Circulating hepcidin in type 2 diabetes: A multivariate analysis and double blind evaluation of metformin effects
SCOPE: Very few studies have evaluated serum hepcidin in patients with type 2 diabetes and they have reported conflicting results. In addition, the effect of antidiabetic drugs on circulating hepcidin has not been explored so far. The aims of the study were to evaluate hepcidin concentrations and he...
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| Veröffentlicht in: | Molecular nutrition & food research 2015-12, Vol.59 (12), p.2460-2470 |
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| creator | Suárez‐Ortegón, Milton Fabián Moreno, María Arbeláez, Alejandra Xifra, Gemma Mosquera, Mildrey Moreno‐Navarrete, José María Aguilar‐de Plata, Cecilia Esteve, Eduardo Ricart, Wifredo Fernández‐Real, José Manuel |
| description | SCOPE: Very few studies have evaluated serum hepcidin in patients with type 2 diabetes and they have reported conflicting results. In addition, the effect of antidiabetic drugs on circulating hepcidin has not been explored so far. The aims of the study were to evaluate hepcidin concentrations and hepcidin/ferritin ratio in type 2 diabetes subjects and healthy non‐diabetic controls and to evaluate the effect of metformin on hepcidin concentrations. METHODS AND RESULTS: Study 1: Cross‐sectional multivariate study of 239 non‐diabetic individuals and 65 people with type 2 diabetes. The multivariate analysis included covariates of chronic inflammation, BMI, pharmacological treatment, menopausal status and insulin resistance. Study 2: Randomized, double‐blinded, placebo‐controlled 4‐month trial metformin compared to placebo among 36 type 2 diabetic patients. In both groups diet was controlled by maintaining a hypocaloric intake across the trial. Hepcidin levels were significantly lower in patients with type 2 diabetes than in non‐diabetic individuals either in crude or adjusted regression models (P |
| doi_str_mv | 10.1002/mnfr.201500310 |
| format | Article |
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In addition, the effect of antidiabetic drugs on circulating hepcidin has not been explored so far. The aims of the study were to evaluate hepcidin concentrations and hepcidin/ferritin ratio in type 2 diabetes subjects and healthy non‐diabetic controls and to evaluate the effect of metformin on hepcidin concentrations. METHODS AND RESULTS: Study 1: Cross‐sectional multivariate study of 239 non‐diabetic individuals and 65 people with type 2 diabetes. The multivariate analysis included covariates of chronic inflammation, BMI, pharmacological treatment, menopausal status and insulin resistance. Study 2: Randomized, double‐blinded, placebo‐controlled 4‐month trial metformin compared to placebo among 36 type 2 diabetic patients. In both groups diet was controlled by maintaining a hypocaloric intake across the trial. Hepcidin levels were significantly lower in patients with type 2 diabetes than in non‐diabetic individuals either in crude or adjusted regression models (P<0.05). Hepcidin decreased in both arms of the trial (Placebo, p = 0.004; metformin, p = 0.022). CONCLUSION: Circulating hepcidin was significantly and independently lower in type 2 diabetes. Metformin treatment is not associated with reductions in hepcidin but hypocaloric diet could be involved.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201500310</identifier><identifier>PMID: 26394887</identifier><language>eng</language><publisher>Germany: Wiley-VCH</publisher><subject>Adult ; blood serum ; body mass index ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Double-Blind Method ; Female ; ferritin ; Ferritins - blood ; glycemic effect ; Hepcidin ; Hepcidin/ferritin ratio ; Hepcidins - blood ; Humans ; Hypoglycemic Agents - therapeutic use ; inflammation ; Insulin Resistance ; low calorie diet ; Male ; menopause ; Metformin ; Metformin - therapeutic use ; Middle Aged ; Multivariate Analysis ; noninsulin-dependent diabetes mellitus ; patients ; people ; placebos ; regression analysis ; Type 2 diabetes</subject><ispartof>Molecular nutrition & food research, 2015-12, Vol.59 (12), p.2460-2470</ispartof><rights>2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4729-c31fe749d3cf419556059efda22511d859663fab3b6906b3cdef9f479516300f3</citedby><cites>FETCH-LOGICAL-c4729-c31fe749d3cf419556059efda22511d859663fab3b6906b3cdef9f479516300f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201500310$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201500310$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26394887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suárez‐Ortegón, Milton Fabián</creatorcontrib><creatorcontrib>Moreno, María</creatorcontrib><creatorcontrib>Arbeláez, Alejandra</creatorcontrib><creatorcontrib>Xifra, Gemma</creatorcontrib><creatorcontrib>Mosquera, Mildrey</creatorcontrib><creatorcontrib>Moreno‐Navarrete, José María</creatorcontrib><creatorcontrib>Aguilar‐de Plata, Cecilia</creatorcontrib><creatorcontrib>Esteve, Eduardo</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Fernández‐Real, José Manuel</creatorcontrib><title>Circulating hepcidin in type 2 diabetes: A multivariate analysis and double blind evaluation of metformin effects</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>SCOPE: Very few studies have evaluated serum hepcidin in patients with type 2 diabetes and they have reported conflicting results. In addition, the effect of antidiabetic drugs on circulating hepcidin has not been explored so far. The aims of the study were to evaluate hepcidin concentrations and hepcidin/ferritin ratio in type 2 diabetes subjects and healthy non‐diabetic controls and to evaluate the effect of metformin on hepcidin concentrations. METHODS AND RESULTS: Study 1: Cross‐sectional multivariate study of 239 non‐diabetic individuals and 65 people with type 2 diabetes. The multivariate analysis included covariates of chronic inflammation, BMI, pharmacological treatment, menopausal status and insulin resistance. Study 2: Randomized, double‐blinded, placebo‐controlled 4‐month trial metformin compared to placebo among 36 type 2 diabetic patients. In both groups diet was controlled by maintaining a hypocaloric intake across the trial. Hepcidin levels were significantly lower in patients with type 2 diabetes than in non‐diabetic individuals either in crude or adjusted regression models (P<0.05). Hepcidin decreased in both arms of the trial (Placebo, p = 0.004; metformin, p = 0.022). CONCLUSION: Circulating hepcidin was significantly and independently lower in type 2 diabetes. Metformin treatment is not associated with reductions in hepcidin but hypocaloric diet could be involved.</description><subject>Adult</subject><subject>blood serum</subject><subject>body mass index</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>ferritin</subject><subject>Ferritins - blood</subject><subject>glycemic effect</subject><subject>Hepcidin</subject><subject>Hepcidin/ferritin ratio</subject><subject>Hepcidins - blood</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>inflammation</subject><subject>Insulin Resistance</subject><subject>low calorie diet</subject><subject>Male</subject><subject>menopause</subject><subject>Metformin</subject><subject>Metformin - therapeutic use</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>patients</subject><subject>people</subject><subject>placebos</subject><subject>regression analysis</subject><subject>Type 2 diabetes</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFv1DAQRiMEoqVw5Qg-cskytmMn5lat2lKpLQhakLhYTjwuBifZ2klh_329Stkr0kgzI73vHb6ieE1hRQHY-35wccWACgBO4UlxSCXlZUU5f7q_mTgoXqT0a4ewij8vDpjkqmqa-rC4W_vYzcFMfrglP3HTeesHkmfabpAwYr1pccL0gRyTfg6TvzfRmwmJGUzYJp_yYYkd5zYgaYPPD96bMGfhOJDRkR4nN8Y-G9E57Kb0snjmTEj46nEfFTenJ9frj-XFp7Pz9fFF2VU1U2XHqcO6UpZ3rqJKCAlCobOGMUGpbYSSkjvT8lYqkC3vLDrlqloJKjmA40fFu8W7iePdjGnSvU8dhmAGHOekaS2hUZwBz-hqQbs4phTR6U30vYlbTUHvata7mvW-5hx48-ie2x7tHv_XawaqBfjjA27_o9OXV6dfWKVUjpVLzKcJ_-5jJv7Wsua10N-vznQjKFx_-_FZX2b-7cI7M2pzG33SN1-zVwJAU0Mj-APoVaGm</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Suárez‐Ortegón, Milton Fabián</creator><creator>Moreno, María</creator><creator>Arbeláez, Alejandra</creator><creator>Xifra, Gemma</creator><creator>Mosquera, Mildrey</creator><creator>Moreno‐Navarrete, José María</creator><creator>Aguilar‐de Plata, Cecilia</creator><creator>Esteve, Eduardo</creator><creator>Ricart, Wifredo</creator><creator>Fernández‐Real, José Manuel</creator><general>Wiley-VCH</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Circulating hepcidin in type 2 diabetes: A multivariate analysis and double blind evaluation of metformin effects</title><author>Suárez‐Ortegón, Milton Fabián ; Moreno, María ; Arbeláez, Alejandra ; Xifra, Gemma ; Mosquera, Mildrey ; Moreno‐Navarrete, José María ; Aguilar‐de Plata, Cecilia ; Esteve, Eduardo ; Ricart, Wifredo ; Fernández‐Real, José Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4729-c31fe749d3cf419556059efda22511d859663fab3b6906b3cdef9f479516300f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>blood serum</topic><topic>body mass index</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>ferritin</topic><topic>Ferritins - blood</topic><topic>glycemic effect</topic><topic>Hepcidin</topic><topic>Hepcidin/ferritin ratio</topic><topic>Hepcidins - blood</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>inflammation</topic><topic>Insulin Resistance</topic><topic>low calorie diet</topic><topic>Male</topic><topic>menopause</topic><topic>Metformin</topic><topic>Metformin - therapeutic use</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>patients</topic><topic>people</topic><topic>placebos</topic><topic>regression analysis</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suárez‐Ortegón, Milton Fabián</creatorcontrib><creatorcontrib>Moreno, María</creatorcontrib><creatorcontrib>Arbeláez, Alejandra</creatorcontrib><creatorcontrib>Xifra, Gemma</creatorcontrib><creatorcontrib>Mosquera, Mildrey</creatorcontrib><creatorcontrib>Moreno‐Navarrete, José María</creatorcontrib><creatorcontrib>Aguilar‐de Plata, Cecilia</creatorcontrib><creatorcontrib>Esteve, Eduardo</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Fernández‐Real, José Manuel</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suárez‐Ortegón, Milton Fabián</au><au>Moreno, María</au><au>Arbeláez, Alejandra</au><au>Xifra, Gemma</au><au>Mosquera, Mildrey</au><au>Moreno‐Navarrete, José María</au><au>Aguilar‐de Plata, Cecilia</au><au>Esteve, Eduardo</au><au>Ricart, Wifredo</au><au>Fernández‐Real, José Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating hepcidin in type 2 diabetes: A multivariate analysis and double blind evaluation of metformin effects</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol. Nutr. Food Res</addtitle><date>2015-12</date><risdate>2015</risdate><volume>59</volume><issue>12</issue><spage>2460</spage><epage>2470</epage><pages>2460-2470</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>SCOPE: Very few studies have evaluated serum hepcidin in patients with type 2 diabetes and they have reported conflicting results. In addition, the effect of antidiabetic drugs on circulating hepcidin has not been explored so far. The aims of the study were to evaluate hepcidin concentrations and hepcidin/ferritin ratio in type 2 diabetes subjects and healthy non‐diabetic controls and to evaluate the effect of metformin on hepcidin concentrations. METHODS AND RESULTS: Study 1: Cross‐sectional multivariate study of 239 non‐diabetic individuals and 65 people with type 2 diabetes. The multivariate analysis included covariates of chronic inflammation, BMI, pharmacological treatment, menopausal status and insulin resistance. Study 2: Randomized, double‐blinded, placebo‐controlled 4‐month trial metformin compared to placebo among 36 type 2 diabetic patients. In both groups diet was controlled by maintaining a hypocaloric intake across the trial. Hepcidin levels were significantly lower in patients with type 2 diabetes than in non‐diabetic individuals either in crude or adjusted regression models (P<0.05). Hepcidin decreased in both arms of the trial (Placebo, p = 0.004; metformin, p = 0.022). CONCLUSION: Circulating hepcidin was significantly and independently lower in type 2 diabetes. Metformin treatment is not associated with reductions in hepcidin but hypocaloric diet could be involved.</abstract><cop>Germany</cop><pub>Wiley-VCH</pub><pmid>26394887</pmid><doi>10.1002/mnfr.201500310</doi><tpages>11</tpages></addata></record> |
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| ispartof | Molecular nutrition & food research, 2015-12, Vol.59 (12), p.2460-2470 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult blood serum body mass index Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Double-Blind Method Female ferritin Ferritins - blood glycemic effect Hepcidin Hepcidin/ferritin ratio Hepcidins - blood Humans Hypoglycemic Agents - therapeutic use inflammation Insulin Resistance low calorie diet Male menopause Metformin Metformin - therapeutic use Middle Aged Multivariate Analysis noninsulin-dependent diabetes mellitus patients people placebos regression analysis Type 2 diabetes |
| title | Circulating hepcidin in type 2 diabetes: A multivariate analysis and double blind evaluation of metformin effects |
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