IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

Interleukin-18 (IL-18) is activated by Caspase-1 in inflammasome complexes and has anti-obesity effects; however, it is not known which inflammasome regulates this process. We found that mice lacking the NLRP1 inflammasome phenocopy mice lacking IL-18, with spontaneous obesity due to intrinsic lipid...

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Veröffentlicht in:	Cell metabolism 2016-01, Vol.23 (1), p.155-164
Hauptverfasser:	Murphy, Andrew J., Kraakman, Michael J., Kammoun, Helene L., Dragoljevic, Dragana, Lee, Man K.S., Lawlor, Kate E., Wentworth, John M., Vasanthakumar, Ajithkumar, Gerlic, Motti, Whitehead, Lachlan W., DiRago, Ladina, Cengia, Louise, Lane, Rachael M., Metcalf, Donald, Vince, James E., Harrison, Leonard C., Kallies, Axel, Kile, Benjamin T., Croker, Ben A., Febbraio, Mark A., Masters, Seth L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Body Weight Diet, High-Fat - adverse effects Inflammasomes - metabolism Interleukin-18 - biosynthesis Interleukin-18 - genetics Liver - metabolism Liver - pathology Male Metabolic Syndrome - metabolism Metabolic Syndrome - prevention & control Mice, Knockout Obesity - etiology Obesity - metabolism Obesity - prevention & control
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