Mechanisms of the role of fibroblast growth factor 21 in attenuating insulin resistance
This study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on type 2 diabetic mice model and to provide mechanistic insights into its therapeutic effect. Type 2 diabetic animal model was established with high calorie fat diet and low dose streptozotocin (STZ) injection....
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| Veröffentlicht in: | Yao hsüeh hsüeh pao 2015-09, Vol.50 (9), p.1101-1106 |
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| container_title | Yao hsüeh hsüeh pao |
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| creator | Xu, Tong-yu Wang, Wen-fei Xu, Peng-fei Yuan, Qing-yan Liu, Shuang-qing Zhnag, Tong Ren, Gui-ping Li, De-shan |
| description | This study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on type 2 diabetic mice model and to provide mechanistic insights into its therapeutic effect. Type 2 diabetic animal model was established with high calorie fat diet and low dose streptozotocin (STZ) injection. Mice were then randomized into 5 groups: model control, FGF21 0.25 and 0.05 μmol x kg(-1) x d(-1) groups, insulin treatment group. Ten age-matched normal KM mouse administered with saline were used as normal controls. Serum glucose, insulin, lipid products and the change of serum and liver tissue inflammation factor levels between five groups of mouse were determined. The results showed that blood glucose, insulin, free fatty acids (FFAs), triglycerides, and inflammatory factor average FGF-21 of type 2 diabetes model group and normal control group were significantly higher (P < 0.01), while compared with insulin group, no difference was significant. Average blood glucose, insulin, blood lipid and inflammatory facto |
| format | Article |
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Type 2 diabetic animal model was established with high calorie fat diet and low dose streptozotocin (STZ) injection. Mice were then randomized into 5 groups: model control, FGF21 0.25 and 0.05 μmol x kg(-1) x d(-1) groups, insulin treatment group. Ten age-matched normal KM mouse administered with saline were used as normal controls. Serum glucose, insulin, lipid products and the change of serum and liver tissue inflammation factor levels between five groups of mouse were determined. The results showed that blood glucose, insulin, free fatty acids (FFAs), triglycerides, and inflammatory factor average FGF-21 of type 2 diabetes model group and normal control group were significantly higher (P < 0.01), while compared with insulin group, no difference was significant. Average blood glucose, insulin, blood lipid and inflammatory facto</description><identifier>ISSN: 0513-4870</identifier><identifier>PMID: 26757545</identifier><language>chi</language><publisher>China</publisher><subject>Animals ; Blood Glucose ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Type 2 - drug therapy ; Diet, High-Fat ; Fatty Acids, Nonesterified - blood ; Fibroblast Growth Factors - pharmacology ; Insulin - blood ; Insulin Resistance ; Mice ; Streptozocin ; Triglycerides - blood</subject><ispartof>Yao hsüeh hsüeh pao, 2015-09, Vol.50 (9), p.1101-1106</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26757545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Tong-yu</creatorcontrib><creatorcontrib>Wang, Wen-fei</creatorcontrib><creatorcontrib>Xu, Peng-fei</creatorcontrib><creatorcontrib>Yuan, Qing-yan</creatorcontrib><creatorcontrib>Liu, Shuang-qing</creatorcontrib><creatorcontrib>Zhnag, Tong</creatorcontrib><creatorcontrib>Ren, Gui-ping</creatorcontrib><creatorcontrib>Li, De-shan</creatorcontrib><title>Mechanisms of the role of fibroblast growth factor 21 in attenuating insulin resistance</title><title>Yao hsüeh hsüeh pao</title><addtitle>Yao Xue Xue Bao</addtitle><description>This study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on type 2 diabetic mice model and to provide mechanistic insights into its therapeutic effect. Type 2 diabetic animal model was established with high calorie fat diet and low dose streptozotocin (STZ) injection. Mice were then randomized into 5 groups: model control, FGF21 0.25 and 0.05 μmol x kg(-1) x d(-1) groups, insulin treatment group. Ten age-matched normal KM mouse administered with saline were used as normal controls. Serum glucose, insulin, lipid products and the change of serum and liver tissue inflammation factor levels between five groups of mouse were determined. The results showed that blood glucose, insulin, free fatty acids (FFAs), triglycerides, and inflammatory factor average FGF-21 of type 2 diabetes model group and normal control group were significantly higher (P < 0.01), while compared with insulin group, no difference was significant. Average blood glucose, insulin, blood lipid and inflammatory facto</description><subject>Animals</subject><subject>Blood Glucose</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diet, High-Fat</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Fibroblast Growth Factors - pharmacology</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Mice</subject><subject>Streptozocin</subject><subject>Triglycerides - blood</subject><issn>0513-4870</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UEtLxDAYzEFx19W_IDl6KeSd9CiLL1jxongsafplG2mbNUkR_72VXU_zYBiYOUNrIimvhNFkhS5z_iRE0JqbC7RiSksthVyjjxdwvZ1CHjOOHpcecIoD_HEf2hTbweaC9yl-lx5760pMmFEcJmxLgWm2JUz7ReZ5WLwEOeRiJwdX6NzbIcP1CTfo_eH-bftU7V4fn7d3u-pAmSpVK6XVjhiqXN2Bb5njQmjDleFUMCYpLBMkd6zriDWeqI5TA5ZJ6ZQUi9qg22PvIcWvGXJpxpAdDIOdIM65oVoRY1St9BK9OUXndoSuOaQw2vTT_J_BfwH641nJ</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Xu, Tong-yu</creator><creator>Wang, Wen-fei</creator><creator>Xu, Peng-fei</creator><creator>Yuan, Qing-yan</creator><creator>Liu, Shuang-qing</creator><creator>Zhnag, Tong</creator><creator>Ren, Gui-ping</creator><creator>Li, De-shan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Mechanisms of the role of fibroblast growth factor 21 in attenuating insulin resistance</title><author>Xu, Tong-yu ; Wang, Wen-fei ; Xu, Peng-fei ; Yuan, Qing-yan ; Liu, Shuang-qing ; Zhnag, Tong ; Ren, Gui-ping ; Li, De-shan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-b55a7c0816c9defb2c344783683142251e51353c2dd0a8f06d318ea255c6546d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Blood Glucose</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diet, High-Fat</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Fibroblast Growth Factors - pharmacology</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Mice</topic><topic>Streptozocin</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Tong-yu</creatorcontrib><creatorcontrib>Wang, Wen-fei</creatorcontrib><creatorcontrib>Xu, Peng-fei</creatorcontrib><creatorcontrib>Yuan, Qing-yan</creatorcontrib><creatorcontrib>Liu, Shuang-qing</creatorcontrib><creatorcontrib>Zhnag, Tong</creatorcontrib><creatorcontrib>Ren, Gui-ping</creatorcontrib><creatorcontrib>Li, De-shan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Yao hsüeh hsüeh pao</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Tong-yu</au><au>Wang, Wen-fei</au><au>Xu, Peng-fei</au><au>Yuan, Qing-yan</au><au>Liu, Shuang-qing</au><au>Zhnag, Tong</au><au>Ren, Gui-ping</au><au>Li, De-shan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of the role of fibroblast growth factor 21 in attenuating insulin resistance</atitle><jtitle>Yao hsüeh hsüeh pao</jtitle><addtitle>Yao Xue Xue Bao</addtitle><date>2015-09</date><risdate>2015</risdate><volume>50</volume><issue>9</issue><spage>1101</spage><epage>1106</epage><pages>1101-1106</pages><issn>0513-4870</issn><abstract>This study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on type 2 diabetic mice model and to provide mechanistic insights into its therapeutic effect. 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| subjects | Animals Blood Glucose Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - drug therapy Diet, High-Fat Fatty Acids, Nonesterified - blood Fibroblast Growth Factors - pharmacology Insulin - blood Insulin Resistance Mice Streptozocin Triglycerides - blood |
| title | Mechanisms of the role of fibroblast growth factor 21 in attenuating insulin resistance |
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