Sleeve gastrectomy improves obstructive sleep apnea syndrome (OSAS): 5 year longitudinal study
Abstract Background Obstructive sleep apnea syndrome (OSAS) is prevalent among morbidly obese patients. Evaluation of the specific effects of sleeve gastrectomy (SG) on upper airway function has not been reported. Given the possibility that some patients will not respond despite weight loss, no stud...
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| creator | del Genio, Gianmattia, M.D., Ph.D., F.A.C.S Limongelli, Paolo, M.D., Ph.D del Genio, Federica, M.D., Ph.D Motta, Gaetano, M.D Docimo, Ludovico, M.D., Ph.D Testa, Domenico, M.D |
| description | Abstract Background Obstructive sleep apnea syndrome (OSAS) is prevalent among morbidly obese patients. Evaluation of the specific effects of sleeve gastrectomy (SG) on upper airway function has not been reported. Given the possibility that some patients will not respond despite weight loss, no studies have investigated whether other mechanisms may be responsible for persistent OSAS after bariatric surgery. Objectives To evaluate by subjective and objective assessment the impact of SG on upper respiratory physiology in the long-term. Setting University Hospital, Division of Bariatric and ENT Surgery, in Italy. Methods Thirty-six consecutive patients with OSAS who underwent laparoscopic SG were prospectively enrolled. The effect of SG on respiratory function and OSAS was followed for 5 years. Results All patients completed the 5-year follow-up. A significant ( P |
| doi_str_mv | 10.1016/j.soard.2015.02.020 |
| format | Article |
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Evaluation of the specific effects of sleeve gastrectomy (SG) on upper airway function has not been reported. Given the possibility that some patients will not respond despite weight loss, no studies have investigated whether other mechanisms may be responsible for persistent OSAS after bariatric surgery. Objectives To evaluate by subjective and objective assessment the impact of SG on upper respiratory physiology in the long-term. Setting University Hospital, Division of Bariatric and ENT Surgery, in Italy. Methods Thirty-six consecutive patients with OSAS who underwent laparoscopic SG were prospectively enrolled. The effect of SG on respiratory function and OSAS was followed for 5 years. Results All patients completed the 5-year follow-up. A significant ( P <.001) improvement in modified Epworth Sleepiness Scale questionnaire (ESS) was obtained in 91.6% (33/36) of patients. The Apnea/Hypopnea index (AHI) improved in 80.6% (29/36) of patients after surgery (from 32.8±1.7 to 5.8±1.2 ( P <.001), 4.9±1.7). The remaining 19.4% (7/36) of patients with a positive ESS and/or AHI all had an associated respiratory resistance due to nasal obstructive diseases. Conclusion SG improved OSAS overall, but patients who did not improve or only partially improved despite weight loss were found to have an associated nasal responsible pathology. How these patients will respond to nasal surgery and whether a 2-step procedure should be recommended for OSAS patients requires further study.</description><identifier>ISSN: 1550-7289</identifier><identifier>EISSN: 1878-7533</identifier><identifier>DOI: 10.1016/j.soard.2015.02.020</identifier><identifier>PMID: 25862184</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Bariatric surgery ; Disease Progression ; ENT ; Female ; Follow-Up Studies ; Gastrectomy - methods ; Gastroenterology and Hepatology ; Humans ; Italy - epidemiology ; Male ; Middle Aged ; Obesity, Morbid - complications ; Obesity, Morbid - surgery ; OSAS ; Polysomnography ; Prevalence ; Prospective Studies ; Severity of Illness Index ; Sleep Apnea, Obstructive - epidemiology ; Sleep Apnea, Obstructive - etiology ; Sleep Apnea, Obstructive - physiopathology ; Sleeve gastrectomy ; Surgery ; Time Factors ; Young Adult</subject><ispartof>Surgery for obesity and related diseases, 2016-01, Vol.12 (1), p.70-74</ispartof><rights>American Society for Bariatric Surgery</rights><rights>2016 American Society for Bariatric Surgery</rights><rights>Copyright © 2016 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-7ac0be2d91db4c7aca6c031bc753798e720bc2273ba64fb987a02c41da4c03e53</citedby><cites>FETCH-LOGICAL-c484t-7ac0be2d91db4c7aca6c031bc753798e720bc2273ba64fb987a02c41da4c03e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1550728915000532$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25862184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>del Genio, Gianmattia, M.D., Ph.D., F.A.C.S</creatorcontrib><creatorcontrib>Limongelli, Paolo, M.D., Ph.D</creatorcontrib><creatorcontrib>del Genio, Federica, M.D., Ph.D</creatorcontrib><creatorcontrib>Motta, Gaetano, M.D</creatorcontrib><creatorcontrib>Docimo, Ludovico, M.D., Ph.D</creatorcontrib><creatorcontrib>Testa, Domenico, M.D</creatorcontrib><title>Sleeve gastrectomy improves obstructive sleep apnea syndrome (OSAS): 5 year longitudinal study</title><title>Surgery for obesity and related diseases</title><addtitle>Surg Obes Relat Dis</addtitle><description>Abstract Background Obstructive sleep apnea syndrome (OSAS) is prevalent among morbidly obese patients. Evaluation of the specific effects of sleeve gastrectomy (SG) on upper airway function has not been reported. Given the possibility that some patients will not respond despite weight loss, no studies have investigated whether other mechanisms may be responsible for persistent OSAS after bariatric surgery. Objectives To evaluate by subjective and objective assessment the impact of SG on upper respiratory physiology in the long-term. Setting University Hospital, Division of Bariatric and ENT Surgery, in Italy. Methods Thirty-six consecutive patients with OSAS who underwent laparoscopic SG were prospectively enrolled. The effect of SG on respiratory function and OSAS was followed for 5 years. Results All patients completed the 5-year follow-up. A significant ( P <.001) improvement in modified Epworth Sleepiness Scale questionnaire (ESS) was obtained in 91.6% (33/36) of patients. The Apnea/Hypopnea index (AHI) improved in 80.6% (29/36) of patients after surgery (from 32.8±1.7 to 5.8±1.2 ( P <.001), 4.9±1.7). The remaining 19.4% (7/36) of patients with a positive ESS and/or AHI all had an associated respiratory resistance due to nasal obstructive diseases. Conclusion SG improved OSAS overall, but patients who did not improve or only partially improved despite weight loss were found to have an associated nasal responsible pathology. How these patients will respond to nasal surgery and whether a 2-step procedure should be recommended for OSAS patients requires further study.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bariatric surgery</subject><subject>Disease Progression</subject><subject>ENT</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrectomy - methods</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - surgery</subject><subject>OSAS</subject><subject>Polysomnography</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Sleep Apnea, Obstructive - etiology</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Sleeve gastrectomy</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1550-7289</issn><issn>1878-7533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7of-AkFyXA89VpJOJy0oLIurwsIeRq-GdFKzZOzujEn3QP97087qwYtQkEp43qrUW4S8YrBhwJq3-02ONvkNByY3wEvAE3LOtNKVkkI8LbmUUCmu2zNykfMeQDRS8efkjEvdcKbrc_J92yMekT7YPCV0UxwWGoZDikfMNHblcXZTKEAu3IHaw4iW5mX0KQ5Ir-6319s376ikC9pE-zg-hGn2YbQ9zSVZXpBnO9tnfPl4XpJvtx-_3nyu7u4_fbm5vqtcreupUtZBh9y3zHe1KzfbOBCsc2UQ1WpUHDrHuRKdbepd12plgbuaeVsXDqW4JFenuuXnP2fMkxlCdtj3dsQ4Z8NUA7plbSMKKk6oSzHnhDtzSGGwaTEMzGqs2ZvfxprVWAO8BBTV68cGczeg_6v542QB3p8ALGMeAyaTXcDRoQ-rr8bH8J8GH_7Ruz6Mwdn-By6Y93FOxdUyiclFYLbrbtfVMgkAUnDxCxLVoFc</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>del Genio, Gianmattia, M.D., Ph.D., F.A.C.S</creator><creator>Limongelli, Paolo, M.D., Ph.D</creator><creator>del Genio, Federica, M.D., Ph.D</creator><creator>Motta, Gaetano, M.D</creator><creator>Docimo, Ludovico, M.D., Ph.D</creator><creator>Testa, Domenico, M.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Sleeve gastrectomy improves obstructive sleep apnea syndrome (OSAS): 5 year longitudinal study</title><author>del Genio, Gianmattia, M.D., Ph.D., F.A.C.S ; Limongelli, Paolo, M.D., Ph.D ; del Genio, Federica, M.D., Ph.D ; Motta, Gaetano, M.D ; Docimo, Ludovico, M.D., Ph.D ; Testa, Domenico, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-7ac0be2d91db4c7aca6c031bc753798e720bc2273ba64fb987a02c41da4c03e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bariatric surgery</topic><topic>Disease Progression</topic><topic>ENT</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrectomy - methods</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - surgery</topic><topic>OSAS</topic><topic>Polysomnography</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>Sleep Apnea, Obstructive - etiology</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Sleeve gastrectomy</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>del Genio, Gianmattia, M.D., Ph.D., F.A.C.S</creatorcontrib><creatorcontrib>Limongelli, Paolo, M.D., Ph.D</creatorcontrib><creatorcontrib>del Genio, Federica, M.D., Ph.D</creatorcontrib><creatorcontrib>Motta, Gaetano, M.D</creatorcontrib><creatorcontrib>Docimo, Ludovico, M.D., Ph.D</creatorcontrib><creatorcontrib>Testa, Domenico, M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery for obesity and related diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>del Genio, Gianmattia, M.D., Ph.D., F.A.C.S</au><au>Limongelli, Paolo, M.D., Ph.D</au><au>del Genio, Federica, M.D., Ph.D</au><au>Motta, Gaetano, M.D</au><au>Docimo, Ludovico, M.D., Ph.D</au><au>Testa, Domenico, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleeve gastrectomy improves obstructive sleep apnea syndrome (OSAS): 5 year longitudinal study</atitle><jtitle>Surgery for obesity and related diseases</jtitle><addtitle>Surg Obes Relat Dis</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>12</volume><issue>1</issue><spage>70</spage><epage>74</epage><pages>70-74</pages><issn>1550-7289</issn><eissn>1878-7533</eissn><abstract>Abstract Background Obstructive sleep apnea syndrome (OSAS) is prevalent among morbidly obese patients. Evaluation of the specific effects of sleeve gastrectomy (SG) on upper airway function has not been reported. Given the possibility that some patients will not respond despite weight loss, no studies have investigated whether other mechanisms may be responsible for persistent OSAS after bariatric surgery. Objectives To evaluate by subjective and objective assessment the impact of SG on upper respiratory physiology in the long-term. Setting University Hospital, Division of Bariatric and ENT Surgery, in Italy. Methods Thirty-six consecutive patients with OSAS who underwent laparoscopic SG were prospectively enrolled. The effect of SG on respiratory function and OSAS was followed for 5 years. Results All patients completed the 5-year follow-up. A significant ( P <.001) improvement in modified Epworth Sleepiness Scale questionnaire (ESS) was obtained in 91.6% (33/36) of patients. The Apnea/Hypopnea index (AHI) improved in 80.6% (29/36) of patients after surgery (from 32.8±1.7 to 5.8±1.2 ( P <.001), 4.9±1.7). The remaining 19.4% (7/36) of patients with a positive ESS and/or AHI all had an associated respiratory resistance due to nasal obstructive diseases. Conclusion SG improved OSAS overall, but patients who did not improve or only partially improved despite weight loss were found to have an associated nasal responsible pathology. How these patients will respond to nasal surgery and whether a 2-step procedure should be recommended for OSAS patients requires further study.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25862184</pmid><doi>10.1016/j.soard.2015.02.020</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Bariatric surgery Disease Progression ENT Female Follow-Up Studies Gastrectomy - methods Gastroenterology and Hepatology Humans Italy - epidemiology Male Middle Aged Obesity, Morbid - complications Obesity, Morbid - surgery OSAS Polysomnography Prevalence Prospective Studies Severity of Illness Index Sleep Apnea, Obstructive - epidemiology Sleep Apnea, Obstructive - etiology Sleep Apnea, Obstructive - physiopathology Sleeve gastrectomy Surgery Time Factors Young Adult |
| title | Sleeve gastrectomy improves obstructive sleep apnea syndrome (OSAS): 5 year longitudinal study |
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