Plasma 8-isoPGF2α and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease
F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether...
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| Veröffentlicht in: | Turkish journal of medical sciences 2015, Vol.45 (5), p.1073-1077 |
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| container_issue | 5 |
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| container_title | Turkish journal of medical sciences |
| container_volume | 45 |
| creator | Sirin, Fevziye Burcu Kumbul Doğuç, Duygu Vural, Hüseyin Eren, Ibrahim Inanli, Ikbal Sütçü, Recep Delibaş, Namik |
| description | F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not.
Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method.
Significant differences were observed in the melatonin levels between the MCI group and AD group (P = 0.009), and in 8-isoPGF2α levels between the AD group and control group (P = 0.022). A negative correlation between mini-mental state examination (MMSE) scores and 8-isoPGF2a levels (r = -0.459, P < 0.001) and positive correlation between MMSE scores and melatonin levels (r = 0.317, P = 0.011) were found.
Although the plasma 8-isoPGF2α and serum melatonin levels in MCI were not found to be good early diagnostic markers to indicate risk of AD, results were found to support the role of oxidative stress in AD. |
| doi_str_mv | 10.3906/sag-1406-134 |
| format | Article |
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Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method.
Significant differences were observed in the melatonin levels between the MCI group and AD group (P = 0.009), and in 8-isoPGF2α levels between the AD group and control group (P = 0.022). A negative correlation between mini-mental state examination (MMSE) scores and 8-isoPGF2a levels (r = -0.459, P < 0.001) and positive correlation between MMSE scores and melatonin levels (r = 0.317, P = 0.011) were found.
Although the plasma 8-isoPGF2α and serum melatonin levels in MCI were not found to be good early diagnostic markers to indicate risk of AD, results were found to support the role of oxidative stress in AD.</description><identifier>ISSN: 1300-0144</identifier><identifier>EISSN: 1303-6165</identifier><identifier>DOI: 10.3906/sag-1406-134</identifier><identifier>PMID: 26738349</identifier><language>eng</language><publisher>Turkey</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - blood ; Alzheimer Disease - diagnosis ; Biomarkers - blood ; Case-Control Studies ; Cognitive Dysfunction - blood ; Cognitive Dysfunction - diagnosis ; Dinoprost - analogs & derivatives ; Dinoprost - blood ; Early Diagnosis ; Female ; Humans ; Male ; Melatonin - blood ; Oxidative Stress</subject><ispartof>Turkish journal of medical sciences, 2015, Vol.45 (5), p.1073-1077</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-ae8811dc6b53adca78c5279b0be25cc0c268b25f218c3f4b5dea4ea4ba54adae3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26738349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sirin, Fevziye Burcu</creatorcontrib><creatorcontrib>Kumbul Doğuç, Duygu</creatorcontrib><creatorcontrib>Vural, Hüseyin</creatorcontrib><creatorcontrib>Eren, Ibrahim</creatorcontrib><creatorcontrib>Inanli, Ikbal</creatorcontrib><creatorcontrib>Sütçü, Recep</creatorcontrib><creatorcontrib>Delibaş, Namik</creatorcontrib><title>Plasma 8-isoPGF2α and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease</title><title>Turkish journal of medical sciences</title><addtitle>Turk J Med Sci</addtitle><description>F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not.
Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method.
Significant differences were observed in the melatonin levels between the MCI group and AD group (P = 0.009), and in 8-isoPGF2α levels between the AD group and control group (P = 0.022). A negative correlation between mini-mental state examination (MMSE) scores and 8-isoPGF2a levels (r = -0.459, P < 0.001) and positive correlation between MMSE scores and melatonin levels (r = 0.317, P = 0.011) were found.
Although the plasma 8-isoPGF2α and serum melatonin levels in MCI were not found to be good early diagnostic markers to indicate risk of AD, results were found to support the role of oxidative stress in AD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - blood</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Cognitive Dysfunction - blood</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Dinoprost - blood</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Melatonin - blood</subject><subject>Oxidative Stress</subject><issn>1300-0144</issn><issn>1303-6165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1Kw0AUhQdRrFZ3rmWWLozOXyaTpYitQsEudB1uJrftyEzSZlJF38oX8ZlMfxQunLP4OHA_Qi44u5E507cR5glXTCdcqgNywiWTieY6Pdx2ljCu1ICcxvjGmJAqzY_JQOhMGqnyE7KaeogBqElcbKbjkfj5plBXNGK7DjSgh66pXU09vqOPtG9L6BzWXaQfrlvQ4GoXwFPbzGvXuXekLizBtaFHtkN3_muBLmBLKxcRIp6Roxn4iOf7HJLX0cPL_WMyeR4_3d9NEitF3iWAxnBeWV2mEioLmbGpyPKSlShSa5kV2pQinQlurJypMq0QVH8lpAoqQDkkV7vdZdus1hi7Irho0XuosVnHgmeaGaMzznr0eofatomxxVmxbPuv2s-Cs2IjueglFxvJRS-5xy_3y-syYPUP_1mVv7izevg</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Sirin, Fevziye Burcu</creator><creator>Kumbul Doğuç, Duygu</creator><creator>Vural, Hüseyin</creator><creator>Eren, Ibrahim</creator><creator>Inanli, Ikbal</creator><creator>Sütçü, Recep</creator><creator>Delibaş, Namik</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2015</creationdate><title>Plasma 8-isoPGF2α and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease</title><author>Sirin, Fevziye Burcu ; Kumbul Doğuç, Duygu ; Vural, Hüseyin ; Eren, Ibrahim ; Inanli, Ikbal ; Sütçü, Recep ; Delibaş, Namik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-ae8811dc6b53adca78c5279b0be25cc0c268b25f218c3f4b5dea4ea4ba54adae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - blood</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Cognitive Dysfunction - blood</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Dinoprost - analogs & derivatives</topic><topic>Dinoprost - blood</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Melatonin - blood</topic><topic>Oxidative Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sirin, Fevziye Burcu</creatorcontrib><creatorcontrib>Kumbul Doğuç, Duygu</creatorcontrib><creatorcontrib>Vural, Hüseyin</creatorcontrib><creatorcontrib>Eren, Ibrahim</creatorcontrib><creatorcontrib>Inanli, Ikbal</creatorcontrib><creatorcontrib>Sütçü, Recep</creatorcontrib><creatorcontrib>Delibaş, Namik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Turkish journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sirin, Fevziye Burcu</au><au>Kumbul Doğuç, Duygu</au><au>Vural, Hüseyin</au><au>Eren, Ibrahim</au><au>Inanli, Ikbal</au><au>Sütçü, Recep</au><au>Delibaş, Namik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma 8-isoPGF2α and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease</atitle><jtitle>Turkish journal of medical sciences</jtitle><addtitle>Turk J Med Sci</addtitle><date>2015</date><risdate>2015</risdate><volume>45</volume><issue>5</issue><spage>1073</spage><epage>1077</epage><pages>1073-1077</pages><issn>1300-0144</issn><eissn>1303-6165</eissn><abstract>F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not.
Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method.
Significant differences were observed in the melatonin levels between the MCI group and AD group (P = 0.009), and in 8-isoPGF2α levels between the AD group and control group (P = 0.022). A negative correlation between mini-mental state examination (MMSE) scores and 8-isoPGF2a levels (r = -0.459, P < 0.001) and positive correlation between MMSE scores and melatonin levels (r = 0.317, P = 0.011) were found.
Although the plasma 8-isoPGF2α and serum melatonin levels in MCI were not found to be good early diagnostic markers to indicate risk of AD, results were found to support the role of oxidative stress in AD.</abstract><cop>Turkey</cop><pmid>26738349</pmid><doi>10.3906/sag-1406-134</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; TÜBİTAK Scientific Journals |
| subjects | Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - diagnosis Biomarkers - blood Case-Control Studies Cognitive Dysfunction - blood Cognitive Dysfunction - diagnosis Dinoprost - analogs & derivatives Dinoprost - blood Early Diagnosis Female Humans Male Melatonin - blood Oxidative Stress |
| title | Plasma 8-isoPGF2α and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease |
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