Tn551-mediated insertional inactivation of the fmtB gene encoding a cell wall-associated protein abolishes methicillin resistance in Staphylococcus aureus

A Tn551 insert in a gene termed fmtB was shown to reduce oxacillin as well as Triton X-100 resistance in highly methicillin-resistant Staphylococcus aureus (MRSA) COL. Backcrosses of fmtB::Tn551 into S. aureus COL and into two genetically distinct MRSA strains, KSA8 and NCTC10443, confirmed the link...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2000-04, Vol.45 (4), p.421-431
Hauptverfasser:	Komatsuzawa, Hitoshi, Ohta, Kouji, Sugai, Motoyuki, Fujiwara, Tamaki, Glanzmann, Philipp, Berger-Bächi, Brigitte, Suginaka, Hidekazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Biological and medical sciences Blotting, Western Cell Wall - metabolism Cloning, Molecular DNA Primers DNA Transposable Elements - genetics DNA, Bacterial - genetics fmtB gene Genes, Bacterial - genetics Genetic Complementation Test glucosamine-1-phosphate Indicators and Reagents Medical sciences methicillin Methicillin Resistance - genetics Microbial Sensitivity Tests Molecular Sequence Data Mutagenesis - genetics Oxacillin - pharmacology Pharmacology. Drug treatments Retroelements - genetics Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Staphylococcus aureus - metabolism Transduction, Genetic transposon Tn551
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