species (ROS) within and in the vicinity of the vascular endothelium. Oxidant‐induced DNA damage can activate the nuclear enzyme poly(ADP‐ribose) polymerase 1 (PARP‐1), leading to endotheli...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2015-12, Vol.42 (12), p.1266-1274
Hauptverfasser:	Zhang, Guang-hao, Chao, Min, Hui, Long-hua, Xu, Dong Ling, Cai, We-li, Zheng, Jie, Gao, Min, Zhang, Ming-xiang, Wang, Juan, Lu, Qing-hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects aging Aging - drug effects Aging - genetics Aging - metabolism Angiotensin II - pharmacology Animals arginase-2 Cell Nucleus - drug effects Cell Nucleus - metabolism endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Gene Deletion Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Humans Male Mice NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type I - metabolism Nitric Oxide Synthase Type III - metabolism Nitriles - pharmacology PARP-1 Poly (ADP-Ribose) Polymerase-1 - deficiency Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - metabolism Sulfones - pharmacology Superoxides - metabolism
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