Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding
ABSTRACT Preclinical Research There has been recent interest in characterizing the effects of pain‐like states on motivated behaviors in order to quantify how pain modulates goal‐directed behavior and the persistence of that behavior. The current set of experiments assessed the effects of an incisio...
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| Veröffentlicht in: | Drug development research 2015-12, Vol.76 (8), p.432-441 |
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| creator | Warner, Emily Krivitsky, Rebecca Cone, Katherine Atherton, Phillip Pitre, Travis Lanpher, Janell Giuvelis, Denise Bergquist, Ivy King, Tamara Bilsky, Edward J. Stevenson, Glenn W. |
| description | ABSTRACT
Preclinical Research
There has been recent interest in characterizing the effects of pain‐like states on motivated behaviors in order to quantify how pain modulates goal‐directed behavior and the persistence of that behavior. The current set of experiments assessed the effects of an incisional postoperative pain manipulation on food‐maintained responding under a progressive‐ratio (PR) operant schedule. Independent variables included injury state (plantar incision or anesthesia control) and reinforcer type (grain pellet or sugar pellet); dependent variables were tactile sensory thresholds and response breakpoint. Once responding stabilized on the PR schedule, separate groups of rats received a single ventral hind paw incision or anesthesia (control condition). Incision significantly reduced breakpoints in rats responding for grain, but not sugar. In rats responding for sugar, tactile hypersensitivity recovered within 24 hr, indicating a faster recovery of incision‐induced tactile hypersensitivity compared to rats responding for grain, which demonstrated recovery at PD2. The NSAID analgesic, diclofenac (5.6 mg/kg) completely restored incision‐depressed PR operant responding and tactile sensitivity at 3 hr following incision. The PR schedule differentiated between sucrose and grain, suggesting that relative reinforcing efficacy may be an important determinant in detecting pain‐induced changes in motivated behavior. Drug Dev Res 76 : 432–441, 2015. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/ddr.21284 |
| format | Article |
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Preclinical Research
There has been recent interest in characterizing the effects of pain‐like states on motivated behaviors in order to quantify how pain modulates goal‐directed behavior and the persistence of that behavior. The current set of experiments assessed the effects of an incisional postoperative pain manipulation on food‐maintained responding under a progressive‐ratio (PR) operant schedule. Independent variables included injury state (plantar incision or anesthesia control) and reinforcer type (grain pellet or sugar pellet); dependent variables were tactile sensory thresholds and response breakpoint. Once responding stabilized on the PR schedule, separate groups of rats received a single ventral hind paw incision or anesthesia (control condition). Incision significantly reduced breakpoints in rats responding for grain, but not sugar. In rats responding for sugar, tactile hypersensitivity recovered within 24 hr, indicating a faster recovery of incision‐induced tactile hypersensitivity compared to rats responding for grain, which demonstrated recovery at PD2. The NSAID analgesic, diclofenac (5.6 mg/kg) completely restored incision‐depressed PR operant responding and tactile sensitivity at 3 hr following incision. The PR schedule differentiated between sucrose and grain, suggesting that relative reinforcing efficacy may be an important determinant in detecting pain‐induced changes in motivated behavior. Drug Dev Res 76 : 432–441, 2015. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 0272-4391</identifier><identifier>EISSN: 1098-2299</identifier><identifier>DOI: 10.1002/ddr.21284</identifier><identifier>PMID: 26494422</identifier><identifier>CODEN: DDREDK</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Analgesics - pharmacology ; Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Conditioning, Operant - drug effects ; Conditioning, Operant - physiology ; Diclofenac - pharmacology ; Feeding Behavior - drug effects ; Feeding Behavior - physiology ; Feeding Behavior - psychology ; Hindlimb - surgery ; Male ; Motivation ; nociception ; Nociception - drug effects ; Nociception - physiology ; operant conditioning ; Pain, Postoperative - drug therapy ; Pain, Postoperative - physiopathology ; Pain, Postoperative - psychology ; pain-depressed behavior ; postoperative incisional pain ; preclinical pain assay ; progressive ratio schedules ; Rats ; Rats, Sprague-Dawley ; Reinforcement Schedule</subject><ispartof>Drug development research, 2015-12, Vol.76 (8), p.432-441</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4964-39cc07626c25c0c2d632ef6044fa543ce1a84ce43182dcedeb5dc57971b5189d3</citedby><cites>FETCH-LOGICAL-c4964-39cc07626c25c0c2d632ef6044fa543ce1a84ce43182dcedeb5dc57971b5189d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fddr.21284$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fddr.21284$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26494422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warner, Emily</creatorcontrib><creatorcontrib>Krivitsky, Rebecca</creatorcontrib><creatorcontrib>Cone, Katherine</creatorcontrib><creatorcontrib>Atherton, Phillip</creatorcontrib><creatorcontrib>Pitre, Travis</creatorcontrib><creatorcontrib>Lanpher, Janell</creatorcontrib><creatorcontrib>Giuvelis, Denise</creatorcontrib><creatorcontrib>Bergquist, Ivy</creatorcontrib><creatorcontrib>King, Tamara</creatorcontrib><creatorcontrib>Bilsky, Edward J.</creatorcontrib><creatorcontrib>Stevenson, Glenn W.</creatorcontrib><title>Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding</title><title>Drug development research</title><addtitle>Drug Dev. Res</addtitle><description>ABSTRACT
Preclinical Research
There has been recent interest in characterizing the effects of pain‐like states on motivated behaviors in order to quantify how pain modulates goal‐directed behavior and the persistence of that behavior. The current set of experiments assessed the effects of an incisional postoperative pain manipulation on food‐maintained responding under a progressive‐ratio (PR) operant schedule. Independent variables included injury state (plantar incision or anesthesia control) and reinforcer type (grain pellet or sugar pellet); dependent variables were tactile sensory thresholds and response breakpoint. Once responding stabilized on the PR schedule, separate groups of rats received a single ventral hind paw incision or anesthesia (control condition). Incision significantly reduced breakpoints in rats responding for grain, but not sugar. In rats responding for sugar, tactile hypersensitivity recovered within 24 hr, indicating a faster recovery of incision‐induced tactile hypersensitivity compared to rats responding for grain, which demonstrated recovery at PD2. The NSAID analgesic, diclofenac (5.6 mg/kg) completely restored incision‐depressed PR operant responding and tactile sensitivity at 3 hr following incision. The PR schedule differentiated between sucrose and grain, suggesting that relative reinforcing efficacy may be an important determinant in detecting pain‐induced changes in motivated behavior. Drug Dev Res 76 : 432–441, 2015. © 2015 Wiley Periodicals, Inc.</description><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Conditioning, Operant - drug effects</subject><subject>Conditioning, Operant - physiology</subject><subject>Diclofenac - pharmacology</subject><subject>Feeding Behavior - drug effects</subject><subject>Feeding Behavior - physiology</subject><subject>Feeding Behavior - psychology</subject><subject>Hindlimb - surgery</subject><subject>Male</subject><subject>Motivation</subject><subject>nociception</subject><subject>Nociception - drug effects</subject><subject>Nociception - physiology</subject><subject>operant conditioning</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - physiopathology</subject><subject>Pain, Postoperative - psychology</subject><subject>pain-depressed behavior</subject><subject>postoperative incisional pain</subject><subject>preclinical pain assay</subject><subject>progressive ratio schedules</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reinforcement Schedule</subject><issn>0272-4391</issn><issn>1098-2299</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFuEzEQhi0EoqFw4AWQJS5w2Nb2er1rbm2TlIoUogCCm-XYs8XtZh1sb9q-CY-L07Q9IHGwbI2_-WakH6HXlBxQQtihteGAUdbwJ2hEiWwKxqR8ikaE1azgpaR76EWMl4RQypvmOdpjgkvOGRuhP5ON7gadnO-xb7HGcx-TX0PIpQ3guXZ9MXNXgL8mnQBn6tznn_y2-Bh-6Y3zAbseL3SKH_CkbcGkuDXNO90nHfBZb1y8s_d4HvxFgBizuVhsZ-Kp97Y4z0NSPlm5gLj2vXX9xUv0rNVdhFf39z76Pp18O_lYzL6cnp0czQrDpeBFKY0htWDCsMoQw6woGbSCcN7qipcGqG64AV7ShlkDFpaVNVUta7qsaCNtuY_e7bzr4H8PEJNauWigy-uDH6KitSCSVJUQGX37D3rph9Dn7TJV1bTmsqKZer-jTPAxBmjVOriVDreKErWNS-W41F1cmX1zbxyWK7CP5EM-GTjcAdeug9v_m9R4vHhQFrsOFxPcPHbocKVEXdaV-vH5VH06ZmPGfwo1Lf8CMx2ujw</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Warner, Emily</creator><creator>Krivitsky, Rebecca</creator><creator>Cone, Katherine</creator><creator>Atherton, Phillip</creator><creator>Pitre, Travis</creator><creator>Lanpher, Janell</creator><creator>Giuvelis, Denise</creator><creator>Bergquist, Ivy</creator><creator>King, Tamara</creator><creator>Bilsky, Edward J.</creator><creator>Stevenson, Glenn W.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding</title><author>Warner, Emily ; Krivitsky, Rebecca ; Cone, Katherine ; Atherton, Phillip ; Pitre, Travis ; Lanpher, Janell ; Giuvelis, Denise ; Bergquist, Ivy ; King, Tamara ; Bilsky, Edward J. ; Stevenson, Glenn W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4964-39cc07626c25c0c2d632ef6044fa543ce1a84ce43182dcedeb5dc57971b5189d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Conditioning, Operant - drug effects</topic><topic>Conditioning, Operant - physiology</topic><topic>Diclofenac - pharmacology</topic><topic>Feeding Behavior - drug effects</topic><topic>Feeding Behavior - physiology</topic><topic>Feeding Behavior - psychology</topic><topic>Hindlimb - surgery</topic><topic>Male</topic><topic>Motivation</topic><topic>nociception</topic><topic>Nociception - drug effects</topic><topic>Nociception - physiology</topic><topic>operant conditioning</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - physiopathology</topic><topic>Pain, Postoperative - psychology</topic><topic>pain-depressed behavior</topic><topic>postoperative incisional pain</topic><topic>preclinical pain assay</topic><topic>progressive ratio schedules</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reinforcement Schedule</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warner, Emily</creatorcontrib><creatorcontrib>Krivitsky, Rebecca</creatorcontrib><creatorcontrib>Cone, Katherine</creatorcontrib><creatorcontrib>Atherton, Phillip</creatorcontrib><creatorcontrib>Pitre, Travis</creatorcontrib><creatorcontrib>Lanpher, Janell</creatorcontrib><creatorcontrib>Giuvelis, Denise</creatorcontrib><creatorcontrib>Bergquist, Ivy</creatorcontrib><creatorcontrib>King, Tamara</creatorcontrib><creatorcontrib>Bilsky, Edward J.</creatorcontrib><creatorcontrib>Stevenson, Glenn W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warner, Emily</au><au>Krivitsky, Rebecca</au><au>Cone, Katherine</au><au>Atherton, Phillip</au><au>Pitre, Travis</au><au>Lanpher, Janell</au><au>Giuvelis, Denise</au><au>Bergquist, Ivy</au><au>King, Tamara</au><au>Bilsky, Edward J.</au><au>Stevenson, Glenn W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding</atitle><jtitle>Drug development research</jtitle><addtitle>Drug Dev. Res</addtitle><date>2015-12</date><risdate>2015</risdate><volume>76</volume><issue>8</issue><spage>432</spage><epage>441</epage><pages>432-441</pages><issn>0272-4391</issn><eissn>1098-2299</eissn><coden>DDREDK</coden><abstract>ABSTRACT
Preclinical Research
There has been recent interest in characterizing the effects of pain‐like states on motivated behaviors in order to quantify how pain modulates goal‐directed behavior and the persistence of that behavior. The current set of experiments assessed the effects of an incisional postoperative pain manipulation on food‐maintained responding under a progressive‐ratio (PR) operant schedule. Independent variables included injury state (plantar incision or anesthesia control) and reinforcer type (grain pellet or sugar pellet); dependent variables were tactile sensory thresholds and response breakpoint. Once responding stabilized on the PR schedule, separate groups of rats received a single ventral hind paw incision or anesthesia (control condition). Incision significantly reduced breakpoints in rats responding for grain, but not sugar. In rats responding for sugar, tactile hypersensitivity recovered within 24 hr, indicating a faster recovery of incision‐induced tactile hypersensitivity compared to rats responding for grain, which demonstrated recovery at PD2. The NSAID analgesic, diclofenac (5.6 mg/kg) completely restored incision‐depressed PR operant responding and tactile sensitivity at 3 hr following incision. The PR schedule differentiated between sucrose and grain, suggesting that relative reinforcing efficacy may be an important determinant in detecting pain‐induced changes in motivated behavior. Drug Dev Res 76 : 432–441, 2015. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26494422</pmid><doi>10.1002/ddr.21284</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analgesics - pharmacology Animals Behavior, Animal - drug effects Behavior, Animal - physiology Conditioning, Operant - drug effects Conditioning, Operant - physiology Diclofenac - pharmacology Feeding Behavior - drug effects Feeding Behavior - physiology Feeding Behavior - psychology Hindlimb - surgery Male Motivation nociception Nociception - drug effects Nociception - physiology operant conditioning Pain, Postoperative - drug therapy Pain, Postoperative - physiopathology Pain, Postoperative - psychology pain-depressed behavior postoperative incisional pain preclinical pain assay progressive ratio schedules Rats Rats, Sprague-Dawley Reinforcement Schedule |
| title | Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding |
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