Multipotent mesenchymal stromal cells promote tumor growth in distinct colorectal cancer cells by a β1‐integrin‐dependent mechanism

Tumor–stroma interactions play an essential role in the biology of colorectal carcinoma (CRC). Multipotent mesenchymal stromal cells (MSC) may represent a pivotal part of the stroma in CRC, but little is known about the specific interaction of MSC with CRC cells derived from tumors with different mu...

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Veröffentlicht in:	International journal of cancer 2016-02, Vol.138 (4), p.964-975
Hauptverfasser:	Widder, Miriam, Lützkendorf, Jana, Caysa, Henrike, Unverzagt, Susanne, Wickenhauser, Claudia, Benndorf, Ralf A., Schmoll, Hans‐Joachim, Müller‐Tidow, Carsten, Müller, Thomas, Müller, Lutz P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line, Tumor Coculture Techniques Colorectal Neoplasms - pathology CRC Gene Knockdown Techniques growth promotion Heterografts Humans Integrin beta1 - metabolism Male Mesenchymal Stromal Cells - metabolism Mice Mice, Nude MSC Reverse Transcriptase Polymerase Chain Reaction Tumor Microenvironment - physiology tumor‐stroma‐interactions β1‐integrin
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