Human T-lymphotropic virus and transfusion safety: does one size fit all?

Human T‐cell leukemia viruses (HTLV‐1 and HTLV‐2) are associated with a variety of human diseases, including some severe ones. Transfusion transmission of HTLV through cellular blood components is undeniable. HTLV screening of blood donations became mandatory in different countries to improve the sa...

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Veröffentlicht in:Transfusion (Philadelphia, Pa.) Pa.), 2016-01, Vol.56 (1), p.249-260
Hauptverfasser: Marano, Giuseppe, Vaglio, Stefania, Pupella, Simonetta, Facco, Giuseppina, Catalano, Liviana, Piccinini, Vanessa, Liumbruno, Giancarlo Maria, Grazzini, Giuliano
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container_end_page 260
container_issue 1
container_start_page 249
container_title Transfusion (Philadelphia, Pa.)
container_volume 56
creator Marano, Giuseppe
Vaglio, Stefania
Pupella, Simonetta
Facco, Giuseppina
Catalano, Liviana
Piccinini, Vanessa
Liumbruno, Giancarlo Maria
Grazzini, Giuliano
description Human T‐cell leukemia viruses (HTLV‐1 and HTLV‐2) are associated with a variety of human diseases, including some severe ones. Transfusion transmission of HTLV through cellular blood components is undeniable. HTLV screening of blood donations became mandatory in different countries to improve the safety of blood supplies. In Japan and Europe, most HTLV‐infected donors are HTLV‐1 positive, whereas in the United States a higher prevalence of HTLV‐2 is reported. Many industrialized countries have also introduced universal leukoreduction of blood components, and pathogen inactivation technologies might be another effective preventive strategy, especially if and when generalized to all blood cellular products. Considering all measures available to minimize HTLV blood transmission, the question is what would be the most suitable and cost‐effective strategy to ensure a high level of blood safety regarding these viruses, considering that there is no solution that can be deemed optimal for all countries.
doi_str_mv 10.1111/trf.13329
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subjects Blood & organ donations
Blood Donors
Blood Safety - economics
Blood Safety - methods
Cost-Benefit Analysis
Europe - epidemiology
Global Health
HTLV-I Infections - diagnosis
HTLV-I Infections - epidemiology
HTLV-I Infections - prevention & control
HTLV-I Infections - transmission
HTLV-II Infections - diagnosis
HTLV-II Infections - epidemiology
HTLV-II Infections - prevention & control
HTLV-II Infections - transmission
Human T-lymphotropic virus 1 - isolation & purification
Human T-lymphotropic virus 2 - isolation & purification
Humans
Prevalence
United States - epidemiology
title Human T-lymphotropic virus and transfusion safety: does one size fit all?
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