Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma
Summary We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the di...
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| Veröffentlicht in: | Human pathology 2016-02, Vol.48, p.167-171 |
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| creator | Furudoï, Adeline Caumont, Charline, MD Dutriaux, Caroline, MD Cappellen, David, PhD Goussot, Jean-François, MD Vergier, Béatrice, MD, PhD Merlio, Christine, MD Barberis, Christophe, MD Merlio, Jean-Philippe, MD, PhD Gros, Audrey, PharmD, PhD |
| description | Summary We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required to differentiate primary MM from colonic metastasis of melanoma, including the absence of past history of other primary melanoma, a unique colonic and abdominal lesion with predominant features of in situ lentiginous MM and a very focal and unique invasive area without other digestive tract or abdominal localization. This tumor displayed a KIT exon 11 mutation leading to a unique combination of p.I571M and p.D572G deleterious amino acid changes. Such pattern also favors the diagnosis as KIT appears as a master oncogenic player in MM oncogenesis. |
| doi_str_mv | 10.1016/j.humpath.2015.09.025 |
| format | Article |
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Such case illustrates the diagnosis criteria required to differentiate primary MM from colonic metastasis of melanoma, including the absence of past history of other primary melanoma, a unique colonic and abdominal lesion with predominant features of in situ lentiginous MM and a very focal and unique invasive area without other digestive tract or abdominal localization. This tumor displayed a KIT exon 11 mutation leading to a unique combination of p.I571M and p.D572G deleterious amino acid changes. Such pattern also favors the diagnosis as KIT appears as a master oncogenic player in MM oncogenesis.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2015.09.025</identifier><identifier>PMID: 26616020</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abdomen ; Adenoma - pathology ; Aged ; Biopsy ; Colon cancer ; Colonic Neoplasms - pathology ; Comorbidity ; Digestive melanoma ; Endoscopy ; Family medical history ; Heart attacks ; Humans ; Hypotheses ; KIT mutation ; Localization ; Male ; Melanoma ; Melanoma - pathology ; Metastasis ; Mutation ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Second Primary - pathology ; Pathology ; Population ; Rodents ; Skin cancer ; Tumors ; Urinary Bladder Neoplasms - epidemiology</subject><ispartof>Human pathology, 2016-02, Vol.48, p.167-171</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-c90cfa41c13f8fe25b12332601088bc1c44f365cf0b4c86f1fb5477f9469980d3</citedby><cites>FETCH-LOGICAL-c518t-c90cfa41c13f8fe25b12332601088bc1c44f365cf0b4c86f1fb5477f9469980d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817715003718$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26616020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furudoï, Adeline</creatorcontrib><creatorcontrib>Caumont, Charline, MD</creatorcontrib><creatorcontrib>Dutriaux, Caroline, MD</creatorcontrib><creatorcontrib>Cappellen, David, PhD</creatorcontrib><creatorcontrib>Goussot, Jean-François, MD</creatorcontrib><creatorcontrib>Vergier, Béatrice, MD, PhD</creatorcontrib><creatorcontrib>Merlio, Christine, MD</creatorcontrib><creatorcontrib>Barberis, Christophe, MD</creatorcontrib><creatorcontrib>Merlio, Jean-Philippe, MD, PhD</creatorcontrib><creatorcontrib>Gros, Audrey, PharmD, PhD</creatorcontrib><title>Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required to differentiate primary MM from colonic metastasis of melanoma, including the absence of past history of other primary melanoma, a unique colonic and abdominal lesion with predominant features of in situ lentiginous MM and a very focal and unique invasive area without other digestive tract or abdominal localization. This tumor displayed a KIT exon 11 mutation leading to a unique combination of p.I571M and p.D572G deleterious amino acid changes. Such pattern also favors the diagnosis as KIT appears as a master oncogenic player in MM oncogenesis.</description><subject>Abdomen</subject><subject>Adenoma - pathology</subject><subject>Aged</subject><subject>Biopsy</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - pathology</subject><subject>Comorbidity</subject><subject>Digestive melanoma</subject><subject>Endoscopy</subject><subject>Family medical history</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>KIT mutation</subject><subject>Localization</subject><subject>Male</subject><subject>Melanoma</subject><subject>Melanoma - pathology</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Pathology</subject><subject>Population</subject><subject>Rodents</subject><subject>Skin cancer</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - epidemiology</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEotvCI4AsceGSMOPETsyBClXlj1QJJOBsOY7d9ZLEi-0U9Rl4aRx2C1IvnObym29mvm-K4hlChYD81a7aLtNepW1FAVkFogLKHhQbZDUtu1rQh8UGoOFlh217UpzGuANAZA17XJxQzpEDhU3x63Nwkwq3ZHDXJiZ3Y8hkRjX7SRE3ExWj104l52fy06UtSUu_jCoQNZiVeU0U0SoaEszeh0TcOC4xhdwwX5O0NVk2i876j4ANfsrqScWUAU20H_2c693AJ8Ujq8Zonh7rWfHt3eXXiw_l1af3Hy_eXpWaYZdKLUBb1aDG2nbWUNYjrWvKAaHreo26aWzNmbbQN7rjFm3Pmra1ouFCdDDUZ8XLg-4--B9LvlpOLmoz5i2MX6LEloMAKjjN6It76M4vYc7bZYpx0dQtx0yxA6WDjzEYK_cHVyWCXNOSO3lMS65pSRAyp5X7nh_Vl34yw9-uu3gycH4ATLbjxpkgo3Zm1mZwwegkB-_-O-LNPQU9umy6Gr-bWxP_XSMjlSC_rC-zfgwygLrFrv4Nlsy_6Q</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Furudoï, Adeline</creator><creator>Caumont, Charline, MD</creator><creator>Dutriaux, Caroline, MD</creator><creator>Cappellen, David, PhD</creator><creator>Goussot, Jean-François, MD</creator><creator>Vergier, Béatrice, MD, PhD</creator><creator>Merlio, Christine, MD</creator><creator>Barberis, Christophe, MD</creator><creator>Merlio, Jean-Philippe, MD, PhD</creator><creator>Gros, Audrey, PharmD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma</title><author>Furudoï, Adeline ; Caumont, Charline, MD ; Dutriaux, Caroline, MD ; Cappellen, David, PhD ; Goussot, Jean-François, MD ; Vergier, Béatrice, MD, PhD ; Merlio, Christine, MD ; Barberis, Christophe, MD ; Merlio, Jean-Philippe, MD, PhD ; Gros, Audrey, PharmD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-c90cfa41c13f8fe25b12332601088bc1c44f365cf0b4c86f1fb5477f9469980d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abdomen</topic><topic>Adenoma - pathology</topic><topic>Aged</topic><topic>Biopsy</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - pathology</topic><topic>Comorbidity</topic><topic>Digestive melanoma</topic><topic>Endoscopy</topic><topic>Family medical history</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>KIT mutation</topic><topic>Localization</topic><topic>Male</topic><topic>Melanoma</topic><topic>Melanoma - pathology</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Pathology</topic><topic>Population</topic><topic>Rodents</topic><topic>Skin cancer</topic><topic>Tumors</topic><topic>Urinary Bladder Neoplasms - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furudoï, Adeline</creatorcontrib><creatorcontrib>Caumont, Charline, MD</creatorcontrib><creatorcontrib>Dutriaux, Caroline, MD</creatorcontrib><creatorcontrib>Cappellen, David, PhD</creatorcontrib><creatorcontrib>Goussot, Jean-François, MD</creatorcontrib><creatorcontrib>Vergier, Béatrice, MD, PhD</creatorcontrib><creatorcontrib>Merlio, Christine, MD</creatorcontrib><creatorcontrib>Barberis, Christophe, MD</creatorcontrib><creatorcontrib>Merlio, Jean-Philippe, MD, PhD</creatorcontrib><creatorcontrib>Gros, Audrey, PharmD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furudoï, Adeline</au><au>Caumont, Charline, MD</au><au>Dutriaux, Caroline, MD</au><au>Cappellen, David, PhD</au><au>Goussot, Jean-François, MD</au><au>Vergier, Béatrice, MD, PhD</au><au>Merlio, Christine, MD</au><au>Barberis, Christophe, MD</au><au>Merlio, Jean-Philippe, MD, PhD</au><au>Gros, Audrey, PharmD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>48</volume><spage>167</spage><epage>171</epage><pages>167-171</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><abstract>Summary We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required to differentiate primary MM from colonic metastasis of melanoma, including the absence of past history of other primary melanoma, a unique colonic and abdominal lesion with predominant features of in situ lentiginous MM and a very focal and unique invasive area without other digestive tract or abdominal localization. This tumor displayed a KIT exon 11 mutation leading to a unique combination of p.I571M and p.D572G deleterious amino acid changes. Such pattern also favors the diagnosis as KIT appears as a master oncogenic player in MM oncogenesis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26616020</pmid><doi>10.1016/j.humpath.2015.09.025</doi><tpages>5</tpages></addata></record> |
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| subjects | Abdomen Adenoma - pathology Aged Biopsy Colon cancer Colonic Neoplasms - pathology Comorbidity Digestive melanoma Endoscopy Family medical history Heart attacks Humans Hypotheses KIT mutation Localization Male Melanoma Melanoma - pathology Metastasis Mutation Neoplasms, Multiple Primary - pathology Neoplasms, Second Primary - pathology Pathology Population Rodents Skin cancer Tumors Urinary Bladder Neoplasms - epidemiology |
| title | Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma |
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