Cellulase Allergy and Challenge Tests with Cellulase Using Immunologic Assessment
Objectives This study attempted to develop and evaluate a challenge test for diagnosing allergic asthma and rhinitis due to cellulase. Methods Challenge tests in a chamber were performed on 11 persons sensitized to cellulase. Four different enzyme-lactose mixtures, starting from a 0.03% mixture, wer...
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| Veröffentlicht in: | Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 2000-06, Vol.26 (3), p.250-256 |
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| container_title | Scandinavian Journal of Work, Environment ＆ Health |
| container_volume | 26 |
| creator | Vanhanen, Markku Tuomi, Timo Tupasela, Outi Keskinen, Helena Tuppurainen, Matti Hytönen, Maija Tarvainen, Kyllikki Kanerva, Lasse Nordman, Henrik |
| description | Objectives This study attempted to develop and evaluate a challenge test for diagnosing allergic asthma and rhinitis due to cellulase. Methods Challenge tests in a chamber were performed on 11 persons sensitized to cellulase. Four different enzyme-lactose mixtures, starting from a 0.03% mixture, were used. The enzyme dust was generated from a dry enzyme preparation mixed with lactose powder, using pressurized air. The cellulase concentration in the air was measured with an immunochemical method. Results Nasal, pharyngeal, or bronchial symptoms could be elicited at cellulase air concentrations of 1 to 1300 µg/m³. A dose-response relationship was observed for symptoms in repeated challenge tests with increasing concentrations of cellulase. For 2 persons skin symptoms could also be reproduced. Conclusion The challenge method proved to be a practical means with which to simulate conditions at the worksite and elicit the specific respiratory symptoms of the patients. |
| doi_str_mv | 10.5271/sjweh.539 |
| format | Article |
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Methods Challenge tests in a chamber were performed on 11 persons sensitized to cellulase. Four different enzyme-lactose mixtures, starting from a 0.03% mixture, were used. The enzyme dust was generated from a dry enzyme preparation mixed with lactose powder, using pressurized air. The cellulase concentration in the air was measured with an immunochemical method. Results Nasal, pharyngeal, or bronchial symptoms could be elicited at cellulase air concentrations of 1 to 1300 µg/m³. A dose-response relationship was observed for symptoms in repeated challenge tests with increasing concentrations of cellulase. For 2 persons skin symptoms could also be reproduced. Conclusion The challenge method proved to be a practical means with which to simulate conditions at the worksite and elicit the specific respiratory symptoms of the patients.</description><identifier>ISSN: 0355-3140</identifier><identifier>EISSN: 1795-990X</identifier><identifier>DOI: 10.5271/sjweh.539</identifier><identifier>PMID: 10901118</identifier><language>eng</language><publisher>Helsinki: Scandinavian Journal of Work, Environment ＆ Health</publisher><subject>Adult ; Allergic bronchopulmonary aspergillosis ; Allergic diseases ; Allergies ; Allergy tests ; Asthma ; Asthma - chemically induced ; Asthma - diagnosis ; Biological and medical sciences ; cellulase ; Cellulase - adverse effects ; Cellulase - analysis ; Cellulase - immunology ; diagnosis ; Dust - adverse effects ; Dyspnea ; Edema ; Enzymes ; Female ; Finland ; Humans ; Immunology ; Immunopathology ; Inhalation Exposure - adverse effects ; Inhalation Exposure - analysis ; Male ; Medical sciences ; Middle Aged ; Occupational Exposure - adverse effects ; Peak expiratory flow rate ; Respiratory and ent allergic diseases ; Respiratory Function Tests ; rhinitis ; Rhinitis - chemically induced ; Rhinitis - diagnosis ; Sensitization</subject><ispartof>Scandinavian Journal of Work, Environment ＆ Health, 2000-06, Vol.26 (3), p.250-256</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a518t-7a48bf15f440dcb692603c5cbcd0c4224799d5400dfb5bbb1ce6c99508b2b5763</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40967056$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40967056$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1404038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10901118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanhanen, Markku</creatorcontrib><creatorcontrib>Tuomi, Timo</creatorcontrib><creatorcontrib>Tupasela, Outi</creatorcontrib><creatorcontrib>Keskinen, Helena</creatorcontrib><creatorcontrib>Tuppurainen, Matti</creatorcontrib><creatorcontrib>Hytönen, Maija</creatorcontrib><creatorcontrib>Tarvainen, Kyllikki</creatorcontrib><creatorcontrib>Kanerva, Lasse</creatorcontrib><creatorcontrib>Nordman, Henrik</creatorcontrib><title>Cellulase Allergy and Challenge Tests with Cellulase Using Immunologic Assessment</title><title>Scandinavian Journal of Work, Environment ＆ Health</title><addtitle>Scand J Work Environ Health</addtitle><description>Objectives This study attempted to develop and evaluate a challenge test for diagnosing allergic asthma and rhinitis due to cellulase. Methods Challenge tests in a chamber were performed on 11 persons sensitized to cellulase. Four different enzyme-lactose mixtures, starting from a 0.03% mixture, were used. The enzyme dust was generated from a dry enzyme preparation mixed with lactose powder, using pressurized air. The cellulase concentration in the air was measured with an immunochemical method. Results Nasal, pharyngeal, or bronchial symptoms could be elicited at cellulase air concentrations of 1 to 1300 µg/m³. A dose-response relationship was observed for symptoms in repeated challenge tests with increasing concentrations of cellulase. For 2 persons skin symptoms could also be reproduced. Conclusion The challenge method proved to be a practical means with which to simulate conditions at the worksite and elicit the specific respiratory symptoms of the patients.</description><subject>Adult</subject><subject>Allergic bronchopulmonary aspergillosis</subject><subject>Allergic diseases</subject><subject>Allergies</subject><subject>Allergy tests</subject><subject>Asthma</subject><subject>Asthma - chemically induced</subject><subject>Asthma - diagnosis</subject><subject>Biological and medical sciences</subject><subject>cellulase</subject><subject>Cellulase - adverse effects</subject><subject>Cellulase - analysis</subject><subject>Cellulase - immunology</subject><subject>diagnosis</subject><subject>Dust - adverse effects</subject><subject>Dyspnea</subject><subject>Edema</subject><subject>Enzymes</subject><subject>Female</subject><subject>Finland</subject><subject>Humans</subject><subject>Immunology</subject><subject>Immunopathology</subject><subject>Inhalation Exposure - adverse effects</subject><subject>Inhalation Exposure - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Exposure - adverse effects</subject><subject>Peak expiratory flow rate</subject><subject>Respiratory and ent allergic diseases</subject><subject>Respiratory Function Tests</subject><subject>rhinitis</subject><subject>Rhinitis - chemically induced</subject><subject>Rhinitis - diagnosis</subject><subject>Sensitization</subject><issn>0355-3140</issn><issn>1795-990X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9r3DAQxUVp6G7SHvoBWnwogR6cjGzJso7L0mQDgRDIQm9CkuVdLf6TamxCvn3leOmW6DIM8-Pp8R4hXylc8UzQazy8uP0Vz-UHsqRC8lRK-P2RLCHnPM0pgwU5RzwAZDLyn8iCggRKabkkj2vXNGOj0SWrpnFh95rorkrWex23bueSJ4cDJi9-2CcndIu-2yV3bTt2fdPvvE1WiA6xdd3wmZzVukH35TgvyPbm19N6k94_3N6tV_ep5rQcUqFZaWrKa8agsqaQWQG55dbYCizLMiakrDgDqGrDjTHUusJKyaE0meGiyC_I5az7HPo_Y3SpWo82WtSd60dUVBRQCiEi-HMGbegRg6vVc_CtDq-KgpryU2_5qZhfZL8fRUfTuuo_cg4sAj-OgEarmzrozno8cQwY5BP2bcYOOPTh35mBLATwyfxmvmsf_ODVoR9DF9NSU2VTYyqD-HgcdPoYpu7eLTxCUeovjFmV8g</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Vanhanen, Markku</creator><creator>Tuomi, Timo</creator><creator>Tupasela, Outi</creator><creator>Keskinen, Helena</creator><creator>Tuppurainen, Matti</creator><creator>Hytönen, Maija</creator><creator>Tarvainen, Kyllikki</creator><creator>Kanerva, Lasse</creator><creator>Nordman, Henrik</creator><general>Scandinavian Journal of Work, Environment ＆ Health</general><general>National Institute for Working Life</general><general>Finnish Institute of Occupational Health</general><general>National Institute of Occupational Health (Denmark)</general><general>National Institute of Occupational Health (Norway)</general><general>Scandinavian journal of work, environment & health</general><scope>188</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20000601</creationdate><title>Cellulase Allergy and Challenge Tests with Cellulase Using Immunologic Assessment</title><author>Vanhanen, Markku ; Tuomi, Timo ; Tupasela, Outi ; Keskinen, Helena ; Tuppurainen, Matti ; Hytönen, Maija ; Tarvainen, Kyllikki ; Kanerva, Lasse ; Nordman, Henrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a518t-7a48bf15f440dcb692603c5cbcd0c4224799d5400dfb5bbb1ce6c99508b2b5763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Allergic bronchopulmonary aspergillosis</topic><topic>Allergic diseases</topic><topic>Allergies</topic><topic>Allergy tests</topic><topic>Asthma</topic><topic>Asthma - chemically induced</topic><topic>Asthma - diagnosis</topic><topic>Biological and medical sciences</topic><topic>cellulase</topic><topic>Cellulase - adverse effects</topic><topic>Cellulase - analysis</topic><topic>Cellulase - immunology</topic><topic>diagnosis</topic><topic>Dust - adverse effects</topic><topic>Dyspnea</topic><topic>Edema</topic><topic>Enzymes</topic><topic>Female</topic><topic>Finland</topic><topic>Humans</topic><topic>Immunology</topic><topic>Immunopathology</topic><topic>Inhalation Exposure - adverse effects</topic><topic>Inhalation Exposure - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupational Exposure - adverse effects</topic><topic>Peak expiratory flow rate</topic><topic>Respiratory and ent allergic diseases</topic><topic>Respiratory Function Tests</topic><topic>rhinitis</topic><topic>Rhinitis - chemically induced</topic><topic>Rhinitis - diagnosis</topic><topic>Sensitization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanhanen, Markku</creatorcontrib><creatorcontrib>Tuomi, Timo</creatorcontrib><creatorcontrib>Tupasela, Outi</creatorcontrib><creatorcontrib>Keskinen, Helena</creatorcontrib><creatorcontrib>Tuppurainen, Matti</creatorcontrib><creatorcontrib>Hytönen, Maija</creatorcontrib><creatorcontrib>Tarvainen, Kyllikki</creatorcontrib><creatorcontrib>Kanerva, Lasse</creatorcontrib><creatorcontrib>Nordman, Henrik</creatorcontrib><collection>Airiti Library</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanhanen, Markku</au><au>Tuomi, Timo</au><au>Tupasela, Outi</au><au>Keskinen, Helena</au><au>Tuppurainen, Matti</au><au>Hytönen, Maija</au><au>Tarvainen, Kyllikki</au><au>Kanerva, Lasse</au><au>Nordman, Henrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellulase Allergy and Challenge Tests with Cellulase Using Immunologic Assessment</atitle><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>26</volume><issue>3</issue><spage>250</spage><epage>256</epage><pages>250-256</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>Objectives This study attempted to develop and evaluate a challenge test for diagnosing allergic asthma and rhinitis due to cellulase. Methods Challenge tests in a chamber were performed on 11 persons sensitized to cellulase. Four different enzyme-lactose mixtures, starting from a 0.03% mixture, were used. The enzyme dust was generated from a dry enzyme preparation mixed with lactose powder, using pressurized air. The cellulase concentration in the air was measured with an immunochemical method. Results Nasal, pharyngeal, or bronchial symptoms could be elicited at cellulase air concentrations of 1 to 1300 µg/m³. A dose-response relationship was observed for symptoms in repeated challenge tests with increasing concentrations of cellulase. For 2 persons skin symptoms could also be reproduced. Conclusion The challenge method proved to be a practical means with which to simulate conditions at the worksite and elicit the specific respiratory symptoms of the patients.</abstract><cop>Helsinki</cop><pub>Scandinavian Journal of Work, Environment ＆ Health</pub><pmid>10901118</pmid><doi>10.5271/sjweh.539</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Allergic bronchopulmonary aspergillosis Allergic diseases Allergies Allergy tests Asthma Asthma - chemically induced Asthma - diagnosis Biological and medical sciences cellulase Cellulase - adverse effects Cellulase - analysis Cellulase - immunology diagnosis Dust - adverse effects Dyspnea Edema Enzymes Female Finland Humans Immunology Immunopathology Inhalation Exposure - adverse effects Inhalation Exposure - analysis Male Medical sciences Middle Aged Occupational Exposure - adverse effects Peak expiratory flow rate Respiratory and ent allergic diseases Respiratory Function Tests rhinitis Rhinitis - chemically induced Rhinitis - diagnosis Sensitization |
| title | Cellulase Allergy and Challenge Tests with Cellulase Using Immunologic Assessment |
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