Humoral Immunity to Cytomegalovirus Glycoprotein B in Patients With Breast Cancer and Matched Controls: Contribution of Immunoglobulin γ, κ, and Fcγ Receptor Genes
Increasing evidence implicates human cytomegalovirus (HCMV) in the etiopathogenesis of breast cancer. Antibodies to this virus in patients with breast cancer have been reported, but no large-scale studies have been conducted to determine whether the antibody levels differ between patients and matche...
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| Veröffentlicht in: | The Journal of infectious diseases 2016-02, Vol.213 (4), p.611-617 |
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| container_title | The Journal of infectious diseases |
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| creator | Pandey, Janardan P. Gao, Guimin Namboodiri, Aryan M. Iwasaki, Motoki Kasuga, Yoshio Hamada, Gerson S. Tsugane, Shoichiro |
| description | Increasing evidence implicates human cytomegalovirus (HCMV) in the etiopathogenesis of breast cancer. Antibodies to this virus in patients with breast cancer have been reported, but no large-scale studies have been conducted to determine whether the antibody levels differ between patients and matched controls. Using specimens from a large (1712 subjects) multiethnic case-control study, we aimed to determine whether the levels of antibodies to the HCMV glycoprotein B (gB) differed between patients and controls and whether they were associated with particular immunoglobulin γ marker (GM), κ marker (KM), and Fcγ receptor (FcγR) genotypes. A combined analysis showed that anti-gB immunoglobulin G antibody levels were higher in healthy controls than in patients (P < .0001). Stratified analyses showed population-specific differences in the magnitude of anti-gB antibody responsiveness and in the contribution of particular GM, KM, and FcγR genotypes to these responses. These findings may have implications for HCMV-based immunotherapy against breast cancer and other HCMV-associated diseases. |
| doi_str_mv | 10.1093/infdis/jiv472 |
| format | Article |
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Antibodies to this virus in patients with breast cancer have been reported, but no large-scale studies have been conducted to determine whether the antibody levels differ between patients and matched controls. Using specimens from a large (1712 subjects) multiethnic case-control study, we aimed to determine whether the levels of antibodies to the HCMV glycoprotein B (gB) differed between patients and controls and whether they were associated with particular immunoglobulin γ marker (GM), κ marker (KM), and Fcγ receptor (FcγR) genotypes. A combined analysis showed that anti-gB immunoglobulin G antibody levels were higher in healthy controls than in patients (P < .0001). Stratified analyses showed population-specific differences in the magnitude of anti-gB antibody responsiveness and in the contribution of particular GM, KM, and FcγR genotypes to these responses. 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Antibodies to this virus in patients with breast cancer have been reported, but no large-scale studies have been conducted to determine whether the antibody levels differ between patients and matched controls. Using specimens from a large (1712 subjects) multiethnic case-control study, we aimed to determine whether the levels of antibodies to the HCMV glycoprotein B (gB) differed between patients and controls and whether they were associated with particular immunoglobulin γ marker (GM), κ marker (KM), and Fcγ receptor (FcγR) genotypes. A combined analysis showed that anti-gB immunoglobulin G antibody levels were higher in healthy controls than in patients (P < .0001). Stratified analyses showed population-specific differences in the magnitude of anti-gB antibody responsiveness and in the contribution of particular GM, KM, and FcγR genotypes to these responses. These findings may have implications for HCMV-based immunotherapy against breast cancer and other HCMV-associated diseases.</description><subject>Antibodies, Viral - blood</subject><subject>Breast Neoplasms - complications</subject><subject>Case-Control Studies</subject><subject>Cytomegalovirus Infections - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulins - genetics</subject><subject>Receptors, IgG - genetics</subject><subject>Viral Envelope Proteins - immunology</subject><subject>VIRUSES</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc9O3DAQhy1EBcu2xx6LfORAiv_EccINorIgUbWqWvUYOc4EvHLsxXaQ9oX6Atx4iH2mpg2lF9vSfP6NZj6E3lPykZKKnxnXdyaerc1jLtkeWlDBZVYUlO-jBSGMZbSsqkN0FOOaEJLzQh6gQ1bklIiKL9Cv63HwQVl8MwyjM2mLk8f1NvkB7pT1jyaMEa_sVvtN8AmMw5d4Or6qZMCliH-adI8vA6iYcK2choCV6_BnlfQ9dLj2LgVv4_n8Mu2YjHfY93M_f2d9O9opcPd0infPp38_X-ndE_4GGjbJB7wCB_EtetMrG-Hdy71EP64-fa-vs9svq5v64jbTXOQpk0JDWbQtJbpSJM8pdCA7KnQlIGdl3wFoVWrFgAndM8KVZCWIUlZlK1pR8CU6mXOnaR9GiKkZTNRgrXLgx9hQWZCKSDrtbomyGdXBxxigbzbBDCpsG0qaP2qaWU0zq5n445fosR2ge6X_uZiADzOwjtPc_-u5pMXkjf8GrEObHg</recordid><startdate>20160215</startdate><enddate>20160215</enddate><creator>Pandey, Janardan P.</creator><creator>Gao, Guimin</creator><creator>Namboodiri, Aryan M.</creator><creator>Iwasaki, Motoki</creator><creator>Kasuga, Yoshio</creator><creator>Hamada, Gerson S.</creator><creator>Tsugane, Shoichiro</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160215</creationdate><title>Humoral Immunity to Cytomegalovirus Glycoprotein B in Patients With Breast Cancer and Matched Controls: Contribution of Immunoglobulin γ, κ, and Fcγ Receptor Genes</title><author>Pandey, Janardan P. ; Gao, Guimin ; Namboodiri, Aryan M. ; Iwasaki, Motoki ; Kasuga, Yoshio ; Hamada, Gerson S. ; Tsugane, Shoichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-75ce86bb10c9a0441ede7d15c95e428fdeeca8ca2e25cf203a728e58798b5b563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antibodies, Viral - blood</topic><topic>Breast Neoplasms - complications</topic><topic>Case-Control Studies</topic><topic>Cytomegalovirus Infections - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulins - genetics</topic><topic>Receptors, IgG - genetics</topic><topic>Viral Envelope Proteins - immunology</topic><topic>VIRUSES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandey, Janardan P.</creatorcontrib><creatorcontrib>Gao, Guimin</creatorcontrib><creatorcontrib>Namboodiri, Aryan M.</creatorcontrib><creatorcontrib>Iwasaki, Motoki</creatorcontrib><creatorcontrib>Kasuga, Yoshio</creatorcontrib><creatorcontrib>Hamada, Gerson S.</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandey, Janardan P.</au><au>Gao, Guimin</au><au>Namboodiri, Aryan M.</au><au>Iwasaki, Motoki</au><au>Kasuga, Yoshio</au><au>Hamada, Gerson S.</au><au>Tsugane, Shoichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Humoral Immunity to Cytomegalovirus Glycoprotein B in Patients With Breast Cancer and Matched Controls: Contribution of Immunoglobulin γ, κ, and Fcγ Receptor Genes</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2016-02-15</date><risdate>2016</risdate><volume>213</volume><issue>4</issue><spage>611</spage><epage>617</epage><pages>611-617</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Increasing evidence implicates human cytomegalovirus (HCMV) in the etiopathogenesis of breast cancer. 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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Antibodies, Viral - blood Breast Neoplasms - complications Case-Control Studies Cytomegalovirus Infections - epidemiology Female Humans Immunoglobulins - genetics Receptors, IgG - genetics Viral Envelope Proteins - immunology VIRUSES |
| title | Humoral Immunity to Cytomegalovirus Glycoprotein B in Patients With Breast Cancer and Matched Controls: Contribution of Immunoglobulin γ, κ, and Fcγ Receptor Genes |
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