Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats
A sensitive bioluminogenic probe for highly reactive oxygen species (hROS), SO3H‐APL, was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme‐induced electron transfer (BioLeT) and modulation of cell‐membrane permeability. This probe enables n...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2015-12, Vol.54 (49), p.14768-14771 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Kojima, Ryosuke Takakura, Hideo Kamiya, Mako Kobayashi, Eiji Komatsu, Toru Ueno, Tasuku Terai, Takuya Hanaoka, Kenjiro Nagano, Tetsuo Urano, Yasuteru |
| description | A sensitive bioluminogenic probe for highly reactive oxygen species (hROS), SO3H‐APL, was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme‐induced electron transfer (BioLeT) and modulation of cell‐membrane permeability. This probe enables non‐invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats for the first time. It is expected to serve as a practical analytical tool for investigating a wide range of biological functions of hROS in vivo. The design concept should be applicable to other in vivo bioluminogenic probes.
You light up my life: A sensitive bioluminogenic probe for highly reactive oxygen species (hROS) was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme‐induced electron transfer (BioLeT) and modulation of cell‐membrane permeability. This probe enables non‐invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats. |
| doi_str_mv | 10.1002/anie.201507530 |
| format | Article |
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You light up my life: A sensitive bioluminogenic probe for highly reactive oxygen species (hROS) was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme‐induced electron transfer (BioLeT) and modulation of cell‐membrane permeability. This probe enables non‐invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201507530</identifier><identifier>PMID: 26474404</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; Bioluminescence ; Electron transfer ; Emissions control ; imaging agents ; In vivo methods and tests ; Luciferases - genetics ; Luciferases - metabolism ; luminescence ; Luminescent Agents - administration & dosage ; Luminescent Agents - analysis ; Luminescent Agents - chemical synthesis ; Luminescent Agents - chemistry ; Luminescent Measurements ; Membrane permeability ; Molecular Structure ; Oxygen ; Rats ; Rats, Transgenic ; Reactive oxygen species ; Reactive Oxygen Species - analysis ; Reactive Oxygen Species - metabolism</subject><ispartof>Angewandte Chemie International Edition, 2015-12, Vol.54 (49), p.14768-14771</ispartof><rights>2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright Wiley Subscription Services, Inc. Dec 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6450-453dbc4a46929e67234e310ce8731001eff2bac972a544a6dac03a54771abf313</citedby><cites>FETCH-LOGICAL-c6450-453dbc4a46929e67234e310ce8731001eff2bac972a544a6dac03a54771abf313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201507530$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201507530$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26474404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kojima, Ryosuke</creatorcontrib><creatorcontrib>Takakura, Hideo</creatorcontrib><creatorcontrib>Kamiya, Mako</creatorcontrib><creatorcontrib>Kobayashi, Eiji</creatorcontrib><creatorcontrib>Komatsu, Toru</creatorcontrib><creatorcontrib>Ueno, Tasuku</creatorcontrib><creatorcontrib>Terai, Takuya</creatorcontrib><creatorcontrib>Hanaoka, Kenjiro</creatorcontrib><creatorcontrib>Nagano, Tetsuo</creatorcontrib><creatorcontrib>Urano, Yasuteru</creatorcontrib><title>Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>A sensitive bioluminogenic probe for highly reactive oxygen species (hROS), SO3H‐APL, was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme‐induced electron transfer (BioLeT) and modulation of cell‐membrane permeability. This probe enables non‐invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats for the first time. It is expected to serve as a practical analytical tool for investigating a wide range of biological functions of hROS in vivo. The design concept should be applicable to other in vivo bioluminogenic probes.
You light up my life: A sensitive bioluminogenic probe for highly reactive oxygen species (hROS) was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme‐induced electron transfer (BioLeT) and modulation of cell‐membrane permeability. This probe enables non‐invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats.</description><subject>Animals</subject><subject>Bioluminescence</subject><subject>Electron transfer</subject><subject>Emissions control</subject><subject>imaging agents</subject><subject>In vivo methods and tests</subject><subject>Luciferases - genetics</subject><subject>Luciferases - metabolism</subject><subject>luminescence</subject><subject>Luminescent Agents - administration & dosage</subject><subject>Luminescent Agents - analysis</subject><subject>Luminescent Agents - chemical synthesis</subject><subject>Luminescent Agents - chemistry</subject><subject>Luminescent Measurements</subject><subject>Membrane permeability</subject><subject>Molecular Structure</subject><subject>Oxygen</subject><subject>Rats</subject><subject>Rats, Transgenic</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - analysis</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEURS0EoqWwZYkssWEzwd-eWZZS2khRG7WgSmwsj_MmuMyMU3smbf59HVIixAJW7y3OPbbeRegtJRNKCPtoew8TRqgkWnLyDB1SyWjBtebP8y44L3Qp6QF6ldJt5suSqJfogCmhhSDiEPnPsIY2rDroBxwabPE19MkPfg34kw_t2Pk-LKH3Ds9jqAE3IeJpZ5e-X-Jzv_zRbvAVWPcrcPmwySi-XoHzkLDv8cyvt-CVHdJr9KKxbYI3T_MIffty-vXkvJhdnk1PjmeFU0KSQki-qJ2wQlWsAqUZF8ApcVDqPAiFpmG1dZVmVgph1cI6wvOqNbV1wyk_Qh923lUMdyOkwXQ-OWhb20MYk6FakbLM16oy-v4v9DaMsc-_M0xUgpSMc_YvKrsU05TL7bOTHeViSClCY1bRdzZuDCVmW5XZVmX2VeXAuyftWHew2OO_u8lAtQPufQub_-jM8cX09E95scv6NMDDPmvjT6M019LcXJwZMp_LOft-YyR_BBHkrTY</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Kojima, Ryosuke</creator><creator>Takakura, Hideo</creator><creator>Kamiya, Mako</creator><creator>Kobayashi, Eiji</creator><creator>Komatsu, Toru</creator><creator>Ueno, Tasuku</creator><creator>Terai, Takuya</creator><creator>Hanaoka, Kenjiro</creator><creator>Nagano, Tetsuo</creator><creator>Urano, Yasuteru</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats</title><author>Kojima, Ryosuke ; Takakura, Hideo ; Kamiya, Mako ; Kobayashi, Eiji ; Komatsu, Toru ; Ueno, Tasuku ; Terai, Takuya ; Hanaoka, Kenjiro ; Nagano, Tetsuo ; Urano, Yasuteru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6450-453dbc4a46929e67234e310ce8731001eff2bac972a544a6dac03a54771abf313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Bioluminescence</topic><topic>Electron transfer</topic><topic>Emissions control</topic><topic>imaging agents</topic><topic>In vivo methods and tests</topic><topic>Luciferases - genetics</topic><topic>Luciferases - metabolism</topic><topic>luminescence</topic><topic>Luminescent Agents - administration & dosage</topic><topic>Luminescent Agents - analysis</topic><topic>Luminescent Agents - chemical synthesis</topic><topic>Luminescent Agents - chemistry</topic><topic>Luminescent Measurements</topic><topic>Membrane permeability</topic><topic>Molecular Structure</topic><topic>Oxygen</topic><topic>Rats</topic><topic>Rats, Transgenic</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - analysis</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kojima, Ryosuke</creatorcontrib><creatorcontrib>Takakura, Hideo</creatorcontrib><creatorcontrib>Kamiya, Mako</creatorcontrib><creatorcontrib>Kobayashi, Eiji</creatorcontrib><creatorcontrib>Komatsu, Toru</creatorcontrib><creatorcontrib>Ueno, Tasuku</creatorcontrib><creatorcontrib>Terai, Takuya</creatorcontrib><creatorcontrib>Hanaoka, Kenjiro</creatorcontrib><creatorcontrib>Nagano, Tetsuo</creatorcontrib><creatorcontrib>Urano, Yasuteru</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kojima, Ryosuke</au><au>Takakura, Hideo</au><au>Kamiya, Mako</au><au>Kobayashi, Eiji</au><au>Komatsu, Toru</au><au>Ueno, Tasuku</au><au>Terai, Takuya</au><au>Hanaoka, Kenjiro</au><au>Nagano, Tetsuo</au><au>Urano, Yasuteru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>54</volume><issue>49</issue><spage>14768</spage><epage>14771</epage><pages>14768-14771</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>A sensitive bioluminogenic probe for highly reactive oxygen species (hROS), SO3H‐APL, was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme‐induced electron transfer (BioLeT) and modulation of cell‐membrane permeability. This probe enables non‐invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats for the first time. It is expected to serve as a practical analytical tool for investigating a wide range of biological functions of hROS in vivo. The design concept should be applicable to other in vivo bioluminogenic probes.
You light up my life: A sensitive bioluminogenic probe for highly reactive oxygen species (hROS) was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme‐induced electron transfer (BioLeT) and modulation of cell‐membrane permeability. This probe enables non‐invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>26474404</pmid><doi>10.1002/anie.201507530</doi><tpages>4</tpages><edition>International ed. in English</edition></addata></record> |
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| subjects | Animals Bioluminescence Electron transfer Emissions control imaging agents In vivo methods and tests Luciferases - genetics Luciferases - metabolism luminescence Luminescent Agents - administration & dosage Luminescent Agents - analysis Luminescent Agents - chemical synthesis Luminescent Agents - chemistry Luminescent Measurements Membrane permeability Molecular Structure Oxygen Rats Rats, Transgenic Reactive oxygen species Reactive Oxygen Species - analysis Reactive Oxygen Species - metabolism |
| title | Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats |
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