Myopathy in a patient with systemic AA amyloidosis possibly induced by psoriasis vulgaris: An autopsy case
ABSTRACT Introduction: Amyloid myopathy is a rare manifestation of primary systemic amyloid light‐chain (AL) amyloidosis, but it has not been reported to occur in secondary amyloid A (AA) amyloidosis. Methods: We describe a 46‐year‐old man with psoriasis vulgaris who presented with idiopathic upper...
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| Veröffentlicht in: | Muscle & nerve 2015-12, Vol.52 (6), p.1113-1117 |
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| creator | Tanabe, Hajime Maki, Yoshimitsu Urabe, Shogo Higuchi, Itsuro Obayashi, Konen Hokezu, Youichi |
| description | ABSTRACT
Introduction: Amyloid myopathy is a rare manifestation of primary systemic amyloid light‐chain (AL) amyloidosis, but it has not been reported to occur in secondary amyloid A (AA) amyloidosis. Methods: We describe a 46‐year‐old man with psoriasis vulgaris who presented with idiopathic upper and lower limb weakness and was eventually diagnosed with hypertrophic cardiomyopathy. Muscle biopsy findings were compatible with mild inflammatory myopathy. He died of cardiopulmonary arrest, and an autopsy was performed. Results: The autopsy revealed amyloid plaques immunopositive for AA (but not AL or transthyretin) in the perimysial, perivascular, and endomysial regions of the iliopsoas muscle. The final diagnosis was systemic AA amyloidosis with muscle amyloid angiopathy, possibly induced by psoriasis vulgaris. Conclusion: This is an extremely rare autopsy case of myopathy in a patient with systemic AA amyloidosis. The reason for the unusually large amount of amyloid deposition in muscle blood vessel walls remains unclear. Muscle Nerve 52: 1113–1117, 2015 |
| doi_str_mv | 10.1002/mus.24771 |
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Introduction: Amyloid myopathy is a rare manifestation of primary systemic amyloid light‐chain (AL) amyloidosis, but it has not been reported to occur in secondary amyloid A (AA) amyloidosis. Methods: We describe a 46‐year‐old man with psoriasis vulgaris who presented with idiopathic upper and lower limb weakness and was eventually diagnosed with hypertrophic cardiomyopathy. Muscle biopsy findings were compatible with mild inflammatory myopathy. He died of cardiopulmonary arrest, and an autopsy was performed. Results: The autopsy revealed amyloid plaques immunopositive for AA (but not AL or transthyretin) in the perimysial, perivascular, and endomysial regions of the iliopsoas muscle. The final diagnosis was systemic AA amyloidosis with muscle amyloid angiopathy, possibly induced by psoriasis vulgaris. Conclusion: This is an extremely rare autopsy case of myopathy in a patient with systemic AA amyloidosis. The reason for the unusually large amount of amyloid deposition in muscle blood vessel walls remains unclear. Muscle Nerve 52: 1113–1117, 2015</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.24771</identifier><identifier>PMID: 26179325</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>AA amyloidosis ; Amyloidosis - etiology ; Amyloidosis - parasitology ; Autopsy ; Humans ; hypertrophic cardiomyopathy ; Immunoglobulin Light-chain Amyloidosis ; Male ; Middle Aged ; muscle amyloid angiopathy ; Muscle Fibers, Skeletal - pathology ; Muscular Diseases - etiology ; Muscular Diseases - parasitology ; Prealbumin - metabolism ; Psoriasis - complications ; psoriasis vulgaris ; serum amyloid A ; Serum Amyloid A Protein - metabolism</subject><ispartof>Muscle & nerve, 2015-12, Vol.52 (6), p.1113-1117</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4331-7a3d5ccb277625de0cc5567ddcb8a646a7ec79054c2762b74d7fc961462e8b1a3</citedby><cites>FETCH-LOGICAL-c4331-7a3d5ccb277625de0cc5567ddcb8a646a7ec79054c2762b74d7fc961462e8b1a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.24771$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.24771$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26179325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanabe, Hajime</creatorcontrib><creatorcontrib>Maki, Yoshimitsu</creatorcontrib><creatorcontrib>Urabe, Shogo</creatorcontrib><creatorcontrib>Higuchi, Itsuro</creatorcontrib><creatorcontrib>Obayashi, Konen</creatorcontrib><creatorcontrib>Hokezu, Youichi</creatorcontrib><title>Myopathy in a patient with systemic AA amyloidosis possibly induced by psoriasis vulgaris: An autopsy case</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>ABSTRACT
Introduction: Amyloid myopathy is a rare manifestation of primary systemic amyloid light‐chain (AL) amyloidosis, but it has not been reported to occur in secondary amyloid A (AA) amyloidosis. Methods: We describe a 46‐year‐old man with psoriasis vulgaris who presented with idiopathic upper and lower limb weakness and was eventually diagnosed with hypertrophic cardiomyopathy. Muscle biopsy findings were compatible with mild inflammatory myopathy. He died of cardiopulmonary arrest, and an autopsy was performed. Results: The autopsy revealed amyloid plaques immunopositive for AA (but not AL or transthyretin) in the perimysial, perivascular, and endomysial regions of the iliopsoas muscle. The final diagnosis was systemic AA amyloidosis with muscle amyloid angiopathy, possibly induced by psoriasis vulgaris. Conclusion: This is an extremely rare autopsy case of myopathy in a patient with systemic AA amyloidosis. The reason for the unusually large amount of amyloid deposition in muscle blood vessel walls remains unclear. Muscle Nerve 52: 1113–1117, 2015</description><subject>AA amyloidosis</subject><subject>Amyloidosis - etiology</subject><subject>Amyloidosis - parasitology</subject><subject>Autopsy</subject><subject>Humans</subject><subject>hypertrophic cardiomyopathy</subject><subject>Immunoglobulin Light-chain Amyloidosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>muscle amyloid angiopathy</subject><subject>Muscle Fibers, Skeletal - pathology</subject><subject>Muscular Diseases - etiology</subject><subject>Muscular Diseases - parasitology</subject><subject>Prealbumin - metabolism</subject><subject>Psoriasis - complications</subject><subject>psoriasis vulgaris</subject><subject>serum amyloid A</subject><subject>Serum Amyloid A Protein - metabolism</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwyAch4nR6Jwe_AKGox46oS3QelsWN02cJr7HC6HAFG3X2n_r7LeXOefNEyQ8vyfhQeiAkgElJDwpWhiEsRB0A_UoSUUQszTZRD1C4yTgUfq0g3YB3gghNOFiG-2EnIo0ClkPvU27slLNa4fdHCvsr87OG7xwzSuGDhpbOI2HQ6yKLi-dKcEBrkoAl-XLiWm1NTjrcAVl7dTy9bPNX1Tt4BQPvbFtygo6rBXYPbQ1UznY_d-zj-7HZ3ej8-DyenIxGl4GOo4iGggVGaZ1FgrBQ2Ys0ZoxLozRWaJ4zJWwWqSExTr0QCZiI2Y65TTmoU0yqqI-Olp5q7r8aC00snCgbZ6ruS1bkFRwkqQ8JcSjxytU1_5PtZ3JqnaFqjtJiVymlT6t_Enr2cNfbZsV1vyR65YeOFkBC5fb7n-TnN7frpXBauF86K-_harfJReRYPLxaiLpZPx8wx-oZNE3-XiToA</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Tanabe, Hajime</creator><creator>Maki, Yoshimitsu</creator><creator>Urabe, Shogo</creator><creator>Higuchi, Itsuro</creator><creator>Obayashi, Konen</creator><creator>Hokezu, Youichi</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Myopathy in a patient with systemic AA amyloidosis possibly induced by psoriasis vulgaris: An autopsy case</title><author>Tanabe, Hajime ; Maki, Yoshimitsu ; Urabe, Shogo ; Higuchi, Itsuro ; Obayashi, Konen ; Hokezu, Youichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4331-7a3d5ccb277625de0cc5567ddcb8a646a7ec79054c2762b74d7fc961462e8b1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>AA amyloidosis</topic><topic>Amyloidosis - etiology</topic><topic>Amyloidosis - parasitology</topic><topic>Autopsy</topic><topic>Humans</topic><topic>hypertrophic cardiomyopathy</topic><topic>Immunoglobulin Light-chain Amyloidosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>muscle amyloid angiopathy</topic><topic>Muscle Fibers, Skeletal - pathology</topic><topic>Muscular Diseases - etiology</topic><topic>Muscular Diseases - parasitology</topic><topic>Prealbumin - metabolism</topic><topic>Psoriasis - complications</topic><topic>psoriasis vulgaris</topic><topic>serum amyloid A</topic><topic>Serum Amyloid A Protein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanabe, Hajime</creatorcontrib><creatorcontrib>Maki, Yoshimitsu</creatorcontrib><creatorcontrib>Urabe, Shogo</creatorcontrib><creatorcontrib>Higuchi, Itsuro</creatorcontrib><creatorcontrib>Obayashi, Konen</creatorcontrib><creatorcontrib>Hokezu, Youichi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanabe, Hajime</au><au>Maki, Yoshimitsu</au><au>Urabe, Shogo</au><au>Higuchi, Itsuro</au><au>Obayashi, Konen</au><au>Hokezu, Youichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myopathy in a patient with systemic AA amyloidosis possibly induced by psoriasis vulgaris: An autopsy case</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2015-12</date><risdate>2015</risdate><volume>52</volume><issue>6</issue><spage>1113</spage><epage>1117</epage><pages>1113-1117</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>ABSTRACT
Introduction: Amyloid myopathy is a rare manifestation of primary systemic amyloid light‐chain (AL) amyloidosis, but it has not been reported to occur in secondary amyloid A (AA) amyloidosis. Methods: We describe a 46‐year‐old man with psoriasis vulgaris who presented with idiopathic upper and lower limb weakness and was eventually diagnosed with hypertrophic cardiomyopathy. Muscle biopsy findings were compatible with mild inflammatory myopathy. He died of cardiopulmonary arrest, and an autopsy was performed. Results: The autopsy revealed amyloid plaques immunopositive for AA (but not AL or transthyretin) in the perimysial, perivascular, and endomysial regions of the iliopsoas muscle. The final diagnosis was systemic AA amyloidosis with muscle amyloid angiopathy, possibly induced by psoriasis vulgaris. Conclusion: This is an extremely rare autopsy case of myopathy in a patient with systemic AA amyloidosis. The reason for the unusually large amount of amyloid deposition in muscle blood vessel walls remains unclear. Muscle Nerve 52: 1113–1117, 2015</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26179325</pmid><doi>10.1002/mus.24771</doi><tpages>5</tpages></addata></record> |
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| subjects | AA amyloidosis Amyloidosis - etiology Amyloidosis - parasitology Autopsy Humans hypertrophic cardiomyopathy Immunoglobulin Light-chain Amyloidosis Male Middle Aged muscle amyloid angiopathy Muscle Fibers, Skeletal - pathology Muscular Diseases - etiology Muscular Diseases - parasitology Prealbumin - metabolism Psoriasis - complications psoriasis vulgaris serum amyloid A Serum Amyloid A Protein - metabolism |
| title | Myopathy in a patient with systemic AA amyloidosis possibly induced by psoriasis vulgaris: An autopsy case |
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