How Sensitive is the Amide I Vibration of the Polypeptide Backbone to Electric Fields?

Site‐selective isotopic labeling of amide carbonyls offers a nonperturbative means to introduce a localized infrared probe into proteins. Although this strategy has been widely used to investigate various biological questions, the dependence of the underlying amide I vibrational frequency on electri...

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Veröffentlicht in:	Chemphyschem 2015-12, Vol.16 (17), p.3595-3598
Hauptverfasser:	Oh, Kwang-Im, Fiorin, Giacomo, Gai, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	amide I vibration Amides - chemistry Electricity IR spectroscopy membrane electric field molecular dynamics Molecular Dynamics Simulation Peptides - chemistry Stark tuning rate Vibration
Online-Zugang:	Volltext
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