Environmentally Robust Rhodamine Reporters for Probe-based Cellular Detection of the Cancer-linked Oxidoreductase hNQO1

We successfully synthesized a fluorescent probe capable of detecting the cancer-associated NAD­(P)­H:quinoneoxidoreductase isozyme-1 within human cells, based on results from an investigation of the stability of various rhodamines and seminaphthorhodamines toward the biological reductant NADH, prese...

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Veröffentlicht in:	ACS chemical biology 2016-01, Vol.11 (1), p.231-240
Hauptverfasser:	Best, Quinn A., Johnson, Amanda E., Prasai, Bijeta, Rouillere, Alexandra, McCarley, Robin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Fluorescent Dyes - chemistry Humans Kinetics Molecular Structure NAD(P)H Dehydrogenase (Quinone) - analysis NAD(P)H Dehydrogenase (Quinone) - chemistry NAD(P)H Dehydrogenase (Quinone) - metabolism Neoplasms - diagnosis Neoplasms - enzymology Rhodamines - chemistry
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