A novel esterase subfamily with α/β‐hydrolase fold suggested by structures of two bacterial enzymes homologous to l‐homoserine O‐acetyl transferases

MekB from Pseudomonas veronii and CgHle from Corynebacteriumglutamicum belong to the superfamily of α/β‐hydrolase fold proteins. Based on sequence comparisons, they are annotated as homoserine transacetylases in popular databases like UNIPROT, PFAM or ESTHER. However, experimentally, MekB and CgHle...

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Veröffentlicht in:	FEBS letters 2016-01, Vol.590 (1), p.174-184
Hauptverfasser:	Tölzer, Christine, Pal, Sonia, Watzlawick, Hildegard, Altenbuchner, Josef, Niefind, Karsten, Ferguson, Stuart
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl Coenzyme A - chemistry Acetyl Coenzyme A - metabolism acetyl ester hydrolysis Acetyltransferases - chemistry Acetyltransferases - classification Acetyltransferases - metabolism Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites Catalytic Domain Conserved Sequence crystal structure Crystallography, X-Ray Databases, Protein esterase Esterases - chemistry Esterases - metabolism Homoserine - chemistry Homoserine - metabolism l‐homoserine O‐transacetylase methyl alkyl ketone degradation pathway Models, Molecular Molecular Sequence Data Protein Conformation Protein Folding Protein Structure, Secondary Pseudomonas - enzymology Sequence Alignment Sequence Homology, Amino Acid Structural Homology, Protein Substrate Specificity α/β‐hydrolase fold
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