Human T-lymphotropic virus and transfusion safety: does one size fit all?
Human T‐cell leukemia viruses (HTLV‐1 and HTLV‐2) are associated with a variety of human diseases, including some severe ones. Transfusion transmission of HTLV through cellular blood components is undeniable. HTLV screening of blood donations became mandatory in different countries to improve the sa...
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Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2016-01, Vol.56 (1), p.249-260 |
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creator | Marano, Giuseppe Vaglio, Stefania Pupella, Simonetta Facco, Giuseppina Catalano, Liviana Piccinini, Vanessa Liumbruno, Giancarlo Maria Grazzini, Giuliano |
description | Human T‐cell leukemia viruses (HTLV‐1 and HTLV‐2) are associated with a variety of human diseases, including some severe ones. Transfusion transmission of HTLV through cellular blood components is undeniable. HTLV screening of blood donations became mandatory in different countries to improve the safety of blood supplies. In Japan and Europe, most HTLV‐infected donors are HTLV‐1 positive, whereas in the United States a higher prevalence of HTLV‐2 is reported. Many industrialized countries have also introduced universal leukoreduction of blood components, and pathogen inactivation technologies might be another effective preventive strategy, especially if and when generalized to all blood cellular products. Considering all measures available to minimize HTLV blood transmission, the question is what would be the most suitable and cost‐effective strategy to ensure a high level of blood safety regarding these viruses, considering that there is no solution that can be deemed optimal for all countries. |
doi_str_mv | 10.1111/trf.13329 |
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Transfusion transmission of HTLV through cellular blood components is undeniable. HTLV screening of blood donations became mandatory in different countries to improve the safety of blood supplies. In Japan and Europe, most HTLV‐infected donors are HTLV‐1 positive, whereas in the United States a higher prevalence of HTLV‐2 is reported. Many industrialized countries have also introduced universal leukoreduction of blood components, and pathogen inactivation technologies might be another effective preventive strategy, especially if and when generalized to all blood cellular products. 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subjects | Blood & organ donations Blood Donors Blood Safety - economics Blood Safety - methods Cost-Benefit Analysis Europe - epidemiology Global Health HTLV-I Infections - diagnosis HTLV-I Infections - epidemiology HTLV-I Infections - prevention & control HTLV-I Infections - transmission HTLV-II Infections - diagnosis HTLV-II Infections - epidemiology HTLV-II Infections - prevention & control HTLV-II Infections - transmission Human T-lymphotropic virus 1 - isolation & purification Human T-lymphotropic virus 2 - isolation & purification Humans Prevalence United States - epidemiology |
title | Human T-lymphotropic virus and transfusion safety: does one size fit all? |
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