Low Quality of Life and Depressive Symptoms as an Independent Risk Factor for Erectile Dysfunction in Patients with Obstructive Sleep Apnea
Accumulating evidence indicates that obstructive sleep apnea (OSA) is associated with a high prevalence of erectile dysfunction (ED), but the factors that predict the risk of ED in OSA patients have yet to be defined clearly. The aims of the present study were to investigate the clinical characteris...
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| Veröffentlicht in: | Journal of sexual medicine 2015-11, Vol.12 (11), p.2168-2177 |
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| creator | Jeon, Yung Jin Yoon, Dae Wui Han, Doo Hee Won, Tae-Bin Kim, Dong-Young Shin, Hyun-Woo |
| description | Accumulating evidence indicates that obstructive sleep apnea (OSA) is associated with a high prevalence of erectile dysfunction (ED), but the factors that predict the risk of ED in OSA patients have yet to be defined clearly.
The aims of the present study were to investigate the clinical characteristics of OSA patients with ED and to identify plausible predictors of ED.
The present cross-sectional analysis included 713 male patients who visited Seoul National University Hospital for snoring and/or daytime sleepiness from 2006 to 2014. An in-laboratory polysomnography procedure was conducted to obtain objective recordings of OSA and other sleep parameters.
The demographic data of all patients were obtained, and each patient completed all requirements of the following questionnaires: the Calgary Sleep Apnea Quality of Life Index (SAQLI), the Korean version of the International Index of Erectile Function (KIIEF-5), the Beck Depression Inventory (BDI), and the Epworth Sleepiness Scale (ESS). ED and OSA were defined as a KIIEF-5 < 21 and a respiratory disturbance index (RDI) ≥ 5, respectively. Depressive symptoms were defined as a BDI ≥ 10.
The frequency of ED did not differ significantly according to OSA severity. In Spearman's correlation analysis, the BDI and the ESS were inversely correlated with the KIIEF-5, whereas the SAQLI was positively correlated with the KIIEF-5. The RDI and the lowest oxygen saturation (SaO2) did not exhibit significant correlations with the KIIEF-5. A multivariate logistic regression analysis adjusted for possible confounding factors showed that ED was independently associated with the SAQLI and depressive symptoms, but there was no significant association of ED with either the RDI or the lowest SaO2.
The present study demonstrated that depressive symptoms and a low quality of life specific to sleep apnea are independent risk factors for ED in OSA patients. |
| doi_str_mv | 10.1111/jsm.13021 |
| format | Article |
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The aims of the present study were to investigate the clinical characteristics of OSA patients with ED and to identify plausible predictors of ED.
The present cross-sectional analysis included 713 male patients who visited Seoul National University Hospital for snoring and/or daytime sleepiness from 2006 to 2014. An in-laboratory polysomnography procedure was conducted to obtain objective recordings of OSA and other sleep parameters.
The demographic data of all patients were obtained, and each patient completed all requirements of the following questionnaires: the Calgary Sleep Apnea Quality of Life Index (SAQLI), the Korean version of the International Index of Erectile Function (KIIEF-5), the Beck Depression Inventory (BDI), and the Epworth Sleepiness Scale (ESS). ED and OSA were defined as a KIIEF-5 < 21 and a respiratory disturbance index (RDI) ≥ 5, respectively. Depressive symptoms were defined as a BDI ≥ 10.
The frequency of ED did not differ significantly according to OSA severity. In Spearman's correlation analysis, the BDI and the ESS were inversely correlated with the KIIEF-5, whereas the SAQLI was positively correlated with the KIIEF-5. The RDI and the lowest oxygen saturation (SaO2) did not exhibit significant correlations with the KIIEF-5. A multivariate logistic regression analysis adjusted for possible confounding factors showed that ED was independently associated with the SAQLI and depressive symptoms, but there was no significant association of ED with either the RDI or the lowest SaO2.
The present study demonstrated that depressive symptoms and a low quality of life specific to sleep apnea are independent risk factors for ED in OSA patients.</description><identifier>ISSN: 1743-6095</identifier><identifier>EISSN: 1743-6109</identifier><identifier>DOI: 10.1111/jsm.13021</identifier><identifier>PMID: 26477542</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Aged ; Beck Depression Inventory ; Calgary Sleep Apnea Quality of Life Index ; Cross-Sectional Studies ; Depression - complications ; Depression - epidemiology ; Epworth Sleepiness Scale ; Erectile Dysfunction ; Erectile Dysfunction - epidemiology ; Erectile Dysfunction - etiology ; Erectile Dysfunction - psychology ; Female ; Humans ; International Index of Erectile Function ; Male ; Middle Aged ; Obstructive Sleep Apnea ; Polysomnography ; Prevalence ; Psychiatric Status Rating Scales ; Quality of Life - psychology ; Republic of Korea - epidemiology ; Risk Factors ; Sleep ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - epidemiology ; Sleep Apnea, Obstructive - psychology ; Surveys and Questionnaires</subject><ispartof>Journal of sexual medicine, 2015-11, Vol.12 (11), p.2168-2177</ispartof><rights>2015 International Society for Sexual Medicine</rights><rights>2015 International Society for Sexual Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4391-acdcaa1ddc4d5ca89b5446b9a13f4b6f03de01adfc2af74e53b753a7a15ba8f93</citedby><cites>FETCH-LOGICAL-c4391-acdcaa1ddc4d5ca89b5446b9a13f4b6f03de01adfc2af74e53b753a7a15ba8f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjsm.13021$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjsm.13021$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26477542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Yung Jin</creatorcontrib><creatorcontrib>Yoon, Dae Wui</creatorcontrib><creatorcontrib>Han, Doo Hee</creatorcontrib><creatorcontrib>Won, Tae-Bin</creatorcontrib><creatorcontrib>Kim, Dong-Young</creatorcontrib><creatorcontrib>Shin, Hyun-Woo</creatorcontrib><title>Low Quality of Life and Depressive Symptoms as an Independent Risk Factor for Erectile Dysfunction in Patients with Obstructive Sleep Apnea</title><title>Journal of sexual medicine</title><addtitle>J Sex Med</addtitle><description>Accumulating evidence indicates that obstructive sleep apnea (OSA) is associated with a high prevalence of erectile dysfunction (ED), but the factors that predict the risk of ED in OSA patients have yet to be defined clearly.
The aims of the present study were to investigate the clinical characteristics of OSA patients with ED and to identify plausible predictors of ED.
The present cross-sectional analysis included 713 male patients who visited Seoul National University Hospital for snoring and/or daytime sleepiness from 2006 to 2014. An in-laboratory polysomnography procedure was conducted to obtain objective recordings of OSA and other sleep parameters.
The demographic data of all patients were obtained, and each patient completed all requirements of the following questionnaires: the Calgary Sleep Apnea Quality of Life Index (SAQLI), the Korean version of the International Index of Erectile Function (KIIEF-5), the Beck Depression Inventory (BDI), and the Epworth Sleepiness Scale (ESS). ED and OSA were defined as a KIIEF-5 < 21 and a respiratory disturbance index (RDI) ≥ 5, respectively. Depressive symptoms were defined as a BDI ≥ 10.
The frequency of ED did not differ significantly according to OSA severity. In Spearman's correlation analysis, the BDI and the ESS were inversely correlated with the KIIEF-5, whereas the SAQLI was positively correlated with the KIIEF-5. The RDI and the lowest oxygen saturation (SaO2) did not exhibit significant correlations with the KIIEF-5. A multivariate logistic regression analysis adjusted for possible confounding factors showed that ED was independently associated with the SAQLI and depressive symptoms, but there was no significant association of ED with either the RDI or the lowest SaO2.
The present study demonstrated that depressive symptoms and a low quality of life specific to sleep apnea are independent risk factors for ED in OSA patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Beck Depression Inventory</subject><subject>Calgary Sleep Apnea Quality of Life Index</subject><subject>Cross-Sectional Studies</subject><subject>Depression - complications</subject><subject>Depression - epidemiology</subject><subject>Epworth Sleepiness Scale</subject><subject>Erectile Dysfunction</subject><subject>Erectile Dysfunction - epidemiology</subject><subject>Erectile Dysfunction - etiology</subject><subject>Erectile Dysfunction - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>International Index of Erectile Function</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obstructive Sleep Apnea</subject><subject>Polysomnography</subject><subject>Prevalence</subject><subject>Psychiatric Status Rating Scales</subject><subject>Quality of Life - psychology</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Factors</subject><subject>Sleep</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Sleep Apnea, Obstructive - psychology</subject><subject>Surveys and Questionnaires</subject><issn>1743-6095</issn><issn>1743-6109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtu1DAUhiMEohdY8ALIS1hMa8dOMllWvUCrQS0U1taJfSxcEju1nY7yDH1pPJ0OK3rky5H8nV_WVxQfGD1iuY7v4nDEOC3Zq2KfNYIvakbb17uettVecRDjHaU8V_m22Ctr0TSVKPeLx5Vfk-8T9DbNxBuysgYJOE3OcAwYo31AcjsPY_JDJJCXI5dO44j5cIn8sPEPuQCVfCAm7_OAKtkeydkczeRy7x2xjtxAspmPZG3Tb3LdxRSm_LgJ7xFHcjI6hHfFGwN9xPfP92Hx6-L85-nXxer6y-XpyWqhBG_ZApRWAExrJXSlYNl2lRB11wLjRnS1oVwjZaCNKsE0AiveNRWHBljVwdK0_LD4tM0dg7-fMCY52Kiw78Ghn6JkTU2XzZJymtHPW1QFH2NAI8dgBwizZFRu3MvsXj65z-zH59ipG1D_I3eyM3C8BdbZ0Pxykry6_baL5NsJzDoeLAYZVfaoUNuNaKm9_c9H_gIZ46Je</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Jeon, Yung Jin</creator><creator>Yoon, Dae Wui</creator><creator>Han, Doo Hee</creator><creator>Won, Tae-Bin</creator><creator>Kim, Dong-Young</creator><creator>Shin, Hyun-Woo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>Low Quality of Life and Depressive Symptoms as an Independent Risk Factor for Erectile Dysfunction in Patients with Obstructive Sleep Apnea</title><author>Jeon, Yung Jin ; Yoon, Dae Wui ; Han, Doo Hee ; Won, Tae-Bin ; Kim, Dong-Young ; Shin, Hyun-Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4391-acdcaa1ddc4d5ca89b5446b9a13f4b6f03de01adfc2af74e53b753a7a15ba8f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Beck Depression Inventory</topic><topic>Calgary Sleep Apnea Quality of Life Index</topic><topic>Cross-Sectional Studies</topic><topic>Depression - complications</topic><topic>Depression - epidemiology</topic><topic>Epworth Sleepiness Scale</topic><topic>Erectile Dysfunction</topic><topic>Erectile Dysfunction - epidemiology</topic><topic>Erectile Dysfunction - etiology</topic><topic>Erectile Dysfunction - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>International Index of Erectile Function</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obstructive Sleep Apnea</topic><topic>Polysomnography</topic><topic>Prevalence</topic><topic>Psychiatric Status Rating Scales</topic><topic>Quality of Life - psychology</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk Factors</topic><topic>Sleep</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>Sleep Apnea, Obstructive - psychology</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeon, Yung Jin</creatorcontrib><creatorcontrib>Yoon, Dae Wui</creatorcontrib><creatorcontrib>Han, Doo Hee</creatorcontrib><creatorcontrib>Won, Tae-Bin</creatorcontrib><creatorcontrib>Kim, Dong-Young</creatorcontrib><creatorcontrib>Shin, Hyun-Woo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of sexual medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeon, Yung Jin</au><au>Yoon, Dae Wui</au><au>Han, Doo Hee</au><au>Won, Tae-Bin</au><au>Kim, Dong-Young</au><au>Shin, Hyun-Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low Quality of Life and Depressive Symptoms as an Independent Risk Factor for Erectile Dysfunction in Patients with Obstructive Sleep Apnea</atitle><jtitle>Journal of sexual medicine</jtitle><addtitle>J Sex Med</addtitle><date>2015-11</date><risdate>2015</risdate><volume>12</volume><issue>11</issue><spage>2168</spage><epage>2177</epage><pages>2168-2177</pages><issn>1743-6095</issn><eissn>1743-6109</eissn><abstract>Accumulating evidence indicates that obstructive sleep apnea (OSA) is associated with a high prevalence of erectile dysfunction (ED), but the factors that predict the risk of ED in OSA patients have yet to be defined clearly.
The aims of the present study were to investigate the clinical characteristics of OSA patients with ED and to identify plausible predictors of ED.
The present cross-sectional analysis included 713 male patients who visited Seoul National University Hospital for snoring and/or daytime sleepiness from 2006 to 2014. An in-laboratory polysomnography procedure was conducted to obtain objective recordings of OSA and other sleep parameters.
The demographic data of all patients were obtained, and each patient completed all requirements of the following questionnaires: the Calgary Sleep Apnea Quality of Life Index (SAQLI), the Korean version of the International Index of Erectile Function (KIIEF-5), the Beck Depression Inventory (BDI), and the Epworth Sleepiness Scale (ESS). ED and OSA were defined as a KIIEF-5 < 21 and a respiratory disturbance index (RDI) ≥ 5, respectively. Depressive symptoms were defined as a BDI ≥ 10.
The frequency of ED did not differ significantly according to OSA severity. In Spearman's correlation analysis, the BDI and the ESS were inversely correlated with the KIIEF-5, whereas the SAQLI was positively correlated with the KIIEF-5. The RDI and the lowest oxygen saturation (SaO2) did not exhibit significant correlations with the KIIEF-5. A multivariate logistic regression analysis adjusted for possible confounding factors showed that ED was independently associated with the SAQLI and depressive symptoms, but there was no significant association of ED with either the RDI or the lowest SaO2.
The present study demonstrated that depressive symptoms and a low quality of life specific to sleep apnea are independent risk factors for ED in OSA patients.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>26477542</pmid><doi>10.1111/jsm.13021</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of sexual medicine, 2015-11, Vol.12 (11), p.2168-2177 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Beck Depression Inventory Calgary Sleep Apnea Quality of Life Index Cross-Sectional Studies Depression - complications Depression - epidemiology Epworth Sleepiness Scale Erectile Dysfunction Erectile Dysfunction - epidemiology Erectile Dysfunction - etiology Erectile Dysfunction - psychology Female Humans International Index of Erectile Function Male Middle Aged Obstructive Sleep Apnea Polysomnography Prevalence Psychiatric Status Rating Scales Quality of Life - psychology Republic of Korea - epidemiology Risk Factors Sleep Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - epidemiology Sleep Apnea, Obstructive - psychology Surveys and Questionnaires |
| title | Low Quality of Life and Depressive Symptoms as an Independent Risk Factor for Erectile Dysfunction in Patients with Obstructive Sleep Apnea |
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