Cystatin-C levels in healthy children and adolescents: Influence of age, gender, body mass index and blood pressure
Cystatin-C is considered a more sensitive and specific marker of kidney function than creatinine since it can diagnose patients with earlier-stage of renal dysfunction. The aim of this study is to determine the levels of Cystatin-C in healthy children and adolescents as well as any correlations to a...
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| Veröffentlicht in: | Clinical biochemistry 2016-01, Vol.49 (1-2), p.150-153 |
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| creator | Marmarinos, Antonios Garoufi, Anastasia Panagoulia, Adamantia Dimou, Stamatina Drakatos, Antonis Paraskakis, Irene Gourgiotis, Dimitrios |
| description | Cystatin-C is considered a more sensitive and specific marker of kidney function than creatinine since it can diagnose patients with earlier-stage of renal dysfunction. The aim of this study is to determine the levels of Cystatin-C in healthy children and adolescents as well as any correlations to age, gender, body-mass index (BMI) and blood pressure (BP).
Cystatin-C was measured in 536 healthy Greek children and adolescents (295 males and 241 females) using a nephelometric immunoassay. Additionally, the age, body mass index and blood pressure was recorded for each subject.
Overall, the mean serum Cystatin-C level was 0.79±0.10mg/L. Cystatin-C was found to be statistically significantly lower in females than in males (p |
| doi_str_mv | 10.1016/j.clinbiochem.2015.10.012 |
| format | Article |
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Cystatin-C was measured in 536 healthy Greek children and adolescents (295 males and 241 females) using a nephelometric immunoassay. Additionally, the age, body mass index and blood pressure was recorded for each subject.
Overall, the mean serum Cystatin-C level was 0.79±0.10mg/L. Cystatin-C was found to be statistically significantly lower in females than in males (p<0.001) as well as in prepubertal children compared to adolescents (p<0.001). Higher values of Cystatin-C were observed in subjects with increased BMI (p<0.001). Neither systolic nor diastolic blood pressure was found to significantly affect Cystatin-C levels.
The levels of Cystatin-C were statistically significantly higher in males, compared to age-matched females and also positively correlated with age and BMI.
•Male gender is an independent factor associated to higher levels of Cystatin-C.•Adolescents have higher levels of Cystatin-C than prepubertal children.•Overweightness and obesity are associated with higher Cystatin-C levels.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2015.10.012</identifier><identifier>PMID: 26506118</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Blood Pressure ; Body Mass Index ; Child ; Child, Preschool ; Creatinine ; Cystatin C - blood ; Female ; Humans ; Immunoassay ; Male ; Markers of renal function ; Obesity ; Overweight ; Puberty ; Reference Values</subject><ispartof>Clinical biochemistry, 2016-01, Vol.49 (1-2), p.150-153</ispartof><rights>2015 The Canadian Society of Clinical Chemists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-f2f8ff454ff67dc8e71b68cd6c46210c562f8eb3d307e9f35fb12a8586479d0c3</citedby><cites>FETCH-LOGICAL-c377t-f2f8ff454ff67dc8e71b68cd6c46210c562f8eb3d307e9f35fb12a8586479d0c3</cites><orcidid>0000-0001-7859-6658</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinbiochem.2015.10.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26506118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marmarinos, Antonios</creatorcontrib><creatorcontrib>Garoufi, Anastasia</creatorcontrib><creatorcontrib>Panagoulia, Adamantia</creatorcontrib><creatorcontrib>Dimou, Stamatina</creatorcontrib><creatorcontrib>Drakatos, Antonis</creatorcontrib><creatorcontrib>Paraskakis, Irene</creatorcontrib><creatorcontrib>Gourgiotis, Dimitrios</creatorcontrib><title>Cystatin-C levels in healthy children and adolescents: Influence of age, gender, body mass index and blood pressure</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Cystatin-C is considered a more sensitive and specific marker of kidney function than creatinine since it can diagnose patients with earlier-stage of renal dysfunction. The aim of this study is to determine the levels of Cystatin-C in healthy children and adolescents as well as any correlations to age, gender, body-mass index (BMI) and blood pressure (BP).
Cystatin-C was measured in 536 healthy Greek children and adolescents (295 males and 241 females) using a nephelometric immunoassay. Additionally, the age, body mass index and blood pressure was recorded for each subject.
Overall, the mean serum Cystatin-C level was 0.79±0.10mg/L. Cystatin-C was found to be statistically significantly lower in females than in males (p<0.001) as well as in prepubertal children compared to adolescents (p<0.001). Higher values of Cystatin-C were observed in subjects with increased BMI (p<0.001). Neither systolic nor diastolic blood pressure was found to significantly affect Cystatin-C levels.
The levels of Cystatin-C were statistically significantly higher in males, compared to age-matched females and also positively correlated with age and BMI.
•Male gender is an independent factor associated to higher levels of Cystatin-C.•Adolescents have higher levels of Cystatin-C than prepubertal children.•Overweightness and obesity are associated with higher Cystatin-C levels.</description><subject>Adolescent</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Creatinine</subject><subject>Cystatin C - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Male</subject><subject>Markers of renal function</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Puberty</subject><subject>Reference Values</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyBz49As_kjshBuK-KhUiQucLcced71y7MVOKvbf47AFceRkjed5Z0YPQm8o2VNCxbvj3gQfJ5_MAeY9I7Sr_3tC2RO0o73kDRs4f4p2hJChGSgjV-hFKcdasrYXz9EVEx0RlPY7VMZzWfTiYzPiAA8QCvYRH0CH5XDG5uCDzRCxjhZrmwIUA3Ep7_FtdGGFaAAnh_U93OB7iBbyDZ6SPeNZl22QhZ-_o1NIyeJThlLWDC_RM6dDgVeP7zX6_unjt_FLc_f18-344a4xXMqlccz1zrVd65yQ1vQg6SR6Y4VpBaPEdKICMHHLiYTB8c5NlOm-60UrB0sMv0ZvL3NPOf1YoSxq9vX-EHSEtBZFpSAD4VzIig4X1ORUSganTtnPOp8VJWpzro7qH-dqc761qvOaff24Zp1msH-TfyRXYLwA1S48eMiqGL-5sz6DWZRN_j_W_AKuL5mN</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Marmarinos, Antonios</creator><creator>Garoufi, Anastasia</creator><creator>Panagoulia, Adamantia</creator><creator>Dimou, Stamatina</creator><creator>Drakatos, Antonis</creator><creator>Paraskakis, Irene</creator><creator>Gourgiotis, Dimitrios</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7859-6658</orcidid></search><sort><creationdate>201601</creationdate><title>Cystatin-C levels in healthy children and adolescents: Influence of age, gender, body mass index and blood pressure</title><author>Marmarinos, Antonios ; Garoufi, Anastasia ; Panagoulia, Adamantia ; Dimou, Stamatina ; Drakatos, Antonis ; Paraskakis, Irene ; Gourgiotis, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-f2f8ff454ff67dc8e71b68cd6c46210c562f8eb3d307e9f35fb12a8586479d0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Creatinine</topic><topic>Cystatin C - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Male</topic><topic>Markers of renal function</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Puberty</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marmarinos, Antonios</creatorcontrib><creatorcontrib>Garoufi, Anastasia</creatorcontrib><creatorcontrib>Panagoulia, Adamantia</creatorcontrib><creatorcontrib>Dimou, Stamatina</creatorcontrib><creatorcontrib>Drakatos, Antonis</creatorcontrib><creatorcontrib>Paraskakis, Irene</creatorcontrib><creatorcontrib>Gourgiotis, Dimitrios</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marmarinos, Antonios</au><au>Garoufi, Anastasia</au><au>Panagoulia, Adamantia</au><au>Dimou, Stamatina</au><au>Drakatos, Antonis</au><au>Paraskakis, Irene</au><au>Gourgiotis, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cystatin-C levels in healthy children and adolescents: Influence of age, gender, body mass index and blood pressure</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2016-01</date><risdate>2016</risdate><volume>49</volume><issue>1-2</issue><spage>150</spage><epage>153</epage><pages>150-153</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Cystatin-C is considered a more sensitive and specific marker of kidney function than creatinine since it can diagnose patients with earlier-stage of renal dysfunction. The aim of this study is to determine the levels of Cystatin-C in healthy children and adolescents as well as any correlations to age, gender, body-mass index (BMI) and blood pressure (BP).
Cystatin-C was measured in 536 healthy Greek children and adolescents (295 males and 241 females) using a nephelometric immunoassay. Additionally, the age, body mass index and blood pressure was recorded for each subject.
Overall, the mean serum Cystatin-C level was 0.79±0.10mg/L. Cystatin-C was found to be statistically significantly lower in females than in males (p<0.001) as well as in prepubertal children compared to adolescents (p<0.001). Higher values of Cystatin-C were observed in subjects with increased BMI (p<0.001). Neither systolic nor diastolic blood pressure was found to significantly affect Cystatin-C levels.
The levels of Cystatin-C were statistically significantly higher in males, compared to age-matched females and also positively correlated with age and BMI.
•Male gender is an independent factor associated to higher levels of Cystatin-C.•Adolescents have higher levels of Cystatin-C than prepubertal children.•Overweightness and obesity are associated with higher Cystatin-C levels.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26506118</pmid><doi>10.1016/j.clinbiochem.2015.10.012</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-7859-6658</orcidid></addata></record> |
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| subjects | Adolescent Blood Pressure Body Mass Index Child Child, Preschool Creatinine Cystatin C - blood Female Humans Immunoassay Male Markers of renal function Obesity Overweight Puberty Reference Values |
| title | Cystatin-C levels in healthy children and adolescents: Influence of age, gender, body mass index and blood pressure |
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