Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models

Aims/hypothesis ‘Glucotoxicity’ is a term used to convey the negative effect of hyperglycaemia on beta cell function; however, the underlying molecular mechanisms that impair insulin secretion and gene expression are poorly defined. Our objective was to define the role of transcription factor v-ets...

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Veröffentlicht in:	Diabetologia 2016-02, Vol.59 (2), p.316-324
Hauptverfasser:	Chen, Fang, Sha, Min, Wang, Yanyang, Wu, Tijun, Shan, Wei, Liu, Jia, Zhou, Wenbo, Zhu, Yunxia, Sun, Yujie, Shi, Yuguang, Bleich, David, Han, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Blood Glucose - physiology Cells, Cultured Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Gene expression Gene Expression Regulation Glucose Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human Physiology Hyperglycemia Hyperglycemia - blood Hyperglycemia - genetics Hyperglycemia - physiopathology Hypotheses Insulin Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Mice, Transgenic Proto-Oncogene Protein c-ets-1 - physiology Rats Rats, Sprague-Dawley Rodents Trans-Activators - genetics Trans-Activators - metabolism Transcription factors Transgenic animals
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