Phosphine-Catalyzed β,γ-Umpolung Domino Reaction of Allenic Esters: Facile Synthesis of Tetrahydrobenzofuranones Bearing a Chiral Tetrasubstituted Stereogenic Carbon Center

An enantio‐, diastereo‐, regio‐, and chemoselective phosphine‐catalyzed β,γ‐umpolung domino reaction of allenic esters with dienones has been developed for the first time. The designed sequence, involving oxy‐Michael and Rauhut–Currier reactions, produced highly functionalized tetrahydrobenzofuranon...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-12, Vol.54 (51), p.15511-15515
Hauptverfasser:	Takizawa, Shinobu, Kishi, Kenta, Yoshida, Yasushi, Mader, Steffen, Arteaga, Fernando Arteaga, Lee, Shoukou, Hoshino, Manabu, Rueping, Magnus, Fujita, Makoto, Sasai, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	allenes annulations Cascade chemical reactions Esters organocatalysis Phosphine Phosphines umpolung
Online-Zugang:	Volltext
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