Heat Capacity Changes and Disorder-to-Order Transitions in Allosteric Activation

Allosteric coupling in proteins is ubiquitous but incompletely understood, particularly in systems characterized by coupling over large distances. Binding of the allosteric effector, bio-5′-AMP, to the Escherichia coli biotin protein ligase, BirA, enhances the protein’s dimerization free energy by −...

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