Total Synthesis of Crotophorbolone

The complex ABC‐tricyclic structure of crotophorbolone, a derivative of the tigliane diterpenoids, was assembled by coupling of simple fragments. The six‐membered C‐ring fragment, having five contiguous stereocenters, was stereoselectively constructed from (R)‐carvone. After attachment of the five‐m...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-11, Vol.54 (48), p.14457-14461
Hauptverfasser:	Asaba, Taro, Katoh, Yuki, Urabe, Daisuke, Inoue, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Carvone Coupling cross-coupling Diterpenes Functional groups Hydroxylation Isomerization natural products Oxidation radical reactions Rhodium Synthesis terpenoids total synthesis
Online-Zugang:	Volltext
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