A novel triazole derivative of betulinic acid induces extrinsic and intrinsic apoptosis in human leukemia HL-60 cells

In an attempt to arrive at more potent cytotoxic agent than the bioactive natural product betulinic acid, influence of small structural modifications of its 1, 2, 3 triazole derivatives tethered at C-28 and both C3, C-28 using click chemistry approach has been studied. The chemically characterized t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2016-01, Vol.108, p.104-116
Hauptverfasser:	Khan, Imran, Guru, Santosh K., Rath, Santosh K., Chinthakindi, Praveen K., Singh, Buddh, Koul, Surrinder, Bhushan, Shashi, Sangwan, Payare L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Betulinic acid Cell Proliferation - drug effects Click chemistry Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HL-60 Cells Human leukemia Humans Leukemia - pathology Molecular Structure Structure-Activity Relationship Triazole derivative Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacology Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!