Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

The aggressive phenotype displayed by fibroblast-like synoviocytes (FLSs) is a critical factor of cartilage destruction in rheumatoid arthritis (RA). Increased FLSs migration and subsequent degradation of the extracellular matrix are essential to the pathology of RA. Protein inhibitor of activated S...

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Veröffentlicht in:	The Journal of immunology (1950) 2016-01, Vol.196 (2), p.596-606
Hauptverfasser:	Lao, Minxi, Shi, Maohua, Zou, Yaoyao, Huang, Mingcheng, Ye, Yujin, Qiu, Qian, Xiao, Youjun, Zeng, Shan, Liang, Liuqin, Yang, Xiuyan, Xu, Hanshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Blotting, Western Cell Movement Female Fibroblasts - metabolism Fibroblasts - pathology Fluorescent Antibody Technique Humans Immunohistochemistry Immunoprecipitation Male Middle Aged Molecular Chaperones - metabolism Protein Inhibitors of Activated STAT - metabolism Real-Time Polymerase Chain Reaction Signal Transduction - physiology Synovial Membrane - metabolism Synovial Membrane - pathology
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