Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice

The X-linked Plac1 gene is maternally expressed in trophoblast cells during placentation, and its disruption causes placental hyperplasia and intrauterine growth restriction. In contrast, Plac1 is also reported to be one of the upregulated genes in the hyperplastic placenta generated by nuclear tran...

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Veröffentlicht in:	Biology of reproduction 2016-01, Vol.94 (1), p.6-6
Hauptverfasser:	Muto, Masanaga, Fujihara, Yoshitaka, Tobita, Tomohiro, Kiyozumi, Daiji, Ikawa, Masahito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst - metabolism Cell Proliferation Female Fetal Growth Retardation - genetics Fetal Growth Retardation - pathology Fetal Viability - genetics Gene Expression Regulation, Developmental Genetic Complementation Test Genetic Vectors Hyperplasia Lentivirus - genetics Mice Mice, Knockout Nuclear Transfer Techniques Placenta - pathology Pregnancy Pregnancy Proteins - deficiency Pregnancy Proteins - genetics Transgenes - genetics Trophoblasts
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