Diol Dehydratase-Reactivase Is Essential for Recycling of Coenzyme B12 in Diol Dehydratase

Holoenzymes of adenosylcobalamin-dependent diol and glycerol dehydratases undergo mechanism-based inactivation by glycerol and O2 inactivation in the absence of substrate, which accompanies irreversible cleavage of the coenzyme Co–C bond. The inactivated holodiol dehydratase and the inactive enzyme·...

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Veröffentlicht in:	Biochemistry (Easton) 2016-01, Vol.55 (1), p.69-78
Hauptverfasser:	Toraya, Tetsuo, Tanokuchi, Aya, Yamasaki, Ai, Nakamura, Takehiro, Ogura, Kenichi, Tobimatsu, Takamasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Alkyl and Aryl Transferases - metabolism Bacterial Proteins - metabolism Cobamides - metabolism Enzyme Activation Flavin Mononucleotide - metabolism Hydroquinones - metabolism Klebsiella oxytoca - enzymology Klebsiella oxytoca - metabolism Magnesium - metabolism NAD - metabolism Propanediol Dehydratase - metabolism
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